exam 1 Flashcards
what is the definition of genetics?
the science of dealing with heredity and variation, seeking to discover laws governing similarities and differences in individuals related by decent
what is the definition of animal genetics?
the study of the principles of inheritance in animals
what is the definition of animal breeding?
the application of the principles of animal genetics with the goal of improvement of animals
what is the purpose of animal breeding?
to genetically improve the economic efficiency of livestock production
what is the purpose of selection?
to improve economic merit through genetics
what is selection?
the determination of parents of the next generation
what does natural selection seek?
genetic fitness
what was the first domesticated animal?
dog
who is know as the father of animal breeding?
Robert Bakewell
what are some effects of inbreeding?
- allows to mate genetically similar animals
- increases homozygosity
- improves uniformity
what did Robert Bakewell use inbreeding for?
the “purebred” concept
why focus on males when breeding a herd of cattle?
they produce more offspring
what test did Robert Bakewell develop an early version of?
bull progeny test
what did domestication do for civilization?
- they dont have to hunt and can spend that time on other things
- allowed civilization to happen
- during drought, they could still eat and keep life going
what were the three major events that led to the development of modern genetics?
- darwin published the origin of species
- mendel publishes experiments in plant hybridization
- miescher isolates nucleic acids from cells
why is a gene so much bigger than an mRNA?
the mRNA has had its’ introns removed
where does splicing happen?
the nucleus
what are two benefits of splicing?
- facilitates nuclear export
- helps with the stability of the molecule
what are the three RNA modifications?
intron splicing, 7 methylguanosinn cap, and poly-A tail
what roles does a 7 methylguanosine cap serve in protein synthesis?
found at the nucleus/ 5’ end to protect RNA from degradation, increases stability, allows for easy binding to the subunit of the ribosome
what protein is central to both the initiation and the elongation of transcription?
RNA polymerase
In the cell, what determines which DNA strand is transcribed?
a promoter
once a DNA strand is transcribed, what determines the open reading frame used for translation?
the position of the start codon (AUG)
where does transcription end?
the poly-A tail (AAA), 3’ end
where does translation end?
the stop codon (UGA, UAA, UAG)
in what direction are RNA polynucleotide transcripts assembled?
5’ to 3’
what orientation, with respect to the transcript, is the template DNA strand?
3’ to 5’
what direction does RNA transcription happen?
5’ - 3’
what has modifications? DNA replication or RNA transcription?
RNA transcription
what catalyzes RNA transcription?
RNA polymerase