EXAM 1 - 10 Lectures Flashcards
health
the state of an organism when it functions optimally without evidence of disease or abnormality
disease
deviation from normal function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs
pathogen
any disease-producing agent or microorganism
etiology
cause of disease
wildlife diseases
are multifactorial and can involve complex interactions between the pathogen, host, and environment
vary within and between populations
spectrum of disease
increasing with changing and loss of biodiversity
- increasing interaction
- improved diagnostics and surveillance
one health
concept recognizing that the health of humans is connected to the health of wildlife, domestic animals, and the environment
reason to study wildlife diseases
wildlife impact and management
- determine the cause of and significance of disease and identify methods to reduce disease and the impacts on wildlife
- endangered species may suffer disastrous losses from disease
disease of human or agricultural significance
- determine role of wildlife as a reservoir or source of disease for domestic animals or humans
environmental health or habitat loss
- can be indicators of contaminated habitats - can be associated with habitat loss
disease of high visibility and/or concern
- public communication
assess the role of humans on wildlife health
to learn
how do we investigate wildlife diseases
study the impacts of disease on individuals and/or populations
challenges with wildlife disease investigations
detection of sick and dead animals
difficulty obtaining samples for surveillance
difficulty quantifying disease
lack of knowledge
funding
lack of validated test
problems related to science and technology
managing wildlife diseases
do we have to?
very challenging and often unsuccessful
- public attitude
- delivery of treatment
prevention
prevent disease from occurring or becoming establised
control
reduce or maintain the prevalence and impact of disease
eradication
eliminate the pathogen or disease
difficult or cannot be done
pathology
the study of disease, especially the structural and functional changes produced by them
extremely useful in wildlife diseases
- clinical signs often absent, subtle, nonspecific
- history may not be available
pathogenesis
mechanism of disease
morphologic changes
structural changes in cells or tissues characteristic of disease
clinical significance
how morphologic changes result in clinical signs and disease
clinical pathology
more focused on antemortem samples/data
results from lab tests - fluids
cytology
less commonly used for wildlife disease
cytology
clinical pathology
microscopic examination/evaluation of cells
anatomic pathology
necropsy
histology
necropsy
postmortem examination of the body
histology
microscopic examination of structure, function, and morphology of tissues
lesions
abnormal change in structure of organ, tissue, or cell due to disease
not all abnormal appearing tissues are lesions
distribution provides insight into pathogenesis and potential etiology
focal
single lesion
multifocal
numerous lesions
locally extensive
one lesion expanding outward
effusions
escape of fluid into a space or cavity from tissue or organ
beginning - named for composition
end - named for location
aspirate
hemorrhage
escape of blood from damaged or dysfunctional blood vessels
due to damage to blood vessels, blood clotting disorders
can be primary or secondary
may bee seen with edema or musculoskeletal lesions
necrosis
death of cells or tissue
can look different depending on tissue, cause, and duration of lesion
often pale, soft, friable, and demarcated margins
can look read if vasculature involved
inflammation
protective response to a diversity of cell injuries
-itis
can be associated with infection
acute or chronic
acute inflammation
consists of vascular and cellular components
- increase blood flow
- increase blood vessel permeability
- migration of permeability
- leukocyte recruitment
accumulation of fluid and inflammatory cells
- remove cause of injury
- healing and repair
signs
- rubor - red
- tumor - swelling
- calor - hoot
- dolor - pain
- laesa - lose of function
chronic inflammation
lymphocytes, macrophages, plasma cells infiltrate injured area
tissue destroyed by inflammatory cells
repair with fibrosis and angiogenesis
peracute
faster than acute
lightning, trauma, infection
may not have lesions - died too quickly
neoplasia
unregulated cell proliferation
some are spontaneous
uncommon in wildlife - don’t live long
most often associated with infectious agents
other etiologic factors
- chemicals
- diet
- irradiation
- hormones
- genetic inheritance
- pharmacologic agents
tumor
any tissue mass
benign or malignant
benign
ends in - oma
slower growth rate
not locally invasive
not likely to metastasize
well differentiated
malignant
- carcinoma - if ectodermal or endodermal
- sarcoma - if affecting connective or soft tissue
fast growth rate
locally invasive
more likely to metastasize
poorly differentiated
pathology challenges for wildlife cases
not all abnormal tissues are lesions
normal anatomy
- extremely diverse
- seasonal changes
post-mortem change
artifact
parasites
distinguishing between antemortem vs postmortem changes
autolysis
artifact
changes in tissue that occur right at the time of death or soon after
euthanasia
autolysis
disintegration of cells or tissues by endogenous enzymes
postmortem
not necrosis - cell death
epidemiology
the study of the distribution and determinants of health-related events in a population
utilization of this information for diagnosis, prevention, control of disease
distribution
who, what, when, where, why
defining disease/health issue
understanding circumstances that result in disease event
determinants
risk factors
types of epidemiology
descriptive
analytical
descriptive epidemiology
examine and characterize the distribution of disease in a population
analytical epidemiology
investigating a hypothesis about the cause of disease by studying how exposures relate to disease
modeling
interface
a point where two systems can meet and interact
share diseases
enzootic disease
occurs in a population at a regular, predictable, or expected rate
endemic
epizootic disease
appears at a time or place where it does not normally occur or with a frequency substantially greater than expected
epidemic
prevalence
frequency of occurrence of disease within a group at a specific point in time
period prevalence - with a period of time
incidence rate
number of new cases within a group during a specific period of time
mortality rate
frequency of occurrence of death in a defined population during a specific time interval
case fatality rate
proportion of persons with a disease that die
measure of severity
only in infected
pathogenesis
development of a disease and the chain of events leading to that disease
mechanism
risk assessment
process to identify hazards/threats and analyze what could happen if they occur
probability of disease/infection occurring
consequences of disease/infection
can we manage
clinical sign
objective evidence of disease observed by a medical professional
syndrome
combination of clinical signs resulting from a single cause
congenital
disease that is present at or before birth
acquired
disease that occurred or was acquired after birth
differential diagnosis procedure
systematic diagnostic method t identify the etiology of disease where multiple possibilities exist based on clinical signs or symptoms
compile information
create a list of possible etiologies - rule outs
formulate a diagnostic plan - priority testing
sue diagnostic results to remove or add to list
diagnostic success is influenced by
well defined objectives
detailed history
appropriate samples
diagnostic assay
diagnosotic assays
direct and indirect
direct assay
identification of etiology itself
indirect assay
identification of measurable response too the etiology
ideal diagnostic assay
well-characterized
affordable
user friendly
rapid
sensitive and specific
minimal equipment
widely available
works on all species
test sensitivity
number of positive samples correctly classified as positive
test specificity
number of negative samples correctly classified as negative
bloodwork and urinalysis
not used frequently in wildlife
requires live or recently dead animals
need normal values