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PAS Sem 3/4 > Everything > Flashcards

Everything Flashcards

1
Q

What is a p value?

A

Calculated probability of observing an effect size as large or larger than the one observed between the groups, if there was no actual difference between the groups

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2
Q

How is qualitative research carried out?

A 
Interviews
Participant observations
Focus groups
Textual analysis
Action research
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3
Q

What are the key terms in qualitative research?

A

Interpretation
Reality
Truth
Generalisation

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4
Q

What is quantitative research?

A 
Numbers,
Testing a theory
Objectivity
Large sample size
Generalisable narratives
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5
Q

What does quantitative research give you?

A

Clear answers to specific causal questions

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6
Q

What is qualitative research?

A 
Meanings 
Social life
Generating theory
Subjectivity
Small sample size
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7
Q

what does qualitative research leave you with?

A

Applicability within context

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8
Q

What are the cons of qualitative research?

A

Researcher presence and bias
Time consuming
Lack of generalisability
Poor replication and validity

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9
Q

What happens in an observational study?

A

No intervention

Record behaviours, attitudes and symptoms

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10
Q

What is a cohort study?

A

Group of subjects followed over time

Done to find the incidence and investigating potential causes of condition

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11
Q

Are cohort studies prospective or retrospective?

A

Either

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12
Q

What is an experimental study?

A

Researcher controls or introduces factor

Record effects of intervention on outcomes

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13
Q

What is a parallel study?

A

Treatment vs placebo

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14
Q

What is a crossover study?

A

Use the same two groups and do a period when they are the placebo (and then a wash out period) and then a period when they are the active treatment group

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15
Q

What are the phases of a preclinical trial?

A

Preclinical
Clinical (phase 1-3)
Post clinical

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16
Q

What happens in the preclinical phase?

A

Lab tests
Research protocol
Non-human testing

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17
Q

What happens in a phase 1 trial?

A 
Small group (20-100 healthy patients) 
Dose finding
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18
Q

What happens in a phase 2 trial?

A 
Large group (100-1000s) 
Testing of beneficial and undesirable effects
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19
Q

What happens in a phase 3 trial?

A

1000+
Compare with standard therapy
Multiple worldwide locations

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20
Q

What happens in a post clinical trial?

A

Analyse data and write a paper
Follow up
New therapy shown to be safe and effective, approved by medical authorities and continuing testing

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21
Q

What are the different parties in a clinical trial?

A 
Patients
Clinicians
Institutions where trials are held
Research ethics committees or the institutional ethical committee 
Sponsor
Regulatory authorities
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22
Q

What is the step by step of running a clinical trial?

A 
Recruitment
Screening
Informed consent after patient information sheet
Blinding
Protocol visits step by step procedures
Reports of adverse effects 
Store investigates product 
Subject compensation
Electronic data collection 
Study closure
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23
Q

What are the two main cases that have influenced human research protections?

A

Public Health Service syphilis study

Nuremberg (nazi doctors/ww2 scientists)

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24
Q

What does the Nuremberg code state?

A

Need for informed consent
Research should be based on prior animal work
Risks should be justified by anticipated banality
Only qualified scientists must conduct research
Physical and mental suffering should be avoided
No research where death/severe injury is expected

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25
Q

What are the two methods of sampling?

A

Simple random

Convenience

26
Q

What are the pros/cons of simple random sampling?

A

Every member has an equal probability of selection
Representative sample
Not particularly feasible or cost effective though

27
Q

What are the pros/cons of convenience sampling?

A

Participants convenient to access

Sample not particularly representative and you may get selection bias or volunteer bias

28
Q

What are the different types of variables?

A

Categorical

Continuous

29
Q

What is categorical data?

A

Variables with options that don’t have a predictable quantitative relationship between them

30
Q

What is continuous data?

A

Variables measured on a quantitative scale

31
Q

What are the types of bias?

A

Response bias

Assessor bias

32
Q

What is response bias?

A

Difference between response and truth

Particular issue if you are self reporting issues

33
Q

What is assessor bias?

A

Systematic difference between assessor measurement of participant and truth

34
Q

What is the 95% central reference range for numerical data with normal distribution?

A

A measure of the spread of the continuous numerical data

35
Q

What is the unpaired t test used for?

A

Analysing parametric data from independent samples

36
Q

What is parametric data?

A

Data that you’ve assumed normal bias for

37
Q

What is the paired t test used for?

A

Paired parametric data

38
Q

What does the one tailed test do?

A

Only care about significance in one direction and will talk about significantly greater then or significantly less than

39
Q

What does the two tailed test do?

A

Care about significance in both directions and talk about significant difference

40
Q

What does ANOVA stand for?

A

ANalysis Of VAriance

41
Q

What is ANOVA?

A

Standard approach for statistical analysis of studies involving multiple comparison

42
Q

What does ANOVA assume?

A

Data is parametric and unpaired

43
Q

What is a one way ANOVA used for?

A

Studies with 3 or more varying conditions on a single continuous variable

44
Q

What is a two way ANOVA used for?

A

Studies where there is an interaction between two categorical variables on a single categorical variable

45
Q

When are post tests used?

A

If ANVOA is significant

46
Q

What are the types of categorical data analysis?

A

McNemars test
Fishers exact test
Pearsons chi-squared test

47
Q

What is McNemars test appropriate for?

A

Analysing continuous data involving paired data that can be shown in a 2x2 contingency table

48
Q

What is a fishers exact test?

A

Analyses categorical data involving unpaired data that conform to a 2x2 contingency table and a small number of samples

49
Q

What does Pearsons chi-squared test analyse?

A

Categorical data involving unpaired data that cant be measured with fishers test

50
Q

When cant you use Pearsons chi-squared test?

A

If any cell contains zero

51
Q

What is a population?

A

Entire group of people

52
Q

What is a sample?

A

Little group of the population

53
Q

How can you work out they 95% confidence interval for a single mean?

A

Mean +/- 2 standard errors

54
Q

What is the 95% confidence interval a measure of?

A

Precision

55
Q

How do you work out relative risk?

A

Risk in group 1/risk in group 2

56
Q

How do you work out risk difference?

A

Risk in group 1 - risk in group 2

57
Q

What is the four principles approach in ethics?

A

Non-male Vicente
Beneficence
Autonomy
Justice

58
Q

What is civil law?

A

Dealings between private individuals or groups
Rights and duties owed by individuals and groups to each other
Legal action taken by claimants

59
Q

What is criminal law?

A

Matters serious enough to be considered offences against the whole community
Rights, duties and norms important for the whole community
Legal action taken by the crown prosecution service

60
Q

What is statute law?

A

Written law decided by legislature or another government agency
Relatively difficult to change

PAS Sem 3/4 (1 decks)

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