Exam 1 Flashcards

1
Q

Primary receptor of parasympathetic

A

Cholinergic

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2
Q

Primary neurotransmitter of parasympathetic

A

Acetylcholine

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3
Q

Primary receptor of sympathetic

A

Adrenergic

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4
Q

Primary neurotransmitter of sympathetic

A

Norepinephrine

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5
Q

Direct acting cholinergic agonist

A

Bethanechol; activates cholinergic receptors causing bladder muscle relaxation

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6
Q

Bethanechol SE/AE

A

tachycardia and hypotension

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7
Q

Prototype anticholinergic

A

Atropine; blocks cholinerguc effects

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8
Q

Reversal of atropine

A

Physostigmine; patenteral only

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9
Q

Acetylcholinesterase inhibitors

A

Donepezil and Galantamine; inhibits acetylcholinesterase from destroying acetylcholine

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10
Q

Alpha one adrenergic antagonist

A

Doxazosin, prazosin, tamsulosin, alfazosin

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11
Q

Alpha blockers SE/AE

A

Orthostatic hypotension, reflex taxhycardia, sexual dusfunction

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12
Q

Drug used for extravasation and diagnosing a pheochromocytome

A

Phentolamine

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13
Q

Beta adrenergic anatagonists

A

Propanolol, metoprolol, labetalol; blocks beta one receptors, reducing cardiac chronotropy and inotropy

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14
Q

Beta blocker SE/AE

A

Fatigue, bradycardia, and hypoglycemia

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15
Q

Indication of Alpha blockers

A

BPH and HTN

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16
Q

Indications of Beta blockers

A

Angina, HTN, HF, Dysrthmias, migraines prevention, anxiety

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17
Q

What to assess prior adminestering beta blocker

A

HR and BP

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18
Q

Stimulates aloha one adrenergic receptors resulting in vasoconstriction

A

Phenylephrine

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19
Q

Indications of pheynleprhine

A

Shock, hypotension

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20
Q

Increases two adrenergic effects and reducing symphatetic effects

A

Clonidine

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21
Q

Indication of clonidine

A

HTN

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22
Q

Beta one adrenergic agonist that increased cardiac chronotropy and inotropy effects

A

Dobutamine and isoproterenol

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23
Q

Indication of dobutamine and isoproterenol

A

Acute decompensated HF; IV only

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24
Q

Beta two adrenergic agonist resulting in bronchodilation

A

Albuterol

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25
Q

Beta 3 adrenergic agonist resulting in detrusor smooth muscle relation increasing bladder capacity

A

Mirabegron

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26
Q

SE/AE of mirabegron

A

Angioedema, HTN, tachy, urinary retention

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27
Q

First line for alzheimer’s disease

A

Donepezil, galantamine, rivastigmine

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28
Q

Second line for alzheimer

A

Anti-anxiety

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29
Q

Use to treat anticholinergic tox, myastenia gravis and nuero blcoker reversal

A

Physostigmine

30
Q

Other than physostigmine what other drugs can treat myastenia gravis

A

Neostigmine and pyridostigmine

31
Q

Increase dopamine synthesis

A

Levodopa/carbidopa

32
Q

Most effective for Parkinsons disease

A

Levodopa

33
Q

SE/AE of levodopa

A

NV, dyskinesia, OH and psychosis

34
Q

has wearing off effect

A

levodopa

35
Q

activate dopamine

A

Pramipexole, apomorphine for PD

36
Q

SE/AE of pramipexole and apomorphine

A

Constipation, nausea, dizzy, drowsy, insomnia

37
Q

Blocks breakdown of dopamine by blocking MAO-B

A

Selegiline for PD

38
Q

SE/AE for selegiline

A

Insomnia, no tyramine, administer in the AM

39
Q

Blocks the inactivation of dopamine by blcoking COMT

A

entacapone for PD

40
Q

serves to reduce the wearing off effect, added to levodopa

A

Entacapone

41
Q

Treat various severe viruses

A

Interferon beta 1a

42
Q

Treat mutiple sclerosis

A

Interferon beta 1b

43
Q

SE/AE of interferon

A

Flu like, hepatotoxic

44
Q

First line for Multiple sclerosis

A

Interferon

45
Q

What other drugs are used for Mutiple sclerosis

A

Monoclonal antibodies and immunosuppressants

46
Q

Drugs used for spasticity

A

Baclofen, carisoprodol, methocarbamol, and cyclobenzaprine

47
Q

Skeletal muscle telaxant that has anticholinergic effect

A

Cyclobenzaprine

48
Q

Durgbused for malignant hyperthermia

A

Dantrolene

49
Q

Black box warning for dantrolene

A

Hepatotoxic

50
Q

Other indicated used for benzo

A

Muscle relaxant

51
Q

muscle inactivition

A

Onabotulinumtoxin A

52
Q

activates GABA

A

Benzo

53
Q

Drugs under benzo

A

Lorazepam, diazepam

54
Q

SE/AE of benzo

A

muscle weakness, hypotension, sedation, muscle relaxant

55
Q

First line for seizure

A

Benzo

56
Q

Reversal of benzo

A

Flumazenil

57
Q

Prolong sodium channel inactivation

A

Phenytoin, fosphenytoin

58
Q

SE/AE of phenytoin and fosphenytoin

A

Dysrthmia and hypotension

59
Q

Phenytoin can reduce what? And may cause what?

A

Vitamin K, bleeding

60
Q

Blocks specific calcium channels causes seziure threshold

A

Ehthosuximide

61
Q

Barbiturates

A

Phenobarbital

62
Q

SE/AE of phenobarbital

A

Respiratory depression and sedation

63
Q

For seizure, migraine and bipolar

A

Valproate

64
Q

Black box of Valproate

A

Hepatotoxic, teratogenic and pancreatitis

65
Q

Can present with neuro effects upon initial of treatment

A

Carbamazepine

66
Q

BBW of carbamazepine

A

SJS/TEN, aplastic anemia, agranulocytosis

67
Q

best option for seizure in pregnancy

A

Lamotrigine and levetiracetam

68
Q

BBW of lamotrigine

A

SJS/TEN

69
Q

For post-herpetic neuralgia

A

Gabapentin

70
Q

Off label for migraine, anxiety and neuropathic pain

A

Gabapentin