essential pharmacology 1

Question 1

different types of extracellular receptors

Answer 1

1-ionotrophic-affect permeability of ion channels
2-interact with JAK kinases-affect protein synthesis
3-affect enzymatic activity- affect proliferation/differentiation
4-G-protein receptors and second messenger model

Question 2

intracellular receptors-cytosolic

Answer 2

are lipid soluble so can directly diffuse into nucleus and affect transcription of DNA so protein synthesis.
can bind to guanylyl cyclase and activate CGMP as second messenger

Question 3

Camp

Answer 3

1-1st messenger binds to receptor on C.S.M.
2-this triggers sub-unit if G-protein to diffuse across plasma membrane and bind to adenyl cyclase
3-adenyl cyclase cause Camp to be activated
4-this activates protein kinases which phosphorylates proteins

Question 4

phospholipase C

Answer 4

same principle.
Phospholipase C activates IP3 and DAG.
IP3 acts on ER and releases Ca2+ from internal storage
DAG acts on protein kinases.

Question 5

main functions of receptors?

Answer 5

1- enable specificity
2- allow appropriate response- membrane permeability, proliferation and differentiation, metabolism, contractile activity, secretory activity.

Question 6

where does intracellular Ca2+ come from?

Answer 6

1- can come from IP3 release,
2- from outside of cell-ligand-gated channels
3-inhibition of transport out of Ca2+