Exam 1 Flashcards
The CNS is made up of the ___
brain and spinal cord
The CNS ____
controls and mediates behavior
The PNS is made up of the ____
somatic, autonomic, and enteric systems
The somatic system ___
controls the cranial and spinal nerves
The autonamic system ___
controls organs and glands, parasympathetic and sympathetic
The enteric system ___
controls the gut
Ramon y Cajal discovered that
neurons don’t actually touch
Synapses are mostly formed as ___
babies and toddlers
Nissyl Staining reveals
cell bodies
Golgi staining reveals
cell bodies + dendrites
Electron Microscope reveals
individual neurons
Multi-photon microscope reveals
detailed images
Glial cells are the ___ of the brain
glue
Ependymal Cell
makes the spinal fluid
Astrocyte
blood brain barrier so toxic substances don’t enter
Micro glial cells
clear waste from the brain
Oligiodendrocytes
make up mylein sheath in CNS
Schwannn cells
make up myelin sheath in PNS
Neurons talk to each other via ___
electrochemical transmission
what are oscilloscopes used to study
electrochemical signals and resting potential
what happens in the depolarization phase
Na+ rushes in and K+ channels open and K+ leaves but slowly
what happens in the repolarization phase
K+ continues to leave to restore membrane potential
When is there an absolute refractory phase
depolarization and repolarization
when is there a relative refractory phase
hyperpolarization
Step 1 of Lifecycle of Neurotransmitter
Synthesized from precursor
Step 2 of Lifecycle of Neurotransmitter
Transported to axon terminal if needed
Step 3 of Lifecycle of Neurotransmitter
Packaged into vesicles
Step 4 of Lifecycle of Neurotransmitter
released via exocytosis after action potential
pros of gap functions (electrical synapse)
fast, bidirectional, does not require a lot of energy
con of gap functions (electrical synapse)
no mechanism for plasticity
pro of chemical synapses
plasticity
con of chemical synapses
slow, requires energy and neurotransmitters
Synapses are the site for ___
neural basis of learning
are inotropic or metabotropic receptors quicker
inotrpic
2 types of Hebbian Learning
habituation and sensitization
Hebbian Learning
connections between a pre and post synaptic neuron will be strengthened following coordinated activity and weakened during uncoordinated activity
Sensitization definition
neurons become more responsive to stimuli with repeated stimulation
How does sensitization work?
repeated stimulus because cAMP causes K+ channels to be less active which causes a longer action potential so more Ca2+ enters the cell during the long depolarization phase so more vesicles of neurotransmitters are released into the synapse which results in larger EPSPs
Habituation definition
neurons become less responsive to stimuli with repeated stimulation
How does habituation work?
repeated stimulus means less Ca2+ is around so less Ca2+ enters the cell, so less neurotransmitters are released into the synapse which results in smaller EPSPs
non associative learning
learning that does not require stimuli association or pairing
3 categories of neurotransmitters
Large Neuropeptides, small molecules, and lipids
Example of a large neuropeptide
opiods
example of lipids
endocannabinoids
3 categories of small molecules
Amino acids, amines, acetylcholine
2 amino acids
glutamate and GABA
2 categories of amines
catecholamines and Seratonin
3 catecholamines
dopamine, epinephrine, and norepinephrine
Glutamate Features
excitatory and involved in learning and memory
Death Mechanism of Glutamate
Glial Uptake
Too much Glutamate causes
excitotoxicity which leads to loss of neural function and cell death
Features of GABA
inhibitory and receptors are ligand gated Cl- channels
Death Mechanism of GABA
Glial Uptake
Epilepsy drugs target ___
GABA
Acetylcholine (ACh) features
made from food, converted with enzymes, and especially present for when neurons meet muscles
Death Mechansim of ACh
enzymatic breakdown
What happens if ACh is inhibited
muscles continuously contract until you die
Dopamine (DA) features
excitatory and inhibitory, involved in everything
Death Mechanism of DA
reuptake + enzymatic breakdown
Norepinephrine (NE) features
invovled in sleep, arousal, alertness
Death Mechanism of NE
reuptake + enzymatic breakdown
Epinephrine (EP) features
fight or flight
Death Mechanism of EP
reuptake + enzymatic breakdown
Seratonin (5HT) features
mood, aggression, respiration, appetite
Death Mechanism of 5HT
reuptake + enzymatic breakdown
Order that the Catecholamines were formed
Dopamine –> norepinephrine –> epinephrine
gray matter
anything not myelinated
white matter
mylenated axons
Neocortex
newest part with 6 layers
Allocortex
the older and more inner part of the brain with only 3-4 layers
What lobe is the precentral gyrus in
Frontal
What lobe is the postcentral gyrus in
parietal
4 functions of Frontal lobe
executive functioning, decision making, planned motor movements, integration
3 functions of Parietal Lobe
somatosensory information, attention, spatial information
Occipital lobe function
Vision
3 Functions of Temporal Lobe
hearing, language, and memory
Function of Insula
emotion (integration of emotion and cognition)
What 2 lobes does the central sulcus separate?
