Exam 1 Flashcards
Simple Squamous Function
Diffusion, filtration, secretion
Simple Cuboidal Function
Secretion, Absorption
Simple Columnar Function
Absorption, secretion, propulsion of mucus and enzymes
Pseudostratified Columnar Function
Secretion and propulsion of mucus
Stratified Squamous
Protection
Stratified Cuboidal Function
Protection
Stratified Columnar Function
Protection and secretion
Transitional Function
Permits distension or urinary organs when filled with urine (by flattening)
String tying epithelial cells together
Tight Junctions
Plaque and Intermediate filaments for binding and structure
Desmosomes
Passageway between two adjacent cells that allow molecules to pass through
Gap Junctions
Maximize surface area
Microvilli
Hairlike extensions that generate movement
Cilia
Areolar
All three fibers, fibroblasts, mast cells, WBCs
Wrap and cushion organs, hold and convey tissue fluid, inflammation (bc of WBCs)
Adipose Tissue
Adipocytes, fat droplet
Provide reserve food fuel, insulate against heat loss, support and protect organs
Reticular CT
Lots of reticular fibers, fibroblast, WBCs
Form soft, internal skeleton (stroma), support other cell types
Dense Regular Connective Tissue
Fibroblasts, lots of collagen fibers, tensile strength, poorly vascularized, forms fascia
Tendon, ligament, withstand stress
Dense Irregular CT
Collagen fibers irregularly arranged, elastic fibers and fibroblasts
Withstand tension in multiple directions, structural strength
Elastic CT
Elastic fibers, fibroblasts
Allows recoil after stretching
Hyaline Cartilage
Chondroblasts, chondrocytes in lacuna
Supports and reinforces, acts as cushion that resists repetitive stress
Elastic Cartilage
Chondrocytes in lacuna, more elastic fibers
Maintain shape and structure, flexibility
Fibrocartilage
Thick collagen fibers, chondrocytes in lacuna
Tensile strength and ability to absorb compressive shock
Bone Tissue
Calcium, collagen, osteoblasts, osteocytes in lacuna
Support and protect, provide levers and attachment sites for muscles, store calcium and minerals, store fat, blood cell formation
Blood Tissue
Red and white blood cells in extracellular matrix (blood plasma)
Transport respiratory gases, nutrients, wastes
Rheumatoid Arthritis
Joints that are used a lot are attacked by the immune system. Become inflamed and cause pain and stiffness.
Lupus
Autoimmune, tissue damage, affects heart, lungs, kidney, brain, flare-ups and remission
Marfan Syndrome
Inherited disorder, patients tend to to be tall and thin, present with extremely flexible joints and curved spines, if cardiovascular tissue is affected will cause heart murmurs or aortic aneurysms
Fibrodysplasia ossificans progressive
Turns muscle and connective tissue to bone, autosomal dominant disorder, children have malformed big toes, immobility
Integral Proteins
Border control
Peripheral Proteins
Understand what’s happening in the extracellular environment
Phagocytosis
Cell eating
Pinocytosis
Cell drinking
Receptor-mediated endocytosis
Plasma proteins bind to molecules, that part of the membrane pinches inside the cell to become a vesicle
Rough ER
Make proteins and digestive enzymes
Smooth ER
No ribosomes, lipid metabolism, store calcium ions “sarcoplasmic reticulum”
Golgi apparatus
Sorts products of ER and sends where they need to go
Peroxisomes
Sac of enzymes to neutralize free radicals (toxins), liver and kidneys
Proteasomes
Barrel-shaped that destroy unneeded, damaged, or faulty proteins into smaller peptides
Centrosomes
Spherical structure composed of centrosome matrix and centrioles
Centrioles
Paired cylindrical bodies consisting of short microtubules, form cilia, flagella, mitotic spindle
Nucleolus
Site of ribosome subunit assembly
Interphase
G1 phase, S phase, G2 Phase
G1 Phase
Metabolically active, make proteins, growth, centrioles begin to replicate
S phase
DNA makes 2 identical copies
G2 Phase
Centrioles finish copying, enzymes needed for cell division are synthesized
G checkpoints
Stops from replication if unfit, prevent cancer
Mitosis
Prophase, metaphase, anaphase, telophase
Prophase
Loose DNA (chromatin) condenses into chromosomes, centriole pairs separate from each other to opposite poles, mitotic spindle forms, nuclear membrane fragments
Metaphase
Chromosomes aligned along equator
Anaphase
Centromeres of chromosomes split by mitotic spindles
Telophase
Chromosomes uncoil, new nuclear envelope forms
Cytokinesis
Split one cell into two
Composition of blood
Plasma 55
Erythrocytes 45
Buffy coat (leukocytes and platelets) less than 1
Blood Plasma Components
Ions, nutrients, wastes, proteins: Albumin (prevent water from diffusing due to osmosis), Globulins (includes antibodies and blood proteins that transport lipids, iron, copper), Fibrinogen (precursor for fibrin)
Function of iron on hemoglobin
Binds to 4 oxygen molecules
Function of nitric acid in hemoglobin
Causes vasodilation to improve blood flow
Function of carbonic anhydrase
Converts carbon dioxide and water to carbonic acid to transfer CO2 in plasma
Function of erythropoietin
Released by kidneys in response to hypoxia to stimulate hematopoiesis
Neutrophils
Granulocyte, two to six lobe nucleus, first line of defense against bacteria signaled by bacterial products, phagocytize and destroy bacteria
Eosinophils
Granulocytes, bilobed, stain red, active during allergic reactions and parasitic infections, end allergic reactions by phagocytize allergens and degrade histamines (cause inflammation) with enzymes
Basophil
Granulocyte, secretes histamines to cause inflammation
Lymphocytes
Agranulocyte, specialized immune cells, T cells attack antigens, B cells produce antibodies to signal macrophages
Monocytes
Transform into macrophages to phagocytose cells
Bone Marrow as the Site of Hematopoiesis
Fibroblasts are reticular cells c blood sinusoids run through reticular tissue, allow mature blood cells to enter blood stream
Polycythemia
Too many RBCs, too dense and thick
Anemia
Low RBCs/hemoglobin
Sickle Cell Disease
Genetic, RBCs are sickle shape due to hemoglobin defect
Leukemia
Form of blood cancer
Thrombocytopenia
Low platelets
3 stages of hemostasis
Vasoconstriction, platelet plug, produce fibrin to form a clot
Role of PGl2 and nitric oxide
Vasodilation, reduce platelet aggression
von Willebrand factor
Protein as a bond between collagen and platelets
Role of ADP and thronboxane A2 in Hemostasis
Released by platelets in plug to signal other platelets to come
Role of fibrin in hemostasis
Activation of platelets turns fibrinogen into fibrin, densely packs the plug
Layers of Heart
Fibrous Pericardium, Parietal Serous Pericardium, Visceral Serous Pericardium/Epicardium, Myocardium (muscle), Endocardium (endothelium)
Blood Vessel Structure
Tunica interna, tunica media (muscle, elastic fibers), tunica externa
Veins differences from Arteries
Less tunica interna and tunica media, thicker tunica externa (less elastic and muscle tissue)
Capillary Exchange - Diffusion
Product of concentrations
Capillary Exchange - Transcytosis
Exocytosis and endocytosis
Capillary Exchange - Bulk Flow
Product of high pressure to low pressure
Filtration
Increased blood hydrostatic pressure drives blood out of capillaries due to high pressure from the arteries
Reabsorption
Blood colloid osmotic pressure brings blood into capillaries due to high concentration of proteins