Exam #1 Flashcards
Ectoderm
- outer skin layers, nervous system, sense organs
- inner ear
Mesoderm
- bones of middle ossicles
Endoderm
- digestive canal and respiratory organs
embryology
the branch of biology that deals with the formation, early growth, and development of living organisms
Embryo
Up until the 8th week
Fetus
After the 8th week of development
Three Germ Layers
Endoderm, Ectoderm, Mesoderm
Full term
37 - 40 weeks
- we measure in terms of gestational period, starts from the first day of your last menstral cycle
Neural tube
gives rise to the spinal cord and brain
Neural crest
gives rise to a number of different cell types and neurons
notochord
direts formation of the neural tube - primitive spinal chord
3 Week Gestational Age
- notochord forms
- neural groove (future spinal chord) forms
- brain bulge at end of embryonic disc
- somites form, precursor to genitalia
- primitive heart tube forms
4 Weeks Gestational Age
- heart begins to beat
- branchial arches (form face and neck) form
- Neural tube closes **
- Otic Pit form (precursor to ears)
- arm buds visible
- First sign of lungs, mouth & liver appear
(this is when cleft lip & palate happen)
When is the earliest you can get an ultrasound?
6 weeks - wait until then because you should be able to see a heartbeat by then
What is anacephaly?
- born without a brain
- you can have live birth, but they will die
Spina Bifida
- different lobes of brain, there are different ventricles, you have a build up of cerebrospinal fluid in 4th ventricle
- put in a shunt to solve problem
- both the problem, and the shunt can cause HL
5 Weeks Gestational Age
- Eye begins to develop
- Brain divides into 5 vesicles
- Legs and hands begin to form
- Rudimentary blood begins to move through vessels
7 Weeks Gestational Age
- All essential organs have at least begun to form
- generally know you are pregnant by now
8-10 Weeks Gestational Age
- now FETUS (no longer embryo after 8 weeks)
- face is well formed
- eyelids formed - closed and will re-open around week 28
- genitals appear, but you can’t find out gender until 20 weeks
When do fetus’ eyes open?
28 weeks
When can you find out the gender of your baby?
20 weeks
25 Weeks Gestational Age
- brain develops rapidly
- cochlea developed, fully developed by 20 weeks
- respiratory system developed enough to support gas exchange, makes it feasible for baby to be born here and have a chance at breathing
Toxic Susceptibility Week 0-2:
- Pre organogenesis
- you can’t impact the heart and lungs etc yet because they aren’t there yet, and there is no umbilical chord
- not sensitive to malformation
- significant exposure is lethal
Toxic Susceptibility Weeks 3-8:
- Embryonic Period
- start being susceptible to toxicity issues
- greatest sensitivity to environmental exposures
- fetal mass increases 2.5 million fold first trimester
- major malformations occur (heart, lungs, liver, neural tube)
Toxic Susceptibility Weeks 9-38:
- Fetal Period
- decreasing sensitivity
- functional defects and minor malformations occur
What is the most common addiction for newborns?
- pain medication - moms don’t think it is effecting the baby
Which auricular hillocks come from the first arch?
- Tragus
2. Crus of Helix
What is the only part of the ear that doesn’t form from hillocks?
The ear lobe - “lobule”
Which auricular hillocks come from the second arch?
- Ascending helix
- Upper Helix, Scaphoid & Antihelix
- Descending Helix, Middle Scaphoid, Antihelix
- Antitragus
Three layers of the TM
- Inner layer, endoderm
- middle layer, mesoderm
- outer layer, ectoderm
At what point is the pinna fully developed/adult size?
about 9 years of age
What is the first pharyngeal arch called?
Mackel’s cartilage
What is the second pharyngeal arch called?
Reichert’s cartilage
What forms from the first pharyngeal arch?
- Head of malleus, body and short process of incus
- Tensor tympani muscle
- Trigeminal nerve (V): the mandibular branch supplies tensor tympani muscle
- When you see a problem on the pinna in a spot that has come from the 1st arch - there may something with one of these as well.
What forms from the second pharyngeal arch?
- long process of incus, handle of malleus, stapes superstructure and tympanic surface of footplate
- stapedius muscle
- facial nerve (VII): stapedial nerve
Auditory experience promotes…
myelination of afferent fibers
When is frequency discrimination mature?
Frequency discrimination is adult like by 6 months postnatally, but thresholds mature through childhood
How many babies are born with hearing loss
3/1000
- NICU causes bigger issues, approx 2.5/100
idiopathic
- no idea what happened
Environmental
- drug exposure during birth, the chord wrapped around the neck, we know what happed to cause issues
Alport
- progressive SNHL
- renal disease (kidney) eye anomalies, mild to severe (bilateral) physical deformities, chance that loss will progress with age
- more males than females
NF2
- progressive SNHL
- neurofibromatosis 2 slowly progressive loss, tumors on auditory nerve (acoustic neuroma or vestibular schwanoma) when you remove them, hearing is last with no chance to help, tumors come back