Frontal and Parietal
What 2 lobes does the lateral sulcus/sylvian fissure separate?
Frontal and Temporal
What does the interhemispheric/longitudinal fissure separate
both hemispheres
3 parts of the Forebrain: Telencephalon
Cerebral Cortex, Basal Ganglia, Limbic System
Cerebral Cortex Function
brains outermost layer of nerve tissue
Basal Ganglia Function
voluntary movements and reward/punishment
Limbic System Function
Motivated/goal orientated behaviors and memory
Hippocampus Function
memory
2 parts of Forebrain: Dienchephalon
Thalamus and Hypothalamus
Thalamus Function
collection of nuclei, relay station for senses
Hypothalamus Function
homeostasis, links CNS with endocrine system
Majority of dopamine is created in the __
midbrain
3 parts of Hindbrain
Cerebellum, pons, and medulla
The Hindbrain main function
survival
Cerebellum Function
Coordinating movements, balance and more
Pons Function
respiration and swallowing
Medulla Function
respiration, heart rate, vommitting toxic substances, conciousness
5 parts of the Brain Stem
Pons, medulla, midbrain, thalamus, and hypothalamus
Dura Matter
durable
Arachnoid Matter
Spongy layer
Pia Matter
thin and follows folds and grooves
Cerebrospinal fluid (CSF) function
surrounds brain and spinal cord, fills lateral ventricles to act as a protective layer
Arteries Function
carry oxygenated blood and glucose away from heart to brain
Veins Function
carry deoxygenated blood and lactic acid away from brain to heart
Circle of Willis Function
blood supply of brain and protects against parts failing
What are cytoarchitectonic maps
maps that show the brodman areas where each region has a different type of cell
Infants form synapses at a rate of
200,000 per second
we ___ neurons as we get older
lose
Potential
ability to use stored power
Which ions are primarily in the cell
Anions and Potassium
Which ions are primarily outside of the cell
Sodium and Chloride
How many neurons are there
100 billion
A neuron recieves 8 inputs. 4 are excitatoty and 4 are inhibatory. The EPSPs are close together and the IPSPs are far apart. The EPSPs enter at dif times and IPSPs enter at the same time. What happens?
they cancel out, leading to no AP
When the Action Potential reaches the axon terminal, the change in membrane voltage causes ___
Ca2+ channels to open
What are autoreceptors
receptors on the presynaptic membrane regulate amount of neurotransmitter released – typically cause less neurotransmitters to be released
4 ways for neurotransmitters to die
diffusion, enzymatic breakdown, reuptake, glial uptake
What does the Hodgkin and Huxley Model represent?
the dynamic characteristics of the neuron by mimicking the action potential, ionic channels, and spiking behaviors.
3 types of changes in syntatic learning
changing to be less common, changing to be more common, changing quantities
where does Ca2+ send instructions to make more synapses, more dendritic spines, or larger synpases
nuclear DNA
acetyl coA + choline –> ChAT –> ?
ACh
what does AChE do
kills ACh
Tyrosine – > L-Dopa –> ? –> ? –?
Dopamine, Norepinephrine, Epinephrine
what neurotransmitters do MAO and COMT break down
DA, NE, EP, 5HT
which Neurotransmitter is really important for learning and memory
Glutamate
neurons can release __ neurotransmitters
2+
the corpus callosum is made up of ___
200 million heavily myelinated axons
what does the basal ganglia consist of
subcortial nuclei that looks like eagle wings on an axial slice