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Oral Path 2 Prelims > Epithelial Odontogenic Tumor > Flashcards

Epithelial Odontogenic Tumor Flashcards

1
Q

Benign but locally infiltrative Odontogenic neoplasm

A

Ameloblastoma

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2
Q

Location of ameloblastoma

A

Mandibular molar-ramus and maxillary molar

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3
Q

Age where ameloblastoma occurs in life

A

4th or 5th decade of life

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4
Q

It is asymptpmatic unless there is nerve impingement or the lesion is very big

Range from simple swelling in gingiva or cystic lesion

A

Ameloblastoma

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5
Q

What radiographic lesion is this

Molar ramus area
Monolocular or multilocular
Associated with an IMPACTED TOOTH
Expansion of jaw and resorption of roots of room
Separation of roots or teeth

A

Ameloblastoma

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6
Q

Treatment of ameloblastoma

A

Resection

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7
Q

Most commonly seen histological subtype of ameloblastoma

A

Follicular ameloblastoma

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8
Q

A subtype of ameloblastoma in which the islands and sheets are interconnected together in cords or strands of odontogenic epithelium

A

Plexiform ameloblastoma

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9
Q

A subtype of ameloblastoma in which it is related to the skin

Epithelial keratin pearls are present

And the eithelium is squamous type

A

Acanthomatous “squamous metaplasia”

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10
Q

A subtype of ameloblastoma that its cells have granules (pink dots_ which can be seen in higher magnification

It also contain high lysosomal production

Exhibits prominent cytoplasmic granularity and swelling

A

Granular cell ameloblastoma

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11
Q

A subtype of amelloblastoma it which the hyperchromatic nuclei is more dense than the follicular type

It also contains stellate-reticular like cells

A

Basal cell ameloblastoma

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12
Q

A subtype of ameloblastoma it which it has a dense collagenous stroma or sometimes spindle shaped.

Cords of odontogenic epithelium are present

There are sharp areas

A

Desmoplastic ammeloblastoma

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13
Q

What are the biologic subtypes of ameloblastoma

A
  1. Conventional
  2. Peripheral / extraosseous
  3. Unicystic - fluid filled sac
  4. Metastasizing
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14
Q

Intraosseous / within bone
Single cyst cavity
Associated with unerupted or impacted teeth
Bony expansion / root resorption

A

Unicystic ameloblastoma

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15
Q

Histologic feature

Cuboidal palisading cells
Thin, nonkeratinized epithelium
Spongiosis
Eithelial invaginations
Subepithelial hyalinization
Spongiotic epithelial lining “parachute cells”

A

Unicystic ameloblastoma

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16
Q

Treatment for unicystic ameloblastoma

A

Excision

17
Q

Soft tissue counterpart of intraosseus

A

Peripheral / extraosseous

18
Q

Where does peripheral ameloblastoma arises from its overlying epithelium

A

Rests of serres

19
Q

Columnar paslisading reverse polarity

What biological subtype of ameloblastoma

A

Peripheral / extraosseous

20
Q

Treatment for peripheral ameloblasotma

A

Local Excision

21
Q

Primary tumor location of metastasizing ameloblastoma

A

Mandible

22
Q

An ameloblastoma that can transfer from one location to another

It metastasize despite benign histopathological appearance

A

Metastasizing ameloblastoma

23
Q

Risk factor of metastasizing ameloblastoma

A
  1. Large size / may enlarge fast
  2. Protracted clinical course
  3. Multiple recurrences at the primary site
  4. Inadequate removal
24
Q

A gene that is associated with ameloblastoma

A

BRAF gene

25
Q

A drug that is promising for the treatment of metastaszing ameloblastoma

A

MAPK inhibitory drugs
BRAF inhibitors

26
Q

Benign epithelial ofontogenic tumor characterized by amyloid, which my calcify

A

Calcifying epithelial odontogenic tumor ( pindborg tumor )

27
Q

Other name for calcifying epithelial odontogenic tumor

A

Pindborg tumor

28
Q

Clinical features

AsymptomTic
Slow growing localized expansion of the jaw and tooth mobility
Occurs in tooth bearing areas of the jaw
60% mandible, 85% arise centrally

A

Calcifying epithelial odontogenic tumor

29
Q

Histologic features:

Sheets, islands, and cords of polyhedral cells with distinct borders

Amyloid

Prominent intercellular bridges

Nuclear and cellular pleomorphism

A

Calcifying epithelial odontogenic tumor

30
Q

Calcified deposits seen as concentric circles

A

Liesgang rings
- calcifying epithelial odontogenic tumor

31
Q

Treatment for ceot

A

Enucleation to resection

32
Q

Benign encapsulated epithelial
Engolfs crown of the tooth
Have rosette or duct like structures
Has an indolent behavior

A

Adenomatoic odontogenic tumor

33
Q

Have rosette or duct like structure

A

Adenomatoic odontogenic tumor

34
Q

Gene mutation of adenomatoid odontogenic tumor

A

KRAS gene (70% of cases)

35
Q

More common in female

Seen in 2/3 of maxilla

A

Adenomatoid odontogenic tumor

36
Q

Benign, slow growing, squamoud differentiation

Asymptomatic swelling - minority are associated with pain, tenderness, mobility of teeth or bone expansion

A

Squamous odontogenic tumor

37
Q

Radiographic feature of squamous odontogenic tumor

A

Triangular or semicircular unilocular radiolucency with well-defined borders along one or more tooth roots

38
Q

Histologic feature

Squamous metaplasia
-flat cuboidal cells at the periphery
Center is flat
Collagenous stroma

A

Squamous odontogenic tumor

39
Q

Treatment of squamous odontogenic tumor

A

Curretage or excision

(Minimal risk of occurence)

Oral Path 2 Prelims (1 decks)

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