Exam #1 Flashcards
What is the endocrine system?
The releasing of hormones that act on a specific site
What releases hormones?
Glands
What is the difference between an endocrine and exocrine gland?
Exocrine glands secret hormones to be used nearby where as endocrine glands secrete hormones into the blood that will be used somewhere in the body
What is a half life?
Length of time needed for half of the drug or chemical to be degraded by half
How long does a lipid based hormone last?
Hours to days
How long does a protein based hormone last?
Minutes
What type of hormone last the longest in the body lipid based or protein based?
Lipid based
Where do hormones attach on cells?
On a specific receptor site that fits a certain hormone like a key
What is conjugation of a hormone mean?
This occurs when a plasma protein is bonded to a hormone to increase half life
What is a beta blocker?
A beta blocker is drug that attaches to a receptor that prevents drugs/hormones from binding to the receptor site
What are hormone receptors made of ?
Proteins
What do we look at to distinguish different types of receptors?
Hormones they recognize,
Their method of information transfer after the hormone is bound to the cell
Location within the cell
What are some characteristics of a hormone that binds to the surface of a cell?
Known as secondary messengers
Includes almost all of protein or amino acid hormones
The hormone binds to a membrane protein
Short acting hormones….seconds to minutes
What are some characteristics of a steroid that binds inside of the cytoplasm?
Hormones enter the plasma membrane and bind to the receptor
Relatively long acting hormones…hours to days
What are some characteristics of thyroid hormones that bind to nucleus receptors?
T3 and T4 hormones
Enters the nucleus and binds to that receptor
Complex association with DNA and transcription
What are prostaglandins? ???????
A hormone like substance used by the body to ……..
What is the hypothalamus?
The endocrine systems link to the nervous system
Where is the hypothalamus located?
Located at the base of the brain below the thalamus but above the pituitary gland
What does the hypothalamus do?
Regulates homeostasis by controlling growth, emotions, salt and water balance, sleep, weight, and appetite
Where is the pituitary gland?
The gland that is directly connected to the hypothalamus
What type of connection does the posterior pituitary gland have to the hypothalamus?
Neural connection
What type of connection does the anterior pituitary gland have to the hypothalamus?
Blood connection
What are the hormones released from the posterior pituitary gland?
Antidiuretic hormone and oxytocin
What does antidiuretic hormone do?
Promote water retention by the kidneys
What does oxytocin do?
Proteomes uterine contractions during the delivery of a baby
Sustains uterine contractions after birth
Promotes lactation, social bonding, and sexual arousal
What are the hormones released by the anterior pituitary gland?
Growth hormone/ Somatotropin
Thyroid stimulating hormone
Adrenocotrotropic hormone
Prolactin
Luteinizing Hormone
Follicle Stimulating Hormone
Lipotropins
Beta Endorphins
Melanocyte Stimulating Hormone
What does growth hormone do for the body?
Causes uptake of protein and breakdown of fat
Promotes bone and cartilage growth
Released if blood sugar is too low
Released during times of stress
What does thyroid stimulating hormone do?
Causes release of thyroid hormones
Promotes growth and development of thyroid
What does Adrenocorticotropic hormone do?
Stimulates cortisol secretion from adrenal cortex
Increases skin pigmentation
What does prolactin do?
- target tissue is mammary gland and ovaries
- leads to milk production in women (male fxn. ukn.)
- stimulated by nursing, high estrogen levels or low levels of estrogen & progesterone (low levels of both would occur following delivery)
- inhibited by progesterone or a combination of high estrogen & progesterone levels
What does Luteinizing hormone do?
target tissue: ovary in females, testes in males
- females: ovulation and progesterone production
- males: testosterone production & support sperm production
What does Follicle-stimulating hormone do?
- target: follicles in ovary for women; seminiferous tubes (within the testes) in men
- females: follicle maturation, estrogen secretion
- males: spermatogenesis in testes
What are lipotropins?
Targets fat tissues to break them down
What are beta endorphins?
Targets the brain and other places
Helps with pain relief in the brain
What does melanocyte stimulating hormone do?
Results in increased melanin production
Where is the thyroid gland located?
Located on top of the trachea below the larynx
What compound is most important for thyroid hormones
Iodide
What are the two hormones produced by the thyroid?
T 3/4 and Calcitonin
What do T3 and T4 do?
Control metabolism and organ maturation and helps regulate blood calcium levels
What does calcitonin do?
Decreases brown break down by osteoclasts and prevents large increases in blood calcium
What releases calcitonin?
Parafollicular cells
What do osteoclasts do?
They break down bone and release calcium into the blood
What do osteoblasts do?
They build up bone and pull calcium from the blood
What happens to the heart if there is too much calcium?
The heart goes into tetinay
What is goiter?
An iodine deficiency and is visible from enlargement of the thyroid
Where is the parathyroid found?
There are 4 parts on the backside of the thyroid on the corners
What hormone is secreted from the parathyroid?
Parathyroid hormone
What does parathyroid hormone do?
It is releases when blood calcium levels are low
It stimulates osteoclasts to break down bone to release calcium In the blood
When would your body want to release calcitonin?
When calcium levels in the blood are at the perfect level
When would your body want to release parathyroid hormone?
When you do not have enough calcium in the blood
Does calcitonin encourage osteoclasts to work harder or to slow down?
Slow down
Does parathyroid hormone increase osteoclasts activity or decrease?
Increase
What does the pancreas do in relation to the endocrine system?
Helps regulate blood sugar levels in the blood
What hormones does the pancreas release?
Glucagon, somatastatin, and insulin
What does glucagon hormone do?
Released when you blood sugar is too low
It increases the formation of glucose from amino acids and fats
Increases the breakdown of glycogen to glucose in the liver
What percentage of islets are made of glucagon?
20% - 25%