EXAM 1 Flashcards
Stages of Embryonic & Fetal Development
Ovum released from ovary; passes into open fallopian tube; starts journey downward toward the sperm for fertilization
- preembryonic stage
- embryonic stage = (MOST CRITICAL TIME)
- fetal stage
what is the preembryonic stage
fertilization through second week
- fertilization = takes place in the fallopian tube.
- union and eggs and ovum forms a zygote (46 chromosomes)
- blastocyst = inner cell ( EMBRYO AND AMNION )
- trophoblast= outta cell ( CHORION AND PLACENTA
chorion ( outer most cover of the embryo (amnion fluid)
- implantation
Embryonic stage:
end of second week through eighth week
- MOST CRITICAL TIME In EMBRYONIC DEVELOPMENT
- basic structures of major body organs and main external feature
Fetal stage
end of the eighth week until birth
how long does gestation (period of pregnancy) last
Lasts approximately 280 days or 10 lunar months = 9 calendar months
37 to 42 weeks
normal term timeframe of gestation
37 to 42 weeks
Naegle’s Rule:
Last mentrual period (LMP) + 7 days – 3 months = estimated due date (EDC)
what weeks are most crucial in regards to development
The first 8 weeks are the most crucial in regards to development.
neural tube defects up to how many weeks
6 weeks
and it happens due to low FOLATE ACID INTAKE
when does cleft palate form
early, 5-6 weeks
when does the heart develop
between weeks 3-8
funtions of the placenta
- Serving as the interface between the mother and fetus
- Making hormones to control the physiology of the mother
- Protecting the fetus from immune attack by the mother
- Removing waste products from the fetus
- Inducing the mother to bring more food to the placenta
- Producing hormones that prepare fetal organs for life outside of uterus
- Does metabolic functions of: respiration, nutrition, excretion, storage of nutrients
- THE PLACENTA TAKES OVER THE FUCNTIONS OF THE LUNGS, KIDNEYS DURING FETAL LIFE SO LARGE VOLUME OF OXYGEN NOT NEEDED
hormones of the placenta
hCG (human chorionic gonadotropin) = preserves corpus luteum and its progesterone production maintains the endometrium lining of the uterus is maintained.
Human placental lactogen (hPL) or human chorionic somatomammotropin (hCS) = decreases maternity insulin sensitivity which leads to increase in availability for fetal nutrition
Estrogen = stimulates myometrial contractility Progesterone = decrease contractility of the uterus, maintains endometrium Relaxin = soften the cervix and causes relaxation
Miscarriage occurs if ….. stops functioning
corpus luteum
function of the human chorionic gonadotropin (hCG)
preserves the corpus luteum and its progesterone production so that the endometrial lining of the uterus is maintained; this is the basis for pregnancy tests
basis for pregnancy test
hCG ( human chorionic gonadotropin )
fucntion of the hPL (Human placental lactogen )
modulates fetal and maternal metabolism, participates in the development of maternal breasts for lactation, and DECREASES maternal insulin sensitivity to INCREASE its availability for fetal nutrition
fucntion of Progesterone (progestin
maintains the endometrium, DECREASES THE CONTRACTILITY of the uterus, stimulates MATERNAL METABOLISM and breast development, provides nourishment for the early conceptus
Relaxin fucntion
acts synergistically with progesterone to maintain pregnancy, causes relaxation of the pelvic ligaments, softens the cervix in preparation for birth (Freemark, 2015).
what is the significance of the veins and arteries in the umbilical cord ( one large vein and two small arteris)
A-V-A
- the Vein carries OXYGENATED blood to the FETUS
- Arteries carry DEOXYGENATED blood to the PLACENTA
what could only one artery and vein signify?
COULD SIGNIFY CONGENITAL MALFORMATION of renal or cardiac nature
function of the wharton jelly that surrounds the vein and arteries of the umbilical cord
it prevents compression & gives nutrition
where does the umbilical cord orginates from
Originates from the connecting stalk
- At week #5 the stalk is compressed by the amnion and forms the narrow part of the umbilical cord.
SO THE UMBILICAL CORD IS FORMED FROM THE AMNION
AMNIOTIC FLUID FUNCTION
- Helps maintain a constant body temperature for the fetus
- Permits symmetric growth and development
- CUSHION FROM TRAUMA
- BARRIER TO INFECTION
- allows the UMBILICAL CORD to be relatively free of COMPRESSION
- Promotes fetal movement to enhance MUSCULOSKELETAL MOVEMENT
- repository for waste
- source of oral fluid
composition of amniotic fluid ( increases weekly )
large part is fetal urine which means the amount of amniotic fluid is a result of how functional the renal is
= fluid from the respiratory and GI tracts of the fetus also enter the amniotic cavity
what is fetal circulation
blood from the placenta to and through the fetus and then back to placenta
Three shunts during fetal life:
- Ductus venosus: connects the umbilical vein to the inferior vena cava
- Ductus arteriosus: connects the main pulmonary artery to the aorta
- Foramen ovale: anatomic opening between the right and left atrium
Foramen ovale:
anatomic opening between the right and left atrium
ductus venosus fucntion
connects the umbilical vein to the inferior vena cava
function of the ductus arteriosus
connects the main pulmonary artery to the aorta
Neonatal Cardiovascular Physiological changes
↓ Pulmonary resistance leads to ↑ pulmonary blood flow leading to ↑ systemic vascular resistance
Ductus venosus closure
Foramen ovale closure
Ductus arteriosus closure
Human somatic cells contain
46 chromosomes arranged as 23 pairs of homologous
chromosomes
- Each “pair” has one set of chromosomes from each parent.
