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065. My HDM Exam 2 > EX: Cytokine Function and Site > Flashcards

EX: Cytokine Function and Site Flashcards

1
Q

IL-1 (Principle Cell Source and Functions)

A

Principle Cell Source: Macrophages, monocytes, endothelial cells, neutrophils

Functions: Fever, Pro-inflammatory

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2
Q

IL-2

A

Principle Cell Source: Activated T cells

Functions: Activate and proliferate T cells/NK, stimulates expression of IL2A on naive T cells

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3
Q

IL-4

A

Principle Cell Source: CD4 (Th2) T cells, mast cells

Functions: B cell to IgE, differentiation of Th2, M2 macrophage differentiation

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4
Q

IL-5

A

Principle Cell Source: CD4 T cells and mast cells

Functions: Activation of eosinophils

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5
Q

IL-6

A

Principle Cell Source: Mø, endothelial cells, T cells, B cells,

Functions: Acute phase proteins, Th17 differentiation, pro-inflammatory, Activate B cells to go into plasma cells

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6
Q

IL-8

A

Principle Cell Source: Macrophages, mast cells

Functions: Chemotactic factor recruits and activates neutrophils

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7
Q

IL-10

A

Principle Cell Source: Macrophages, B cell, Tcell

Functions: Anti-inflammatory released by type 2 Mø to prevent tissue damage, self-tolerance-reduced expression to costimulators

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8
Q

IL-12 (IL-18)

A

Principle Cell Source: Macrophages, DCs

Functions: Th1 differentiation, induce T/NK to produce IFN-G

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9
Q

IL-13

A

Principle Cell Source: Th2 cells

Functions: M2 macrophage activation

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10
Q

IL-15

A

Principle Cell Source: Macrophages, epithelial cells

Functions: Proliferation of NK and T cells, **survival of memory T cells (CD8)

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11
Q

IL-17

A

Principle Cell Source: Th17 cells (CD4)

Functions: simulates acute Neutrophilic inflammation

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12
Q

IL-7

A

Principle Cell Source: ?

Functions: prolif/differentiation of lymphocytes in primary lymphoid tissue, T cell memory factor

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13
Q

TNF-A

A

Principle Cell Source: macrophages, monocytes, T/NK cells, Neutrophils

Functions: integrin/Eselectin, ICAm/Vcam activation, mediator of septic, neutrophil recruitment/activtion, Major pro-inflammatory

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14
Q

TGF-B

A

Principle Cell Source: Macrophages (M2), T regulatory cells

Functions: Wound healing, tissue repaid, inhibition of T cell activation, Th17 differentiation, inhibits mø 1 by cyotokines, induce apoptosis in B cells and CD8 T cells, IgA switching (BAFF produces AID= isotype switching,APRIL), ANTIINFLAMMATORY

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15
Q

IFN-Gamma

A

Principle Cell Source: NK cells, Th1, CTLs

Functions: activate macrophages (m1), IgG isotype switching, supresses IL4/inhibits allergic attack,

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16
Q

IL 22

A

Principle Cell Source: CD4 T cell, NK cells, innate lymphoid cells

Functions: Mantenance of epithelial barrier function

065. My HDM Exam 2 (7 decks)

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