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Biol 475- Neurobiology > Equilibrium and resting potential > Flashcards

Equilibrium and resting potential Flashcards

1
Q

does the rate of diffusion change as we increase the number of particle?

A

No, it is about the same rate

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1
Q

the greater difference in concentration the more __________ _______ needed to meet equilibrium

A

electrical force

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2
Q

what does Nersnt equation measure?

A

electrical potential at electrochemical equilibrium

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3
Q

originally which ions is more likely to be inside cell?

A

K+

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4
Q

originally which ions is more likely to be outside cell?

A

Na+, Cl-

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5
Q

which helps ion to pass through membrane?

A

channels

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6
Q

why does ions move back and forth but not staying after they move to one side?

A

concentration force might cause them to move to one side, but the equal number of ions is attracted back by electrical force

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7
Q

what is the estimate electric potential of K (EK+) ?

A

~-85mV

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8
Q

what is the estimate electric potential of Na (ENa+) ?

A

~+55mV

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9
Q

what is the estimate electric potential of Cl (ECl-) ?

A

~ -66mV

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10
Q

what happen when Driving force is large and Permeability is large?

A

ions can move normally through membrane

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11
Q

what happen when Driving force is small and Permeability is large?

A

ions can still move through membrane due to large permeability & regardless of small driving force

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12
Q

what happen when Driving force is large and Permeability is small?

A

large driving force favor the movement of ions across membrane but small P restrict amount pass through
-> not many ions can pass through

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13
Q

action potential?

A

quick electrical signal in nerve cells travel along axon which allow message to send to body

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14
Q

3 characteristics of action potential

A
  • travel over long distance
  • high fidelity
  • rapid transmission
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15
Q
A
16
Q

3 states of action potential

A
  • depolarization
  • repolarization
  • hyperpolarization
17
Q

membrane potential becomes more positive compared to the resting membrane potential

A

depolarization

18
Q

membrane potential that was previously depolarized is brought back to the resting potential

A

repolarization

19
Q

membrane potential becomes more negative compared to the resting membrane potential

A

hyperpolarization

20
Q

which channels that axon has?

A

only potassium channel

21
Q

how does the gradient distribute in K+ channel?

A

more polarization near the source than downstream

22
Q

activation gate of Na+ channel open at?

A

depolarization

23
Q

inactivation gate of Na+ channel open at?

A

repolarization

24
Q

activation gate of Na+ channel closed at?

A

repolarization

25
Q

inactivation gate of Na+ channel closed at?

A

depolarization

26
Q

what is self-limited of Na channel?

A

automatic open & close with the influence of membrane potential

27
Q

which gate of Na+ channel is slower?

A

inactivation channel

28
Q

what factor determine the open/close of the voltage-gated channel?

A

by membrane potential of the cell

29
Q

how to calculate driving force on ion?

A

driving force = membrane potential - equillibrium potential of ion

30
Q

how to calculate current of ion?

A

current (I) = driving force x permeability

31
Q

activation gate of K+ channel open at?

A

depolarization

32
Q

activation gate of Na+ channel close at?

A

repolarization

33
Q

which voltage gated channel is faster?

A

Na+ gated channel is faster

34
Q

which period where it is impossible to generate another action potential?

A

absolute refractory period

35
Q

which period that is still possible to generate another AP because the voltage-gated has recover from inactivation?

A

relative refractory period

36
Q

what is action potential propagation?

A

transmission of an action potential along the length of axon

37
Q

what happen when AP trigger at one place?

A

trigger cascade events= depolarize in adjacent regions

38
Q

when does relative refraction period occur?

A

follow after absolute refraction period

Biol 475- Neurobiology (4 decks)

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