Exam 1 Flashcards
Inflammation is triggered by?
Histamine
What are the 5 cardinal signs of inflammation
- Heat
- Pain
3.Redness - Swelling
5.Loss of Function
Is an injury to a ligament
Sprain
Is an injury to a muscle or tendon
Strain
What happens immediately after injury that causes platelet plug formation to help stop bleeding
Hemostasis
What does PRICE stand for?
Protection, Rest, Ice, Compression, Eleveation
What stage is associated with
1. Inflammation,
- some fibroblast which produce type III collagen
- Last 4-7 Days
Acute
What stage is associated with
- Tissue begins to regenerate
- Fibroblast produce significant amount of Collagen
- Collagen creating granulation tissue
- 2-4 weeks in duration ( from when Inflammation decreases)
Subacute
What Stage is associated with
- Tissues Remodels
- Maturation
3 Collagen is most easily manipulated in the first 10 weeks.
- When Subacute phase ends up to 12-18 months .
Chronic
Hemostasis and degenration of week fragile tissue is associated with which phase of ligament healing, and what is the timeline.
Hemostasis or Phase 1
Immediate
Vasodilation and scar formation; break down and remove dead cells; unstable type 3 collagen are characteristic of which stage of ligament healing and what is the timeline?
Inflammation Stage
Days 3-14
angiogenesis; very gradual changes in type 3 collagen strength; tissue changes from cellular to fibrous, is associated with what stage of ligament healing and what is the timeline.
Proliferation
Day 14-60
Associated with production of type 1 collagen aligning with the scar. What is it’s timeline?
Remodeling and Maturation
Day 60-120
What stage of Muscle and Tendon healing is associated with the list below and please provide the timeline.
- Rupture of blood an lymphatic vessels with initial vasoconstriction. Coagulation.
- Clot formation
- Vasodilation
- Phagocytosis
- Chemical mediators control inflammatory process
Acute Stage
Immediate-6 days
What stage of Muscle and Tendon healing associated with the list below and please provide the timeline.
- Decrease inflammation
- Decrease in clot size
- Increase in granulation tissue(fibroblast, myofibroblast, and capillaries
- Repair process initiated
- Angiogenesis( new blood supply to the area)
Subacute
Day 3-3 weeks
What stage of Muscle and Tendon healing associated with the list below and please provide the timeline.
- Remodling of scar
- Collagen Thickens and strengthens
Chronic Stage
3 weeks to years after
What stage of bone healing are the following characteristics associated with and please provide the timeline.
- Hematoma formation at the fracture site.
- Inflammation with cytokine release.
- Formation of a fibrin clot.
Stage 1 (Bleeding and Hematoma)
0 days to 1 week
What stage of bone healing are the following characteristics associated with and please provide the timeline.
- Fibroblasts and chondrocytes proliferate at the fracture site.
- Formation of a soft callus made of collagen and cartilage.
- Capillary ingrowth begins.
Stage 2 or (Granulation)
What stage of bone healing are the following characteristics associated with and please provide the timeline.
- Soft callus is replaced by a hard, bony callus made of woven bone.
- Bone remodeling begins with osteoblast activity.
Stage 3 (Osteoblast)
3 weeks to 6 Months
What stage of bone healing are the following characteristics associated with and please provide the timeline.
- Woven bone is replaced by lamellar bone.
- Bone continues to remodel with osteoclast
- Fracture site returns to normal bone structure.
Stage 4 ( Osteoclast Reabsorption)
6 months- 1 year
What type of cartilage is associated with these characteristics?
-Found in Joint surfaces (ex knee, hip
- Smooth cartilage.
- Made up of type II collagen, chondrocytes, and extracellular matrix.
-Avascular -Nutrients come from synovial fluid.
- Provides a smooth, low-friction surface for joint movement.
- Distributes joint load and pressure.
- Minimal regeneration or repair after injury due to lack of vascular supply.
- Healing mainly through chondrocyte migration from the surrounding cartilage or synovial fluid
Articular or (hyaline)
What type of cartilage is associated with these characteristics?
-Found in the Menisci and the labrum
- Dense collagen fibers,
-primarily type I collagen
- Has a fibrous structure, making it more durable with less elasticity
- Partial vascular supply
-only the outer region of the meniscus and labrum have a blood supply.
- The inner part will be avascular
- Acts as a shock absorber and stabilizer in joints
- Supports load distribution, in weight-bearing joints.
-Better healing potential compared to articular cartilage
The outer regions with vascular supply can heal with cell migration and blood flow.
- The inner, avascular areas heal poorly, often requiring surgical intervention
Fibrocartilage
What is the most common type of hip fracture?
Intertrochamteric
This type of hip fracture occurs in the femoral neck, which is the bridge between the femoral head and the shaft of the femur
Intracapsular fractures