Eponyms/Pathognomonics - AP

Question 1

Schaumann bodies

Answer 1

Concentric lamellated calcifications seen in macrophages. Typically associated with Sarcoidosis.

Question 2

Mikulicz cells

Answer 2

Macrophages seen in Rhinsoscleroma which contain the gram-negative Klebsiella organisms.

Question 3

Flexner-Wintersteiner rosettes

Answer 3

Rosette structures seen clasically in retinoblastoma.

Question 4

Schuller-Duval bodies

Answer 4

Glomeruloid structures seen classically in yolk sac tumors

Question 5

Pautrier microabscesses

Answer 5

Intradermal/junctional collections of MF lymphocytes.

Question 6

Auspitz sign

Answer 6

Pinpoint and easy bleeding seen in scales of Dermatitis Herpetiformis

Question 7

Masson bodies

Answer 7

Airspace collections of connective tissue seen in organizing pneumonia

Question 8

Medlar bodies

Answer 8

“Copper pennies” seen in chromoblastomycoses (eg, fonsecaceae)

Question 9

Henderson-Patterson bodies

Answer 9

AKA Molluscum bodies, seen in molluscum contagiosum

Question 10

Civatte bodies

Answer 10

Necrotic keratinocytes seen in many dermatoses but most classically Lichen Planus

Question 11

Hirano bodies

Answer 11

Intraneuronal eosinophilic actin aggregates that are truly not specific for any disorder.

Question 12

Mallory Denk Bodies

Answer 12

Intrahepatocytic collections of ubiquitin, E2, and intermediate filaments seen clasically in alcoholic hepatitis but actually many conditions.

Question 13

Bunina bodies

Answer 13

Intraneuronal granular inclusions seen in ALS; not actually specific, nor staining for TDP-43 (of which inclusions are normally also seen).

Question 14

Lewy bodies

Answer 14

Alpha-synuclein positive inclusions seen in Parkinson’s and Lewy Body Dementia.

Question 15

Negri bodies

Answer 15

Intraneuronal cytoplasmic inclusions seen in Rabies infection

Question 16

Asteroid body

Answer 16

MIcroskeletal elements seen in multinucleated giant cells of classically sarcoidosis

Question 17

Spider cell

Answer 17

Spindly vacuolated and abnormal rhabdomyocytes seen in cardiac rhabdomyomas of tuberous sclerosis

Question 18

Call-Exner bodies

Answer 18

Rosette-like structures seen in Granulosa cell tumor (adult moreso than juvenile)

Question 19

Rosenthal fibers

Answer 19

Thick eosinophilic fibers seen rather nonspecifically but classically in pilocytic astrocytoma

Question 20

Michaelis-Gutmann bodies

Answer 20

Targetoid histiocyte inclusions seen in Malakoplakia

Question 21

Aschoff bodies

Answer 21

Inflammatory nodules of myocardium seen in Rheumatic Fever