Exam 1 Flashcards
Physiology
How body functions together
Homeostasis
Stable points/levels of life
Core concept
Frame of thinking/ principles that apply to overall physiology
Cell to cell communication
How cells coordinate and relay info to each other
Mass balance
How much of a material you have in your body; input and output
Interdependence
Physiological systems’ reliance on each other
Set point
Target level of physioosical variable
Variable
Something under physiological control that can change via internal/external factors. (e.g. Body temp, blood sugar, pH)
Receptor
Measures values of variables
Effector
Responds to into from integration center
Integration center
Receives info from receptor and determines action
Regulated variable
Has sensors that keeps variable within explicit range
Controlled variable
variable that can be changed but no sensor ( e.g. HR, hormone concentration, respiration rate )
Equilibrium
Stable system; physiological variables constant
Steady-state
Specific variable is constant; might require other variables to increase or decrease
Negative feedback loop
Body responds to changes in the system outside the set point in order to return to set point and homeostasis
Positive feedback loop
Body responds to stimulus/signals by reinforcing them ( e.g. Blood clotting, childbirth)
Dehydration synthesis
Reaction in which h2o is produced while making a bond (e.g. Glycolytic bond formation)
Hydrolysis
Reaction that uses h2o to break a bond
Integral membrane proteins
Proteins embedded in lipid bilayer; amphipathic
Transmembrane proteins
type of integral Proteins that cross the entire lipid bilayer; protein channels
Peripheral membrane proteins
Proteins loosely bound to membrane via integral proteins
Chromatin
Loosely coiled DNA and proteins that is contained in nucleus
Osmolarity
Solute particle concentration of a solution
tonicity
Comparison of solute concentration inside and outside the cell
Isotonic
No net flow between cell and solution
Hypotonic
Net fluid movement into the cell; cell swells
Hypertonic
Net fluid movement out of the cell; cell shrinks
Endocytosis
Transport of materials into the cell; requires ATP
Exocytosis
Transport of materials out of the cell; does not require ATP
Phagocytosis
Transport of large molecules into cell; type of endocytosis; e.g. Pathogen removal
Pinocytosis
Transport of fluid particles into cell; type of endocytosis; “cellular drinking”
Simple diffusion
Ion diffuses across membrane due to concentration gradient; spontaneous
Facilitated diffusion
Requires gradient and protein to cross membrane; spontaneous
Primary active transport
Requires energy to move ions against gradient via protein
Secondary active transport
Pump creates gradient via energy, gradient used to pump different molecules against their gradient either into or out of cell; e.g. Symporters and antiporters
Nernst equation
Voltage required to oppose the force of concentration gradient on single ion
4 contributors to resting membrane potential
1) Na influx 2) K efflux 3) na/k pump = 3 k out and 2 Na in 4)negative proteins
Lysosome
Spherical organelle which contains degradative enzymes
Rough endoplasmic reticulum
Protein production
Smooth endoplasmic reticulum
Lipid, phospholipid, steroid, and carbohydrate synthesis
Golgi apparatus
Processing and delivery center
Peroxisomes
Oxidation and FA+AA breakdown
Ribosomes
Protein synthesis
Transcription
DNA to mRNA
Translation
mRNA to protein
mRNA
Comes from nucleus with order complimentary to section of DNA
rRNA
Makes up ribosomes
tRNA
Attached to AA monomer and assist in protein synthesis with mRNA and ribosomes
Glycolysis
Glucose to net 2x pyruvate, 2x ATP, 2x NADH; anaerobic; 10 steps; if oxygen present produces pyrurate, if NO oxygen present produces lactate = no CAC
Linking step
2x pyrurate to 2x AcetylCoA, 2x carbon dioxide, 2x NADH; occurs in mito matrix
CAC/Krebs
2x AcetylCoA through 8 step process to ‘ produce 6x NADH, 2x FADH2, 4x carbon dioxide, 6x water, 2x ATP; technically anaerobic but if no oxygen then no pyruvate = no AcetylCoA; occurs in mitochondrial matrix
Electron Transport Chain
Aerobic process which utilizes established proton gradient along inner membrane space of mitochondria and electrons to produce ATP and water via oxidative phosphorylation
Interphase
Majority of cell cycle; preparation and growth; G1, S, G2
G1
part of interphase in which cell grows and functions, duplicates organelles
S
part of interphase in which DNA replicates, chromosome pairs join at centromere, centrosome duplicates
G2
part of interphase in which cell increases in size, more protein and organelles, preparation for mitosis
Mitosis
Cell duplication; prophase, metaphase, anaphase, telophase,cytokinesis
Prophase
Nucleus dissipates, chromosomes condense, spindle forms
Prometaphase
Spindle begins to attach and move chromosomes; nuclear envelope breaks; chromosomes condensed fully
Metaphase
Daughter chromosomes line up at metaphase plate; enzyme breaks down chromatids
Anaphase
Daughter chromosomes polled to opposite poles of cell
Telophase
Chromosomes uncoil; spindle breaks down; nuclear envelopes form
Cytokinesis
Cell division; 2 daughter cells; begins during anaphase or telophase; finishes after telophase; contractile ring pinches together
Primary functions of nervous system
Receive info about environment; process info; respond to info
Efferent
Exit brain
afferent
At brain (towards)
Autonomic nervous system
Part of CNS that is involuntary
Somatic nervous system
Part of CNS that is voluntary
Sympathetic nervous system
Part of autonomic of CNS that is fight or flight; norepinephrine
Parasympathetic nervous system
Part of autonomic of CNS that is rest and digest; acetylcholine
Visceral sensory
Input from organs
Somatic sensory
Temperature, pain, movement, body position, touch
Temporal summation
Single neuron sends the same signal repeatedly over time
Spatial summation
Multiple neurons send a signal at the same time within proximity