Erythropoietin Flashcards
1
Q
What is EPO?
A
a hormone which circulates at all times and control the production of RBC
2
Q
Where is EPO produced?
A
Majority the kidneys and some in the liver
3
Q
What happens to EPO during hypoxia?
A
Increased EPO release from kidneys stimulating the production of RBC
4
Q
What can cause a release of EPO?
A
Drop in Hb levels
Fall in PO2
Increased tissue demand for O2
5
Q
What is the reticulocyte count?
A
percentage of total RBC
6
Q
What is chronic mountain sickness?
A
disease in which the proportion of blood volume that is occupied by RBC increases (polycythaemia) and there is an abnormally low level of O2 in the blood
7
Q
How does phlebotomy affect RBC and Hb concentration
A
Reduced RBC mass and Hb concentration
8
Q
Treatments for chronic mountain sickness
A
move to lower altitude more physical exercise ace inhibitors dopamingeric antagonists Ventilatory stimulants
