equations for phamacokinetics

Question 1

What is the equation for bioavailability (F) using AUCoral and AUCiv?

Answer 1

​F = (AUCoral × Doseiv) / (AUCiv × Doseoral)

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Question 2

What is the simplified equation for bioavailability (F) when doses are equal?

Answer 2

F = AUCoral / AUCiv

Question 3

What is the equation for volume of distribution (V) using the initial plasma concentration (C₀)?

Answer 3

V = Dose / C₀

Question 4

What is the equation for volume of distribution (V) using the y-intercept from a concentration-time curve?

Answer 4

V = Dose / y-intercept

Question 5

What is the equation for clearance (CL) using dose and AUC?

Answer 5

CL = Dose / AUCiv

Question 6

What is the equation for the elimination rate constant (k) using clearance and volume of distribution?

Answer 6

k = CL / V

Question 7

What is the equation for half-life (t₁/₂) using the elimination rate constant (k)?

Answer 7

t₁/₂ = 0.693 / k

Question 8

What is the equation for steady-state concentration (Css) during continuous infusion?

Answer 8

Css = Rate of Infusion / Clearance

Question 9

What is the equation for steady-state concentration (Css) using dose, bioavailability, dose interval, and clearance?

Answer 9

Css = (Dose × F) / (Dose Interval × CL)

Question 10

What is the equation for plasma concentration after distribution?

Answer 10

Plasma Concentration = (Dose × F) / V

Question 11

What is the equation for Area Under the Curve (AUC) using dose, bioavailability, and clearance?

Answer 11

AUC = (Dose × F) / CL