Erectile dysfunction Flashcards
1
Q
Drugs that cause erectile dysfunction
A
- Anti-hypertensive
- Anti-depressants
- Anti-psychotics
- Thiazide diuretics
- Cytotoxic drugs
2
Q
Treatment
A
- First line: phosphodiesterase type 5 inhibitor
- Alprostadil (prostaglandin analogue)
3
Q
Phosphodiesterase type 5 inhibitor: MOA
A
inc blood flow to penis to help achieve an erection
4
Q
Phosphodiesterase type 5 inhibitor: drugs
A
- Sildenafil (1h before sex, delayed onset w food)
- Tadalafil (30 min before sex - LA)
- Vardenafil (25-60min before sex)
- Avanafil (15-30min before sex; delayed onset w food)
5
Q
Phosphodiesterase type 5 inhibitor: indication
A
- Erectile dysfunction
- Sildenafil: Pulmonary arterial hypertension
6
Q
Phosphodiesterase type 5 inhibitor: CI
A
- Hypotension
- Recent stroke
- ACS (MI or unstable angina)
- Vasodilation
- Sex inadvisable
7
Q
Phosphodiesterase type 5 inhibitor: side effect
A
Vasodilation
- Hypotension
- Flushing
- Headache
- Dyspepsia
- Nasal congestion
- Palpitations
- Tachycardia
8
Q
Phosphodiesterase type 5 inhibitor: interaction
A
- Nitrates/Antihypertensive/diuretic → hypotension
- Cytochrome 3A4 Enzyme inhibitor (macrolides, rate limiting CCB, grapefruit juice, fluconazole + ketoconazole → INC plasma levels = toxicity
