evolution revision Flashcards
when did darwin come up with his theory of evolution and what 2 problems did it solve
1859
- problem of history
- problem of design
problem of history
similarities between animals was confusing - appeared to be variations on a theme
example: cytochrome C - mre similar this protein more similar animals looks
need to think of animals as how closely related
relationship underpinned by time and common ancestor (descent with modification)
problem of design
animals appear well adapted
both adaptation and vestigial (appears no use) could be explained if there were slight changes in each gen, useful ones being more likely to be retained. ones with no harm stay for shits and gigs
define homologies and analogies
H - similarity between organisms due tpo common ancestry (human arm, horse leg etc)
A - similarities due to parallel selective pressures (share a selection pressure, such as adaptations for swimming, do not all share ancestors)
when were mendels peas discovered and what did he discover
1815
discovered principles of inheritence such as segregation and independent assortment
mechanisms for variation
mechanism definition
a system or structure that performs a function
who coined the term genes
wilhelm johannson, who found that theres particles of inheritence passed from parents to offspring to determine phenotypic characteristics
flow of genetics is:
one way
genes affect properties of proteins but proteins don’t affect properties of genes (seen in muscle mass differences father and son, may have a predisposition to build but is not automatic)
complete genome was first discovered in, and what we know about genome
1995 for bateria
first draft of a human completed in 2001
60% gemone + is non coding
exons make up 1%
non coding must be important (pufferfish have more coding regions than us)
psuedogenes
genes that haven’t been translated
polymorphism
variations at a locus between individuals
huntingtons disease
has late onset symptoms, due to allele on chromosome 4, codes for ill-surviving huntingtons protein
types of gene mutations
segmental changes - whole extra chromosomes
transposable element insertions - not always effect, chunks of sequences make copies of self
segmental duplications - important for evo, are extra copies og genes and this may have new mutations for new functions
deleterious genetic mutations often cause mendelian diseases - single gene, follow mendelian laws
how to find genetic basis of phenotypic characteristic (2 studies)
linkage: use big families where some members have/lack characteristic. when 2 genes are on same chromosome there will be some linkage. recomb can disrupt linkage
association study: large groups with/without trait to compare allele frequency
2 functions of genes
a - making more phenotype by mitosis
b - making more genotype via meiosis
modern synthesis
combination of mendels and darwins ideas tpo understand how genetic variatin and natural selection causes change
polymorphism
locus of 2 individuals have different sequences
can have single nucleotide polymorphisms
contribute to diversity
medels peas result from experiment 1 and 2
1: all f1 were yellow, f2 had 3/4 yellow and 1/4 green
2: had 9:3:3:1 ratio of yellow smooth to green wrinkly
this shows independent assortment
neutral theory
the amount of divergence between the DNA of any two populations reflects the time since their common ancestor
this is due to non coding changes and neutral mutations outside of natural selection
functionless molecular change
codominance vs incomplete dominance
C - both phenotypes are expressed such as AB blood
I - phenotype is an intermediate, e.g red and white carnation makes pink. NOT blended - these can still make pink or red, not a new allele
coefficient of relatedness
what proportion of genes are shared
falconars estimate of heritability
what proportion of the variation in the phenotype can be explained by variation in the genotype
in twins, can find gene responsibility by 2 x the correlation for MZ - the correlation of similarity for DZ)
heritability
estimates the degree of variation in a phenotypic trait in a population that is due to genetic variation (0-1)
this is not fixed and can change over population
heritability of walking on 2 legs is low
kallman syndrome
rare genetic disorder, gene identified is KAL-1 on the X chromosome. when this is faulty anosmin is not produced stopping sense of smell, libido, and gonad dev
but this phenotype can be expressed in different ways