Exam 1

Question 1

What happened in 430 BCE wit thucydides?

Answer 1

eyewitness account of plaque to promote survival upon future disease occurences

Question 2

What happened in the 10th century with rhazes?

Answer 2

use of humor theory to distinguish different contagious diseases

Question 3

What happened in 1000 Ad in china?

Answer 3

immunization practiced using crusts of small pox leasions

Question 4

What happened in 1546 with Girolamo Francastoro?

Answer 4

proposed that epidemics are caused by transferal of seed-like entities

Question 5

What happened in 11th Century avicenna?

Answer 5

refinement of the theory of acquired immunity

Question 6

What happend in 1720 great britain?

Answer 6

inoculation using small pox to prevent smallpox infection

Question 7

What happened in 1796 with Edward Jenner?

Answer 7

inoculation with cowpox to prevent smallpox infection

Question 8

What happened in 1862 with ernst haeckel?

Answer 8

recognition of mast cell

Question 9

What happened in 1880 with louis pasteur and emile roux?

Answer 9

vaccination of chickens against cholera using an attenuated culture of vibrio cholerae

Question 10

What happened in 1884 with Ilya Machnikov?

Answer 10

cellular theory of immunity

Question 11

What happened in 1890 with Emil von Behring and Shibassaburo Kitasato?

Answer 11

theory of humoral immunity

Question 12

What happened in 1891 with robert koch?

Answer 12

discovery of delayed- type hypersensitivity

Question 13

What happened in 1894 with jules bordet?

Answer 13

discovery of the complement system

Question 14

What happened in 1897 with paul ehrlich?

Answer 14

theory of antibody formation

Question 15

What happned in 1901 with Karl Landsteiner?

Answer 15

discovery of A, b, O blood groups

Question 16

What happened in 1906 with Clemens von Pirquet

Answer 16

term allergy coined

Question 17

What happened in 1932 with alexander gienny?

Answer 17

discovery of adjuvants

Question 18

What happened in 1944 with Peter Medawar and Thomas Gibsom?

Answer 18

discovery of the immunological basis of transplantation immunology

Question 19

What happened in 1948 with astrid fagraeus?

Answer 19

discovery of antibody production occurring in B cells

Question 20

What happened in 1958 with frank McFarlane burnet?

Answer 20

development of the clonal selection theory

Question 21

What happened in 1959-1962 with Gerald Edelman and Rodney Porter?

Answer 21

determination of the structure of antibodies

Question 22

What happened in 1961-1962 with Jacques Miller?

Answer 22

discovery of the thymus involvement in cellular immunity

Question 23

What happened in 1974 with Rolf Zinkernagel and Peter Doherty

Answer 23

demonstration of MHC restriction of T cells in their antigen response

Question 24

What happened in 1976 with Susumu Tonegawa

Answer 24

ID of somatic recombination of immunoglobulin genes

Question 25

What happned in 1983?

Answer 25

discovery of the T-cell antigen receptor

Question 26

What happened in 1990 with david baltimore?

Answer 26

discovery of the role of RAG genes in VJ recomination

Question 27

What happned in 1994 with Polly Matzinger?

Answer 27

development of the danger model of immunological tolerance, whereby self reactive lymphocytes are deleted from the population