Essential Tremor

Question 1

What is the most common movement disorder

Answer 1

essential tremor

Question 2

Etiology

Answer 2

aging- more common in older people
family history- 3 loci IDed, but not gene known yet
Environmental: harmane (meat protein), lead exposure

Question 3

Pathophysiology

Answer 3

Two loci:

1. cerebellar degeneration (increase in purkinje cells, neuronal loss in dentate nucleus)
2. Brainstem lewy bodies = accumulation of lewy bodies in locus (ceruleus, substantia nigra)

Question 4

Impairments

Answer 4

1. tremor
2. mobility and balance
3. tandem and midline termor
4. gait
5. effects of age
6. dual task

Question 5

Characteristics of essential tremor

Answer 5

1. rhythmic, oscillatory movements
2. kinetic tremor (during movements); has intentional component, seen in arms and hand
3. postural tremor (arms, head, voice, jaw, tongue)
4. rest tremor (occasionally in absence of bradykinesia or rigidity)