Ergot Alkaloids Flashcards
1
Q
ERGOMETRINE
A
MECHANISM
- 5HT AGONIST (strong)
- alpha1 ANTAGONIST
INDICATION
-promote uterine contractions, facilitate labor
SIDE EFFECTS
-‘‘ergotism’’: hallucinations, abortion, feet and arm loss
2
Q
ERGOTAMINE
A
MECHANISM
- 5HT AGONIST (strong)
- alpha1 ANTAGONIST
INDICATION
- post partum hemorrhage: strong VC
- migraine
SIDE EFFECTS
- nausea, vomiting
- high BP
3
Q
DIHYDROERGOTAMINE
A
MECHANISM alpha1»>5HT!!!
-alpha1 selective ANTAGONIST (strong)
INDICATION
nasal spray/injection
-migraine
SIDE EFFECTS
-nausea
4
Q
METHYSERGIDE
A
MECHANISM
-5HT 2B/C antagonist
INDICATION
vasodilation!!!!
-it inhibits the release on NO from the endothelium
(NO has a role in the prephase of headache develoment)
SIDE EFFECTS
- research
- Sumatriptan used instead!!
5
Q
BROMOCRYPTINE
A
MECHANISM
- dopamine agonist
- 5HT agonist
INDICATION
- Parkinson’s disease
- hyperprolactinemia (eg. amenorrhea, infertility and pRL secreting adenoma)
- acromegaly (eg. GH adenoma)
- type 2 diabetes
SIDE EFFECTS
- nausea, vomiting
- orthostatic hypotension
- headaches
6
Q
LSD (LYSERGIC ACID DIETHYLAMIDE)
A
MECHANISM
INDICATION
psychedelic/recreational drug!!!!!
NO medical use
SIDE EFFECTS
- NOT addictive
- adverse psychiatric reactions:anxiety, paranoia, and panic attacks
systemic effects:
- hyperthermia, high HR, BP
- elevated blood sugar
- goose bumps and tremors
- jaw clenching
- hyperhydrosis, saliva and mucus production
