Everything

Question 1

Common Rx’s that are Bases

Answer 1

Local Anesthetics, Amphetamines, PCP

Question 2

To absorb / not eliminate a Acid Drug put it in a _____ environment

Answer 2

Acid : will stay in there HA non ionized form

opposite is true for their elimination

Question 3

To absorbs / not eliminate a Basic Drug put it in a ____ environment

Answer 3

Basic : will stay in there B non ionized form

opposite it true for their elimination

Question 4

Bioability equation (f) =

Answer 4

AreaUnderCurve(PO)/ AreaUnderCurve(IV)

Question 5

Vd (volume of Distrubtion)

Answer 5

Vd= Dose/[plasma]

Question 6

Guneral : CYP inducers

Answer 6

Smoking, Drinking, Barbiturates, Carbamazepine, Phenytoin, Rifampin, St-John’s Wort
“Smoking and Drinking in BARBs CAR RIFs her Phen”

Question 7

General : CYP inhibitors

Answer 7

“COKE” Grape Fruit Juice and PI

Cimetidine, Omeprazole, Ketoconazole, Erythromycin) “macrolides” , GF, Protease inhibitors (ritonavir, atenovir

Question 8

Macrolides are CYP ______

Answer 8

inhibitors Azythromycin

Question 9

Rx’s associated with Rx induced SLE

Answer 9

“HIP” hydralizine > procainamide > isoniazid

Question 10

Rx’s with Zero Order Elimination

Answer 10

“PEA” phenytoin (large dose), ethonal, ASA (large dose)

Question 11

Maintenance Dose =

Answer 11

In = Out MD= Css X Cl X tau (dosing frequency) / f (bio-availabity)

Question 12

half lifes to reach steady state

Answer 12

4-5 “clinical steady state”

Question 13

Clearance GFR relationship

Answer 13

Cl = GFR X Free Fraction 
FreeFraction = 100 - % bound

Question 14

Loading Dose =

Answer 14

Vd X Cp / f

Question 15

half life equation

Answer 15

.7 X Vd/ Cl

Question 16

physiologic antagonism

Answer 16

two agonist with opposing actions

ex. phenylephrin + nitroglycerine

Question 17

chemical antagonism

Answer 17

formation of complex between effector drug and another compound
ex. protamine sulfate + heparin