ETC inhibitors

Question 1

Oligomycin

Answer 1

block Fo proton pore, block ATP synthesis, block respiration due to the coupling of ATP synthesis and electron flow

Question 2

Rotenone

Answer 2

Sites w/in ETC block complex I action through specific inhibition of the transfer of electrons from iron-sulfur centers to CoQ

Question 3

antimycin A

Answer 3

block complex III by preventing cyt C from accepting electrons

Question 4

Cyanide and Carbon Monoxide

Answer 4

inhibit cyt oxd (complex iv) by binding to the iron in cytochromes and preventing e- transfer

Question 5

Amytal

Answer 5

Blocks complex I

Question 6

DCCD

Answer 6

block proton entry into ATP synthase

Question 7

CCCP, DNP, Thermogenin

Answer 7

makes membrane permeable to protons and uncouples

Question 8

Valinomycin

Answer 8

membrane becomes permeable to K+ ions

Question 9

Atractyloside

Answer 9

block ADP entry into mitochondria