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LASC 365 > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

Using a cell culture in an oncology study.

A

replacement

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2
Q

Give nonsteroidal anti-inflammatory drug in food for pain relief

A

Refinement

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3
Q

Use of mice rather than dogs in a study

A

replacement

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4
Q

Use multiple areas on back of pigs for a skin study.

A

reduction

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5
Q

House social animals in groups rather than individually

A

refinement

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6
Q

Which of the following incidents led to the passing of The Laboratory Animal Welfare Act?

A) Animal Liberation Front break-in at the University of Pennsylvania
B) Drs. Magendie and Claude Animal Experimentation
C) Michael Vick Dog Fighting Case
D) The “Pepper” Incident, dog stolen from owner’s backyard and sold to a research
facility

A

The “Pepper” Incident, dog stolen from owner’s backyard and sold to a research
facility

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7
Q

Which of the following was the first animal welfare regulation passed in the United States?

a.) The Laboratory Animal Welfare Act
b. Twenty-Eight Hour Law - Britain
c. Cruelty to Animals Act -UK
d. The Animal Welfare Act
e. None of the above

A

b. Twenty-Eight Hour Law - Britain

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8
Q

Which example condition would require an institution to comply with the Public Health Service Policy on the Humane Care and Use of Laboratory Animals?

a. AAALAC Accreditation
b. Research program supported by the National Institutes of Health
c. Registration as a research facility with the USDA
d. Citation under the Animal Welfare Act

A

Research program supported by the National Institutes of Health

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9
Q

Requires Institutions to submit an assurance that the institution will conduct all animal research in accordance with The Guide and other federal regulations.

A) Public Health Service Policy
B) Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)
C) Animal Welfare Regulations
D) Food and Drug Administration
E) United States Department of Agriculture

A

Public Health Service Policy

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10
Q

Provides peer evaluation of animal care and use programs

A) Public Health Service Policy
B) Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)
C) Animal Welfare Regulations
D) Food and Drug Administration
E) United States Department of Agriculture

A

Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)

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11
Q

Describes what a facility must do to comply with the Animal Welfare Act

A) Public Health Service Policy
B) Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)
C) Animal Welfare Regulations
D) Food and Drug Administration
E) United States Department of Agriculture

A

Animal Welfare Regulations

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12
Q

Requires compliance with the Good Laboratory Practices

A) Public Health Service Policy
B) Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)
C) Animal Welfare Regulations
D) Food and Drug Administration
E) United States Department of Agriculture

A

Food and Drug Administration

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13
Q

Registers institutions using species covered by the Animal Welfare Act

A) Public Health Service Policy
B) Association for Assessment of Accreditation of Laboratory Animal Care, International, (AAALAC)
C) Animal Welfare Regulations
D) Food and Drug Administration
E) United States Department of Agriculture

A

United States Department of Agriculture

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14
Q

Gave the official name of
the Animal Welfare Act
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

1970

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15
Q

Appointed IACUC
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

1985

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16
Q

Made animal fighting, or the selling of animal fight equipment a felony offense
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

2007

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17
Q

Changed the definition of
“animal” to exclude rats, and mice bred for use in research
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

2002

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18
Q

Pounds must hold pets for
5 days prior to adoption or euthanasia
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

1990

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19
Q

Must consult with a DVM
(veterinarian) when planning painful procedures
? Year

A) 1970
B) 1985
C) 1990
D) 2002
E) 2007

A

1985

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20
Q

What must an institution housing USDA-covered species do annually as required by the Animal Welfare Regulations?

a. Submit an annual report of animals used and categorized by their pain category
b. Obtain/renew their research license
c. Report the average daily animal census
d. Submit health records of all housed animal

A

Submit an annual report of animals used and categorized by their pain category

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21
Q

AAALAC primarily uses this document for accrediting an institutions Laboratory Animal Facilities.

a. PHS policy
b. Animal Welfare Act
C. The Guide for the Care and Use of Laboratory Animals
d. Good Laboratory Practices

A

The Guide for the Care and Use of Laboratory Animals d. Good Laboratory Practices

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22
Q

Mus musculus

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Public Health Service Policy Only

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23
Q

Canis familiaris used in cancer research

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Both

24
Q

Rat bred for research

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Public Health Service Policy Only

25
Q

Guinea Pigs

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Both

26
Q

Wild mouse used in research

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Both

27
Q

Sheep used in wool study

A. Animal Welfare Act Only
B. Public Health Service Policy Only
C. Both
D. Neither

A

Neither

28
Q

What does IACUC stand for, what is their purpose, and how often do they inspect laboratory animal facilities?

A

– Institution of Animal Care and Use Committee
– review and investigate the care and use of research animals
– every 6 months

29
Q

TRUE or FALSE

The IACUC committee is required to review and investigate the care and use of research animals raised by members of the public or by animal care or research personnel.

A

TRUE

30
Q

Name 3 of the 5 positions that are required to be apart of the IACUC committee, either from the PHS Policy.

