Exam 1 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

MR - Brain
Why are patient studies useful?

A

They are a major source of knowledge about the brain and mind

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MR - Brain
Define agnosia

A

Loss of ability to recognize objects, people, sounds, shapes, or smells; that is, the inability to attach appropriate meaning to objective sense-data

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MR - Brain
Define aphasia

A

A general term relating to loss of language ability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MR - Brain
Define apraxia

A

A general term for disorders of action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MR - Brain
Define amnesia

A

A lack of mnenomic abilities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MR - Brain
Define Ataxia

A

Poor coordination and unsteadiness due to failure to regulate the body’s posture, and strength and direction of limb movements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MR - Brain (not essential)
There are many subtypes of neurological disorders such as agnosia, give examples and definitions of three subtypes

A

Form agnosia - patients percieve only parts of details, not the whole object

Finger agnosia - The inability to distinguish the fingers on the hand. Present following lesions to occipital lobe.

Simultanagnosia - Patients can recognize objects or details in their visual field, but only one at a time

Associative agnosia - Patients can describe visual scenes and classes of objects but still fail to recognize them.

Apperceptive agnosia - Patients are unable to distinguish visual shapes and so have trouble recognizing, copying, or discriminating between different visual stimuli.

Prosopagnosia - also known as facial blindness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MR - Brain
What can the existence of selective deficits tell us?

A

They can tell us something about the way function is organised in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MR - Brain
Define ‘dissociated’ in terms of cognitive functions

A

Seperated to a degree from each other through selective impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MR - Brain
Dissociation studies require what?

A

A minimum of two groups and two tasks. Comparison between patient/control groups shows deficit.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MR - Brain
What are the limitations of single dissociation?

A

In this study, its possible that the poor performance of patients was caused by another factor, such as a deficit in concentration, and that their test of declarative memory required more concentration than our test of nondeclarative.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MR - Brain
What is the benefits of testing for double dissociation?

A
  • Provide strong evidence that there are cognitive processes critical for task X that are not critical for task Y, and vice versa, and that brain area A is critical for task X but not for task Y etc.
  • Double dissociations provide evidence that the observed differences in performance reflect functional differences between the groups, rather than unequal sensitivity of the two tasks.
  • Participants don’t have to be perfectly intact on either task, they just need to be significantly better at one task than the other
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MR - Brain
What are the limitations of patient studies? (5)

A
  1. Assumption of modularity
  2. Lesions extensive and varied
  3. Lesion anatomy inaccurate, connections not considered
  4. Individual differences in functional anatomy
  5. Poor temporal resolution
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MR - Brain
Limitations of patient studies: Explain ‘Assumption of modularity/modularity of function’

A
  • Assumption that mental processes occur with a high degree of isolation from other mental processes and when one area is damaged other regions do not adapt their function
  • Brain plasticity: In reality the brain reorganizes quickly. Intact regions change their behaviour so it is difficult to infer function of damaged region
  • Processes/dynamics neglected: It is neurons, not black boxes, that perform the function - but how?
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MR - Brain
Limitations of patient studies: Explain ‘lesions extensive and varied’

A
  • Most work done with patients who have large lesions
  • Lesions often damage several function centres, so there are few patients with ‘pure’ deficits
  • Lesion size and location variable, hard to find a group of similar patients. Inferences from single patients are weak
  • Individual differences in recuperative history
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MR - Brain
Limitations of patient studies: Explain ‘Lesions anatomy inaccurate and connections not considered’

A
  • Anatomical scans show regions that are destroyed, but intact regions may not be functioning
  • Regions may be disconnected from other regions that provide input
17
Q

MR - Brain
Limitations of patient studies: Explain ‘Individual differences in functional anatomy’

A
  • We assume that an anatomical region of the brain does the same function in all individuals
  • Clearly violated assumption - e.g. Wada test indicates left hemisphere predominates in language processing in most, but not all, individuals
  • Variability of function across individuals reduces the power of group studies
18
Q

MR - Brain
Limitations of patient studies: Explain ‘Poor temporal resolution and experimental control’

A
  • Even if patient studies establish which regions are necessary for a task, and its inferred cognitive processes, it is not possible to infer the stages of processing
  • A memory deficit may arise from a failure of encoding, retention or recall
  • There is no experimental control over lesion location, but animal studies using experimental ablation can provide this
  • Other methods overcome these limitations
19
Q

MR - Brain
What are the benefits of patient studies?

A
  • Show which areas are necessary for a particular cognitive function (double dissociation)
  • Show cognitive, emotional, social consequences of a deficit
  • Cost and time effective, single case studies are possible (eg HM, no experimental design necessary, exploratory observations possible)
  • Can be done right (overlay plots and control groups) to limit criticism
20
Q

MR - Brain
Why can we not localise speech production in this (Broca’s) area?

A
  • Damage is not limited by functional boundaries
  • Lesion might be smaller than functional module
  • Interindividual differences in brain organisation
  • Result might reflect increased vulnerability of region to injury (eg because of vasculature)
  • Area might just be interconnected with the actually relevant area (indirect disruption)
21
Q

MR - Brain
What does fMRI stand for?

A

Functional Magnetic Resonance Imaging

22
Q

MR - Brain
How do MRI machines work (the physics)?

A
  • Uses a magnetic field (Bo) and radio energy to produce an image
  • A large magnet (50,000 x Earth) aligns nuclei that have a net magnetic moment (from odd number of protons/neutrons)
  • Nuclei absorb and re-emit radio frequency energy
23
Q

MR - Brain
How is an image acquired in an MRI?

A
  • Nuclei spin around the main magnetic field
  • RF pulse (oscillating magnetic field) tips M out of alignment with Bo and synchronises the phase of spins
  • M gradually returns to alignment and spins lose phase coherence. These changes are detected as the ‘MRI’ signal
24
Q

MR - Brain
What can mapping changes over time look at?

A
  • Grey matter volume
  • Commisural myelination
25
Q

MR - Brain
What does BOLD stand for? (in fMRI)

A

The Blood Oxygen Level Dependent (BOLD) response

26
Q

MR - Brain
What is BOLD?

A

It is the basis of fMRI

The neural events are evident from a change in the blood level in the brain (haemodynamics) - Simple explanation