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Hematology > Erythrocyte Development > Flashcards

Erythrocyte Development Flashcards

1
Q

Which pathway results in the production of 23 DPG, which results in oxygen being released from the hemoglobin RBC into the tissues

A

Lumbering Rappaport

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2
Q

What pathways function is to reduce the sulfhydryl groups in the globe and if hemoglobin? And enzyme deficiencyG6PD Makes the RBC unable to reduce the hemoglobin

A

Hexose monophosphate shut

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3
Q

What happen play results in the reduction of iron and hemoglobin that will be able to bond to oxygen?

A

Methemoglobin

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4
Q

Precipitated hemoglobin is known as

A

Heinz bodies

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5
Q

Are Heinz bodies seen with wright’s stain

A

No, only supervital stain

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6
Q

Heinz bodies inclusions results in

A

The removal of the RBCs by the sling as they circulate

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7
Q

Uses glucose to provide energy for the red blood cells landforms ATP

A

Glycolytic pathway EmbdMeyer

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8
Q

Iron is a protein that is transported by the proteins called

A

Transferrin

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9
Q

Measures iron in serum bound to transferrin

A

Serum iron concentration

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10
Q

What is measure of storage fire

A

Plasma ferritin

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11
Q

What is the hormone produced in the kidney

A

Erythropoietin

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12
Q

Increase red blood cell distraction results in the increase of

A

Bilirubin

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13
Q

Bilirubin binds to

A

Albumin unconjugated bilirubin

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14
Q

Bilirubin that binds to albumin is transported to

A

The liver

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15
Q

Bilirubin that binds to albumin that is transported to liver binds to

A

Glucuronic acid and becomes bilirubin diglucuronide conjugated bilirubin

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16
Q

Bilirubin goes down the bile duct to the

A

Intestine which is converted to urobilinogen by intestinal bacteria

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17
Q

Urobilinogen will be increased in the

A

Plasma and urine

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18
Q

What is haptoglobin

A

A protein

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19
Q

A major storage of iron

A

Ferritin

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20
Q

Ferritin binds to

A

Apoferritin the protein component of ferritin molecule without the iron

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21
Q

Nuclear fragment of DNA

A

Howell jolly bodies

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22
Q

Clumps of RNA fine to course deep blue dots evenly destributed

A

Basophils stippling

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23
Q

Threat like rings consist of remnants of mitotic spindle nuclear remnant

A

Cabot ring

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24
Q

Deposits of iron hemosiderin usually in clumps

A

Poppenheimer bodies also called siderocytes

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25
Q

Iron not used in hemoglobin synthesis is normally removed by IV

A

Spleen

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26
Q

What is the word for iron overload

A

Hemochromatosis

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27
Q

What is it called when given many blood transfusions

A

Thalassemia

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28
Q

Iron and bring around nuclear us of immature red blood cells also abnormal

A

Ringed Sideroblast

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29
Q

Increase reticulocytes

A

Polychromasia

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30
Q

When you see large red blood cells you will think

A

They appear macrocytic

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31
Q

What parasite can be acquired from a tick bite

A

Babesia

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32
Q

What parasite is normally seen in South America

A

Malaria

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33
Q

This is seen in G6PD deficiency unstable to hemoglobin and Thalassemia

A

Heinz body

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34
Q

Round retractile inclusions not visible by Wright stain Most are attached to the red blood cell membrane

A

Heinz body

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35
Q

What is it called when you see red sales stick together

A

Rouleaux

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36
Q

What is the formula for MCV

A

HCT X 10/RBC

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37
Q

What is the formula for MCH

A

HB X 10/RBC

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38
Q

What is the formula for MCHC

A

HB X 100/HCT

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39
Q

Membrane is composed of

A

Lipids and proteins

40
Q

If the plasma lipids get out of balance

A

The red blood cell membrane can become deformed

41
Q

What are two proteins in the RBC membrane

A

Actin and spectrin

42
Q

Red blood cells have a net negative charge

A

Zeta potential

43
Q

A protein contain in the RBC that transport oxygen from the lungs to tissue and carbon dioxide from tissue to lungs