A

1 vet, 1 unaffiliated person, 1 member of IACUC

31
Q

This organization first published the Guide for the Care and Use of Laboratory Animals

a. USDA
b. AWA
c. AALAS
d. ILAR
e. NSBR

A

ILAR

32
Q

This organization allows for lab animal specialty training for veterinarians and technicians. (abbreviations are not accepted)

A

American Association for Laboratory Animal Science

33
Q

This is a veterinary medical specialty that is recognized by the Animal Veterinary Medical Association. Veterinarians that are trained in Lab Animal Medicine are board certified into this organization.

a. AALAS
b. OLAW
c. AAALAC
d. ACLAM

A

ACLAM

34
Q

Which of the following is false regarding purpose bred and random bred dogs used in research? (select all that apply)

a. Random bred animals are purchased by Class A dealers and resold to research laboratories
b. Purpose bred animals typically have similar genetic backgrounds and known pedigrees
c. Random bred animals are desirable due to their genetic and size diversity
d. Purpose bred animals typically have more health problems
e. Purpose bred animals are normally accustomed to cage life
f. Random bred animals are normally more expensive to purchase

A

A. Random bred animals are purchased by Class A dealers and resold to research laboratories
D. Purpose bred animals typically have more health problems
F. Random bred animals are normally more expensive to purchase

35
Q

TRUE or FALSE

In 2009 the NIH ruled that Class B Animal Dealers were necessary to perform animal research. This was due to the desirability for genetic diversity

A

FALSE

36
Q

Programs using chimps will only be federally funded if

a. Knowledge gained must be necessary to advance the public’s health
b. No other research model can be used and gain the same information, or the research cannot be ethically performed on human subjects.
c. The animals used must be maintained either in ethologically appropriate physical and social environments or in natural habitats.
d. All of the above must be met

A

d. All of the above must be met

37
Q

Name one characteristic of the order Rodentia

A

One pair of upper incisors

38
Q

Identify one characteristic of the order Lagomorpha.

A

6 Incisors

39
Q

Mouse Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Musculus

40
Q

Rat Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: rattus

41
Q

Gerbil Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Cricetidae
Genus: Merionnes
Species: Unguiculatus

42
Q

Hamster Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Cricetidae
Genus: Mesocricetus
Species: Auratus

43
Q

Guinea Pig Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Caviidae
Genus: Cavia
Species: Porcellus

44
Q

Rabbit Taxonomy

Kingdom
Phylum
Class
Order
Family
Genus
Species

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Lagomorpha
Family: Leporidae
Genus: Oryctolagus
Species: Cuniculus

45
Q

Which of the following is false regarding inbred strains?

a. They share a common genetic background
b. Strategically bred to maintain genetic heterozygosity
c. Useful for understanding specific effects related to an experimental manipulation
d. Balb/c is a type of inbred strain
e. None of the above all are true

A

Strategically bred to maintain genetic heterozygosity

46
Q

Which of the following is true about mutations/genetic alterations?

a. Can occur spontaneously or by chemical/physical environmental factors
b. Are always desired when they occur
c. Mutations or genetic alterations will always be seen as an observable change in behavior or appearance
d. None of the above all are true

A

Can occur spontaneously or by chemical/physical environmental factors

47
Q

Which of the following is true regarding the mouse strain B6C3F1/Crl?

a. This strain is a transgenic strain B6C3 is the inserted transgene
b. This is an outbred stock that was bred to produce a transgenic
c. This strain is an F1 hybrid which consists of breeding two established inbred
strains
d. This is an inbred strain that was created at Jackson Laboratories

A

This strain is an F1 hybrid which consists of breeding two established inbred strains

48
Q

Gene Targeting can produce pups with tissues from both modified stem cells and normal host stem cells. They most commonly have an easily identified coat color and pattern. They are termed:

A

Chimeras

49
Q

? is the process of introducing an exogenous gene into a living organism. The organism will exhibit a new property and transmit that property to its offspring.

a. Gnotobiologics
b.) Transgenics
c. Hybridogenesis
d. Pronucleogenesis

A

Transgenics

50
Q

Which of the following is a more “accurate” process when inserting a gene into a
genome?

a. Gene Targeting
b. Pronuclear Injection

A

Gene Targeting

51
Q

Which of the following are considered gnotobiotic? (select all the apply)

a. Conventional
b. Axenic
c. Humanized flora
d. Specific pathogen free
e. Defined flora
f. Limited flora

A

Axenic and Defined flora

52
Q

TRUE or FALSE

Transgenic animals can have altered growth, compromised immune systems and increased reproductive efficiency.

A

FALSE

53
Q

List three things that a Trexler isolator must provide:

A

– Temperature control
– Light/dark
– Sterile water storage

54
Q

TRUE or FALSE

All germ-free animals are transgenic.

A

FALSE

55
Q

You are in charge of a large germ-free colony. During your periodic microbiologic sampling you notice that there are 3 bacteria noted on a direct smear. Which of the following is true?

a. The bacteria are due to contamination that occurred outside of the isolator
b. The isolator may be compromised, meaning these animals may no longer be germ-free
c. The contamination of the isolator can be corrected, just spray the entire inside of
the isolator with disinfectant, including the animals
d. Everything is fine, continue with the experiment and the isolator as previously
planned

A

The isolator may be compromised, meaning these animals may no longer be germ free

56
Q

What is the most common method of sterilization?

a. Gamma irradiation
b. Steam Autoclave
c. Dry Heat
d. Membrane filtration

A

Steam Autoclave

57
Q

TRUE or FALSE

To create a germ-free animal from a conventional colony, the pups must pass through the birth canal before being placed into the isolator.

A

FALSE

LASC 365 (4 decks)

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