ETC Review Flashcards
ATP from substrate-level phosphorylation
Glycolysis
TCA
TCA Stage 1
Acetyl-CoA production
TCA Stage 2
Acetyl-CoA oxidation
TCA Stage 3
Electron transfer and oxidative phosphorylation
Oxidative Phosphorylation
Mitochondria
Produces most ATP
FADH2 & NADH: electron carriers
-oxidized at ETC
–proton gradient
—synthesize ATP
Mitochondrial Oxidative Phosphorylation
- Respiratory ETC
- ATP synthase uses the proton gradient energy
NADH vs FADH2
Both coenzymes
NADH:
cosubstrate
can move
3 ATP
FADH2:
prosthetic group
can’t move
2 ATP
Complex I
NADH gives electrons to Complex 1, which oxidizes NADH
Transfers electrons to ubiquinone (Q, coenzyme Q)
Protons to ATP synthase
Complex II
Succinate —> fumarate in TCA produces FADH2
Gives electrons to Complex II
Transfers electrons to ubiquinone (Q, coenzyme Q)
Does not produce enough energy to transfer protons
Ubiquinone (Q, Coenzyme Q)
Electron carrier
Transfers electrons to Complex III
Transfers protons from matrix to inter membrane space
Complex III
Transfers electrons to cytochrome c
Protons to ATP synthase
Cytochrome c
Electron carrier
Transfers electrons to Complex IV
Complex IV
Transfers electrons to 1/2 O2
O2 reduced to H2O
Protons to ATP synthase
Complex V
ATP synthase
Where are the five oligomeric assemblies of proteins associated with oxidative phosphorylation found?
Inner mitochondrial membrane