Equipment on the Line

Question 1

Poucher

Answer 1

See picture (of Brovana in pouch).

Question 2

Bottler

Answer 2

Generally for capsules to be bottled.

Question 3

Desiccant

Answer 3

Provide moisture control within a bottle.

Question 4

Conveyor

Answer 4

Conveyor belt

Question 5

Outfeed Conveyor

Answer 5

Can avoid an operator reaching into a machine.

Question 6

Collection Bin

Answer 6

Can avoid an operator reaching into a machine.

Question 7

Label Roll Changeover

Answer 7

Should be avoided. Operator changes printing stock on the printer. Introduces potential errors and waste of time & printing stock.

Question 8

Primary packaging examples

Answer 8

Vials, Cartons, Bottles, Syringe, IV ___, Blister Packs, Patches, Respules, Nasal Spray, Spray through throat, Tape (sub-lingual),

Question 9

Blister packs

Answer 9

are commonly used as unit-dose packaging for pharmaceutical tablets, capsules or lozenges. … A series of blister cavities is sometimes called a blister card or blister strip as well as blister pack.

The primary component of a blister pack is a cavity or pocket made from a formable web, usually a thermoformed plastic. This usually has a backing of paperboard or a lidding seal of aluminum foil or plastic. A blister that folds onto itself is often called a clamshell.

Blister packs are useful for protecting products against external factors, such as humidity and contamination for extended periods of time. Opaque blisters also protect light-sensitive products against UV rays.

Question 10

Thermoforming

Answer 10

Thermoforming is a manufacturing process where a plastic sheet is heated to a pliable forming temperature, formed to a specific shape in a mold, and trimmed to create a usable product.

Question 11

Thermoforming

Answer 11

Thermoforming is a manufacturing process where a plastic sheet is heated to a pliable forming temperature, formed to a specific shape in a mold, and trimmed to create a usable product.

Question 12

Buccal administration

Answer 12

Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.

Question 13

Sublingual (abbreviated SL)

Answer 13

Sublingual (abbreviated SL), from the Latin for “under the tongue”, refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue which is predominantly a mucous gland that produces a thick mucinous fluid and lubricates the oral cavity which allows for swallowing, initiating digestion, buffering pH, and dental hygiene.[1]

Question 14

Gene or Cell Therapy

Answer 14

(Note: This seems to be a specialty.)

Question 15

Lyophilization as a Stabilization Tool

Answer 15

Lyophilization is particularly beneficial to parenteral drug developers, as a stable powder for injection can be easily packaged and transferred as a finished drug product. Lyophilization can also be employed to produce stable intermediates in drug product development and manufacturing. Hydrolytically unstable formulation components such as PLGA microparticles or fragile APIs may be lyophilized to create a longer shelf life and accommodate multi-step manufacturing processes. For example, APIs that undergo high energy media milling (AKA nanomilling) may be lyophilized prior to incorporation into an oral solid dosage form.

Question 16

Parenteral drug administration

Answer 16

Parenteral drug administration means any non-oral means of administration, but is generally interpreted as relating to injecting directly into the body, bypassing the skin and mucous membranes.