- 22 pairs of autosomes
- 1 pair of sex chromosomes
A gene is considered “dominant”
2 slightly different genes at the same location are expressed; called heterozygous (i.e. brown eyes are dominant over blue eyes)
what is Autosomal dominant inherited
Autosomal dominant inherited disordersoccur when a single gene in the heterozygous state is capable of producing the phenotype. In other words, the abnormal or mutant gene overshadows the normal gene and the person will demonstrate signs and symptoms of the disorder.
what is Autosomal Recessive Inheritance
Autosomal recessive inherited disordersoccur when two copies of the mutant or abnormal gene in the homozygous state are necessary to produce the phenotype. In other words, two abnormal genes are needed for the individual to demonstrate signs and symptoms of the disorder. Both parents of the affected person must be heterozygous carriers of the gene (clinically normal but carriers of the gene).
what is X-linked Recessive Inheritance
X-linked inherited disordersare those associated with altered genes present on the X chromosome.
what is X-linked Dominant Inheritance
X-linked dominant inheritance occurs when a male has an abnormal X chromosome or a female has one abnormal X chromosome
Abnormalities of chromosome number
Monosomies; trisomies
Polyploidy
what are some abnormalities of chromosome structure
Deletions
Inversions
Translocations
Signs and Symptoms of Pregnancy
Presumptive
Probable
Positive
what is the presumptive sign and symptom of pregnancy
- Signs women experiences that make her think she might be pregnant
- Least reliable, can be caused by other conditions
what is the probable sign and symptom of pregnancy
- Changes that can be detected on physical exam by a health care provider
- Can still be caused by other conditions
what is the positive sign and symptom of pregnancy
- Signs that are directly attributed to the fetus
- Can be explained only by pregnancy
what is the Goodell’s sign
An indication of pregnancy in which the cervix and vagina soften
what is the hegar’s sign
a non-sensitive indication of pregnancy in women.
its absence does not exclude pregnancy. It pertains to the features of the cervix and the uterine isthmus. It is demonstrated as a softening in the consistency of the uterus, and the uterus and cervix seem to be two separate regions.
what is the Chadwick’s sign
an early sign of pregnancy
It occurs when blood flow to the cervix and vagina increases around the fourth week of pregnancy, causing those tissues to become purplish-red.
limitations of home pregnancy tests.
tests in sensitivity, specificity and accuracy
Influenced by length of gestation, specimen concentration, presence of blood, and presence of some drugs
what does the elevation of hCG corresponds to
corresponds to the morning sickness period of approximately 6 to 12 weeks during early pregnancy.
hCG levels in normal pregnancy.
Human chorionic gonadotropin (hCG) is the earliest biochemical marker for pregnancy
- it doubles every 48 to 72 hours.
this helps differentiate normal from abnormal pregancy
what are some situations that intefere with the accuracy of the fundus height
Obesity, hydramnios, and uterine fibroids
what is the fundus height
measurement from the symphysis bone up to the xiphoid process.
- it is most accurately between 18 and 32 weeks .
- height of top of the uterus in cm = # of gestational weeks. fundal height by 20 weeks at gestation level of umbilicus (20 cm)
uterus adaptations during pregnancy
- Increases in size ofc
- Changes shape: pear to ovoid
- Positive Hegar’s sign
- Ascends into abdomen after first 3 months
cervix adaptations during pregnancy
- Softens (Goodell’s sign)
- Mucous plug forms
- Increased vascularization (Chadwick’s sign)
- Ripening about 4 weeks before birth
vagina adaptations during pregnancy
- Increased vascularity with thickening
- Lengthening of vaginal vault
- Secretions more acidic, white, and thick; leukorrhea
ovaries adaptation during pregnancy
- Enlarge until 12th to 14th week of gestation
- Ovulation and menses cease
breast adaptations during pregnancy
- Breasts increase in size and areolar pigmentation; nipples become more erect
- Tubercles of Montgomery (sebaceous glands) become prominent. Keep nipples lubricated for breastfeeding
- Blood vessels more prominent; blood flow to breasts doubles
PRODUCE COLOSTRUM after 12th week - COLOSTRUM: antibody-rich, yellow fluid
colostrum converts to mature milk after delivery
what minerals are usually insufficient and needs to be supplemented for the demands of pregnancy
Many women enter pregnancy with insufficient iron stores and thus need supplementation to meet the extra demands of pregnancy.
pulse and pregancy
increase of 10-15 bpm
blood pressure during pregnancy (1st Trimester)
at pre-pregnancy levels
2nd Trimester: Sl. ↓
3rd trimester: return to prepreg. levels
blood pressure during pregnancy (2nd Trimester)
SI decreases
blood pressure during pregnancy (3rd Trimester)
return to pre-preg. levels
Blood volume during pregnancy
INCREASE by 1500 ml or 40-50% above prepreg. Level
- The rise in blood volume correlates directly with fetal weight, supporting the concept of the placenta as an arteriovenous shunt in the maternal vascular compartment.
