ESC Guidelines On Cardiac Diseases In Pregnancy Flashcards
Peripartum Cardiomyopathy : Risk factors
°Multiparity °Africa Ethnicity °Smoking ° Diabetes ° Pre-eclampsia ° Malnutrition ° Advanced maternal age ° Teen Pregnancy
Peripartum Cardiomyopathy : causes
° Inflammation
° Angiogenic imbalance
They induce vascular damage.
Peripartum Cardiomyopathy : Biological factors
° Biological active 16 kDa prolactin, fms like tyrosine kinase
May initiate PPCM
Peripartum Cardiomyopathy : presentation
Heart failure 2° to LV systolic dysfunction
May present with arrhythmia and/ cardiac arrest
Peripartum Cardiomyopathy : Diagnosis
Echocardiography: LVEF < 30%
MARKED LV dilatation LVEDD>6.0cm
RV Involvement associated with adverse outcomes
PPCM: prognosis
SA 12,6% affects 1:1000 15-50% morta Germany 2.0% Turkey 24% If EF does not recover > 50% future pregnancy should be discouraged. Recurrence highly possible
Dilated Cardiomyopathy : definition
LV dilatation and dysfunction
Dilated Cardiomyopathy : causes
Viral infection Drugs Ischaemia Idiopathic 50% Hereditary 25-35%
Dilated Cardiomyopathy : stats
Prevalence of idiopathic 1:25000
SA 1:1000
Dilated Cardiomyopathy : prognosis
Predictors of mortality
- NYHA iii/iv
- EF < 20%
- MR
- RV failure
- AF
- Hypotension
Dilated Cardiomyopathy : Prepregnancy counselling and MX
Modification of antifailure RX : stop ACEI, ARBS, AR I, MRAs
Cont Blocker selective B1
Management of HF in pregnancy: acute/subacute HF
Pulmonary Congestion : thiazide + loop diuretic
HPT: Hydralazin, nitrates
Management of HF in pregnancy : haemodynamicaly u stable & cardiogenic shock
Transfer to center with mechanical circulatory support team
Urgent delivery c/s irregardless of gestational age
Avoid Blockers especially in PPCM
Levosimendin ideal ionotrope
Bromocriptine PPCM
Dose 2,5mg daily for 1/52 in uncomplicated cases
2,5mg bd 6/52 EF<25% / cardiogenic shock
Start anticoagulant LMWH/UFH
Management of HF in pregnancy : haemodynamicaly u stable & cardiogenic shock: Devices
Start with wearable ICD 3-6m if no recovery ICD and cardiac resynchronization devices LBBB QRS>130ms
Transplant if mechanical support not possible or no recovery 6-12m
HF in pregnancy : heart Transplant
Avoid pregnancy 1st yearconsi
HF in pregnancy : anticoagulant
Consider if low EF
HF In pregnancy : delivery and breastfeed
CS if haemodynamicaly unstable
No BF if HFrEF or NYHA iii/iv
AHF DURING PREGNANCY flow chart
Recommendation forx of Cardiomyopathy and HF In pregnancy
AHF in pregnancy MX flow chart
Hypertrophic Cardiomyopathy in pregnancy incidence
<1:1000
HOCM in pregnancy mortality rate
0.5% mortality and 29% if symptomatic
HOCM in pregnancy fetal mortality rate
Spontaneous abortion 15%
Therapeutic abortion 5%
Still birth 2%
Premature birth 26%
HOCM in pregnancy mortality risk factors
Symptoms Prepregnancy
Diastolic dysfunction
Severe LV outflow track obstruction
Arrhythmia
HOCM in pregnancy post partum cardiac event risk factors
CARPREG OR ZAHARA> 1
Medication in pregnancy period
HOCM in pregnancy symptoms
HF with pulmonary Congestion
Echo diagnostic
HOCM in pregnancy management frequency of reviews
WHO I reviewed per trimester
WHO III review monthly/ bimonthly
HOCM in pregnancy management AF
Rate control
Supress VA
Verapramil drug of choice when Blocker not tolarated
Cardioversion if unstable persistent AF
HOCM in pregnancy management hypovolaemia
Not well tolarated
HOCM in pregnancy management Anticoagulant
Therapeutic if paroxysmal or persistent arrhythmia
HOCM in pregnancy management Sudden cardiac death
If symptomatic palpitations and/ syncope device insertion recommended