ER1 Diseases

Question 1

Conns Disease

Answer 1

Adrenal adenoma

Increased aldosterone, Decreased Renin

Hypertension

Question 2

Cushings Syndrome

Answer 2

Adrenal tumor

Increased ACTH –> Increased Cortisol

Moon face, buffalo hump, skin striations, reduced inflammatory response, early pubic hair

Question 3

Addisons Disease

Answer 3

Adrenal gland

Decreased ACTH –> decreased Cortisol

Bronze pigmentation of skin and gum sign, weight loss, abdominal pain, salt craving

Question 4

Pheochromocytoma

Answer 4

Adrenal medulla tumor

Increased NE and E

Hypertension, panic attacks, headache, sweating, tachycardia

Question 5

Graves disease

Answer 5

antibody mimics TSH –> Increased TH

Bulging eyes, tremors, weight loss, diarrhea

Question 6

Goiter

Answer 6

Iodine deficiency –> increased TSH

enlarged thyroid gland

Question 7

Carcinoid syndrome

Answer 7

GIT (APUD cells) secrete high Serotonin

Cutaneous flushing, diarrhea, increased 5-HIAA in urine

Question 8

Laron disease

Answer 8

GH receptors deficiency –> decreased GH

dwarfism in children, adults no effect

Question 9

Graves disease

Answer 9

hyperthyroidism caused by stimulatory abs for TSH-R

TSH = neg feed back thus overall:
decreased TRH
decreased TSH
increased TH

Question 10

Hashimoto

Answer 10

hypothyroidism caused by inhibitory abs for TSH-R

TSH = neg feedback thus overall:
increased TRH
increased TSH
decreased TH

fatigue, weight gain, puffiness in face, constipation, slow reflexes and Amenorrhea (increased TRH leads to increased prolactin)

Question 11

Cushing disease

Answer 11

same as Cushing syndrome

but

virilization in females and early puberty in males