Evidence Synthesis

Question 1

what is the GRADE framework?

Answer 1

GRADE is a systematic approach for assessing our confidence in effect estimates from a body of evidence, typically using four categories: high, moderate, low, very low

Question 2

when do you grade down with the GRADE framework?

Answer 2

grade down based on risk of bias, inconsistency, imprecision, and publication bias.

Question 3

when do you grade up with the GRADE framework?

Answer 3

grade up based on large effect, dose response, and confounders

Question 4

how do we define high, moderate, low, and very low in regards to the GRADE framework?

Answer 4

Based on the strength of evidence, high score means further research is very unlikely to change our confidence in the estimate of effect. Moderate means further research will likely have an impact. Low means further research is very likely to have an impact. Very low means we are very uncertain about the estimate