ESC Guidelines On Cardiac Diseases In Pregnancy Flashcards
Peripartum Cardiomyopathy : Risk factors
°Multiparity °Africa Ethnicity °Smoking ° Diabetes ° Pre-eclampsia ° Malnutrition ° Advanced maternal age ° Teen Pregnancy
Peripartum Cardiomyopathy : causes
° Inflammation
° Angiogenic imbalance
They induce vascular damage.
Peripartum Cardiomyopathy : Biological factors
° Biological active 16 kDa prolactin, fms like tyrosine kinase
May initiate PPCM
Peripartum Cardiomyopathy : presentation
Heart failure 2° to LV systolic dysfunction
May present with arrhythmia and/ cardiac arrest
Peripartum Cardiomyopathy : Diagnosis
Echocardiography: LVEF < 30%
MARKED LV dilatation LVEDD>6.0cm
RV Involvement associated with adverse outcomes
PPCM: prognosis
SA 12,6% affects 1:1000 15-50% morta Germany 2.0% Turkey 24% If EF does not recover > 50% future pregnancy should be discouraged. Recurrence highly possible
Dilated Cardiomyopathy : definition
LV dilatation and dysfunction
Dilated Cardiomyopathy : causes
Viral infection Drugs Ischaemia Idiopathic 50% Hereditary 25-35%
Dilated Cardiomyopathy : stats
Prevalence of idiopathic 1:25000
SA 1:1000
Dilated Cardiomyopathy : prognosis
Predictors of mortality
- NYHA iii/iv
- EF < 20%
- MR
- RV failure
- AF
- Hypotension
Dilated Cardiomyopathy : Prepregnancy counselling and MX
Modification of antifailure RX : stop ACEI, ARBS, AR I, MRAs
Cont Blocker selective B1
Management of HF in pregnancy: acute/subacute HF
Pulmonary Congestion : thiazide + loop diuretic
HPT: Hydralazin, nitrates
Management of HF in pregnancy : haemodynamicaly u stable & cardiogenic shock
Transfer to center with mechanical circulatory support team
Urgent delivery c/s irregardless of gestational age
Avoid Blockers especially in PPCM
Levosimendin ideal ionotrope
Bromocriptine PPCM
Dose 2,5mg daily for 1/52 in uncomplicated cases
2,5mg bd 6/52 EF<25% / cardiogenic shock
Start anticoagulant LMWH/UFH
Management of HF in pregnancy : haemodynamicaly u stable & cardiogenic shock: Devices
Start with wearable ICD 3-6m if no recovery ICD and cardiac resynchronization devices LBBB QRS>130ms
Transplant if mechanical support not possible or no recovery 6-12m
HF in pregnancy : heart Transplant
Avoid pregnancy 1st yearconsi
HF in pregnancy : anticoagulant
Consider if low EF
HF In pregnancy : delivery and breastfeed
CS if haemodynamicaly unstable
No BF if HFrEF or NYHA iii/iv
AHF DURING PREGNANCY flow chart
Recommendation forx of Cardiomyopathy and HF In pregnancy
AHF in pregnancy MX flow chart
Hypertrophic Cardiomyopathy in pregnancy incidence
<1:1000
HOCM in pregnancy mortality rate
0.5% mortality and 29% if symptomatic
HOCM in pregnancy fetal mortality rate
Spontaneous abortion 15%
Therapeutic abortion 5%
Still birth 2%
Premature birth 26%