RBC during pregancy
increase by 17%
hemoglobin and hematocrit during pregnancy
decreases because the plasma becomes more than the red mass cell
another way to think of it.
fluid deficit or dehydration causes hemoglobin and hematocrit to INCREASE! so this the opposite
cardiac output during pregnacy
↑30-50%
Sl. cardiac hypertrophy
Supine Hypotension Syndrome
the vena cava and the aorta are between the uterus and the spinal cord so if the pregancy lady lays supine, the uterus compresses them.
- it is rather advisable to lay in the side-lying position
expiratory volume during pregnacy
decreases whiles inspiratory INCREASES
vital capacity during pregancy
DOES NOT CHANGE
tidal volume during pregnancy
↑ 30-40% resulting hyperventilation & lower PCO2. This lower PCO2 leads to maternal resp. alkalosis facilitating transfer of CO2 from fetus to mother
BMR during pregnancy
↑ 15-20%
Renal System Changes during pregnancy
Renal pelvis become dilated & The ureters (especially the right ureter) elongate, widen, and become more curved above the pelvic rim.
- Glucoseurea in 20% of pregnant women
- bladder capacity increases time 2
- GFR & renal plasma flow ↑ from ↑ hormones & ↑ blood volume (Renal plasma flow ↑ 30%; GFR ↑ 40-60%)
creatine levels during pregancy
DECREASES
Musculoskeletal System: Maternal Postural Changes
- Due to change in center of gravity
- Shoes can make a difference in balance
- May have balance issues due to anemia, medications, etc.
- Key is to counsel woman about shoes, posture, good body mechanics
- Calcium storage
- Postural changes
- Abdominal wall
Integumentary System Changes
↑ in skin thickness & subdermal fat ↑ hair & nail growth ↑ sweat & sebaceous gland activity ↑ circulation & vasomotor activity ↑ fragility of elastic tissue causing striae gravidarum (stretch marks) - Pigment changes (linea nigra,chloasma) - Tiny, bright red angiomas Nevi, hirsuitism, softer nails
VASCULAR-RELATED SKIN CHANGES during pregnancy
Vascular changes during pregnancy manifest in the integumentary system include varicosities of the legs, vulva, and perineum. Varicose veins are commonly the result of distention, instability, and poor circulation secondary to prolonged standing or sitting and the heavy gravid uterus placing pressure on the pelvic veins, preventing complete venous return.
Interventions to reduce the risk of developing varicosities include
- Elevating both legs when sitting or lying down
- Avoiding prolonged standing or sitting; changing position frequently
- Resting in the left lateral position
- Walking daily for exercise
- Avoiding tight clothing or knee-high hosiery
- Wearing support hose if varicosities are a preexisting condition to pregnancy
Gastrointestinal Changes during pregnancy
- Estrogen causes ↑ blood flow to mouth leading to gums being more friable & leads to ↑ gingivitis
- saliva is more acidic
- Fetus gets calcium from maternal stores NOT from her teeth
- Progesterone causes smooth muscle relaxation leading to ↓ tone of lower esophageal sphincter w/resultant reflux & heartburn
- Estrogen ↑ influences gale bladder leading to stasis of bile salts (cholestasis of pregnancy resulting in pruritis & icterus
- smooth muscle relaxation leads to ↓ motility & prolonged emptying time & complete intestinal tract in sm. intestine leads to ↑ absorption of minerals, nutrients & drugs
- smooth muscle relaxation leads to ↓motility of the Lg. intestine leading to constipation as slow transit time leads to ↑ water absorption & flatulence
Gum Fragility in Pregnancy
- Bleeding of gums during pregnancy results from increased estrogen levels that cause blood vessel proliferation. This then leads to increased blood vessels in the gums and an increased chance of bleeding.
endocrine controls during pregancy
- integrity and duration of gestation by maintaining the corpus luteum via hCG secretion;
- production of estrogen, progesterone, hPL, and other hormones and growth factors via the placenta;
- release of oxytocin (by the posterior pituitary gland), prolactin (by the anterior pituitary), and relaxin (by the ovary, uterus, and placenta).
Immune System during pregnancy
- Immune system undergoes complicated immune system adaptation
- A general enhancement of innate immunity (inflammatory response and phagocytosis) and SUPPRESSION of adaptive immunity (protective response to a specific foreign antigen) take place during pregnancy.
- Involves maternal organism becoming “tolerant of the foreign” fetus keeping fetus from being rejected & protecting it from infection
**These immunologic alterations help prevent the mother’s immune system from rejecting the fetus (foreign body), increase her risk of developing certain infections, and influence the course of chronic disorders such as autoimmune diseases.