A

Hemoglobin

44
Q

How many heme does globin have

A

4

45
Q

What are the six normal polypeptide chains of globin

A

Alpha, beta, Delta, gamma, zeta, and epsilon

46
Q

Variation in size is called

A

Anisocytosis

47
Q

Larger than normal is called

A

Macrocytic

48
Q

Variation in shape means

A

Poikilocytosis

49
Q

Round, lacks central pallor, cell is often smaller

A

Spherocyte

50
Q

Test results affected by spherocytes

A

Increased MCHC

51
Q

Elliptical or oval shape

A

Elliptocyte/ovalocyre

52
Q

Evenly distributed, uniform size,spicules or bumps on surface of RBC seen in all cells

A

Created rbc

53
Q

What is another name for Burr cells

A

Echinocytes

54
Q

Echinocytes/burr cells are seen in what disease

A

Renal

55
Q

Describe the different between created vs burr

A

Created artifact caused by prolonged contact with EDTA more than eight hours
Burr short pointed evenly spaced projections 10 to 30 projections forms when chemical composition of blood is altered such as renal disease

56
Q

Elongated split like area of central power shape like a smiling mouth

A

Stomatocytes

57
Q

Disease associated with the stomatocytes

A

Liver, alcoholism, cirrhosis

58
Q

What is another name for target cells shaped like a hat

A

Codocytes

59
Q

We see hemoglobinopathies in what cell

A

Codocytes/target cells

60
Q

What is another word for thorn cell

A

Acanthrocytes

61
Q

RBC with few irregular space pointed thorn like projections of various lengths and widths

A

Acanthrocyte

62
Q

Red Cell’s sliced By fibrin from clot intravascular coagulation strands DIC

A

Schistocytes

63
Q

What is another name for helmet cells

A

Keratocytes

64
Q

A form of schistocytes with one or more horn like projections

A

Keratocyte

65
Q

Tear drop cell crying in your dacari

A

Dacrocytes

66
Q

What cell is seen in extramedullary hematopoiesis

A

Dacrocytes

67
Q

Rbc that is 7 um in diameter

A

Normocytic

68
Q

Rbc with increased central power

A

Hypochromic

69
Q

Rbc fragment

A

Schistocyte

70
Q

Elongated red cell

A

Ellipotocyte

71
Q

Rbc with central power that takes up about 1/3 of the cell

A

Normochromic

72
Q

Rbc that is larger than normal

A

Macrocytic

73
Q

Tear drop cell

A

Dacrocytes

74
Q

Rbc that is smaller than normal

A

Micro cystic

75
Q

Burr cell

A

Echinocytes

76
Q

Rbc with elongated slit like

A

Stomatocytes

77
Q

Target cell

A

Codocytes

78
Q

Thorn cell

A

Acanthrocyte

79
Q

Sickle cell

A

Drapanocyte

80
Q

basophilic stippling

A

RNA

81
Q

Poppenheimer body

A

Iron

82
Q

Nuclear material membrane mitotic

A

Cabot ring

83
Q

Precipitated hemoglobin

A

Heinz body

84
Q

DNA

A

Howell jolly body

85
Q

Rouleaux formation is seen in what disease

A

Multiple myeloma

86
Q

What protein transport iron in the body

A

Transferrin

87
Q

What is the storage form of iron that cannot be seen

A

Ferrin

88
Q

What is the storage form of precipitated iron that can be seen

A

Hemosiderin

89
Q

What is the stain used to stain iron

A

Prussian blue

90
Q

What does the total iron binding test measure

A

Transferrin

91
Q

When RBCs are removed the heme portion is converted to

A

Bilirubin

92
Q

Bilirubin binds to albumin and is called

A

Unconjugated

93
Q

When RBCs are removed from the heme portion is converted to bilirubin that binds to albumin and is called unconjugated it is carried to the liver where it combines with two molecules of

A

Gluuronic acid

94
Q

When RBCs are removed The heme portion is converted to bilirubin and binds to albumin and it’s called unconjugated it is carried to the liver where it combines with two molecules of glucuronic acid and becomes

A

Conjugated

95
Q

When RBCs are removed the heat portion is converted to bilirubin this product binds to albumin and is called unconjugated. It is carried to the liver where it combines with two molecules of glucuronic acid and becomes conjugated. This product passes down the bile duct and enters the intestines. It is acted on by bacteria in the intestines and is converted to

A

Urobilinogen

96
Q

Which protein is primarily responsible for transport a free hemoglobin which results from intravascular hemolysis to the liver

A

Haptoglobin, and hemopoxin

Hematology (1 decks)

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