Exam 1 Flashcards
ADPIE
Assessment
Diagnosis
Planning
Intervention
Evaluation
5 Rights
Patient
Med
Dose
Time
Route
The 3 Check
CHECK DRUG with MAR when removing from storage
CHECK DRUG when prepping
CHECK DRUG against the eMAR at the bedside
Sound Alike, Look Alike
Medications whose spellings or pronunciations are so similar they could be mistaken for one another
How to avoid drug admin errors
Check 5 rights
3 checks
Check patient variables (age, sex)
Reading back orders
Don’t rush
Polypharmacy
Multiple prescriptions, sometimes for the same condition, that have conflicting pharmacological actions
Avoid by: getting patient information from healthcare and documentation (med reconciliation)
Medication reconciliation
Checking what meds they are taking, so that there is one solid list and drugs dont interact in a way that could be harmful
Making sure patients know each med and how to take them and what not to take them with
E-prescribing
Use of electronic Rx transferred directly from the MD to pharmacy
More reliable than paper prescriptions
Cant do this with narcotics
Barcoding
Use of a barcode scanner to Identify the patient, the meds, and even the pump
Pharmacokinetics
The study of how drug moves throughout the body
ADME
Absorption
Distribution
Metabolism
Excretion
Absorption
Movement of a substance from site of administration across body membranes to circulation fluids
Determines how long before the drug shows it effect (onset)
Things that determine absorption rate:
- size
- form (liquids absorbed faster)
- lipid- soluble absorbed faster
- metabolism
- drug/drug or drug/food interactions
Distribution
The transport of pharmacological agents through the body
Things that influence distribution:
- blood flow
- lipid soluble drugs more easily distributed
- tissues can store drugs
Blood Brain Barrier
A group of tight junctions that keep the brains blood flow separate from the rest of the body
Sedatives, anti-anxiety (can pass)
Anti cancer drugs (cannot cross)
Metabolism
“Biotransformation”
Changing the medication to a form more easily excreted by the body
LIVER!!! Primary organ for metabolism of drugs
Enzymes in liver can:
- inactivate drugs for easy excretion
- biotransform to result in more active medication
Could cause first pass effect
First pass effect
The medication may be rendered inactive as it goes through the liver
Oral will go to liver before it gets to the bloodstream (makes effects less reliable)
IV ensures that medication is sent straight to bloodstream
Excretion
The removal of drugs from the body
KIDNEY (primary organ for excretion)
Also lungs (anesthetics), bile (poop), and glands(saliva, sweat)
Water soluble drugs more easily excreted than lipid soluble
Loading Dose
Usually a higher dose of the med given one time
- given to quickly achieve therapeutic level
Maintenance Dose
The daily dose that a patient will take as long as they are on the drug to keep plasma levels constant
Therapeutic Range
The dosage range or serum concentration that achieves the drugs desired effects
Onset, peak, duration
- gives us the chance to see how often to give drug and how much to give
Therapeutic Index
Range between a drugs lethal dose and its effective dose
Half-life
Length of time required for the plasma concentration of drug to decrease by one-half after administration
-helps determine time we need to give another dose
Half life abbreviations
Qd (every day)
Qid (4 times a day)
Tid (3 times a day)
Bid (2 times a day)
Pharmacodynamics
How does the medicine change the body
Receptor drugs
A macromolecule (protein) to which a medication binds to produce an effect
Signals a reaction within the body or can block a reaction from happening
Agonist
A drug that mimics the effect of an endogenous molecule
Partial agonist - produces a weaker response
Antagonist
A drug that occupies the receptor and blocks the endogenous molecule action
Lactating clients drug restrictions
Stay away from drugs that can enter the breast milk
- H2O soluble lower levels in BM
- Protein bound drugs bind to mom
Recommendations:
- give drugs w shorter half life
- use non-pharmacological alternatives
Teratogen
An embryo or fetus is exposed to a substance, organism, or physical agent that can produce a permanent abnormality
Children’s drug restrictions
Determined by child’s weight
Older adults drug considerations
More likely to have polypharmacy
- drug/drug interactions
- side effects
Need more help administering drugs