Epilepsy & PD Pharm

Question 1

First line tx for focal seizures

Answer 1

Lamotrigine, Levetiracetam, Topiramate

Question 2

First line tx for focal seizures in elderly

Answer 2

gabapentin, Lamotrigine

Question 3

First line tx for absence seizure

Answer 3

divalproex, lamotrigine, ethosuximide

Question 4

first line tx for myoclonic

Answer 4

divalproex, levetiracetam

Question 5

first line tx for tonic - clonic

Answer 5

Lamotrigine, levetiracetam, topiramide

Question 6

which seizure drugs have a BBW for liver toxicity?

Answer 6

Divalproex, Valproic Acid, Felbamate

Question 7

Which seizure medications have BBW for Rash?

Answer 7

Carbamezapine, Lamotrigine

Question 8

AE of Phenytoin?

Answer 8

Gingival Hyperplasia, Osteoporosis, Ataxia / Cerebellar toxicitiy

Question 9

What seizures should you NOT use Carbamazepine?

Answer 9

Myoclonic, Absence

Question 10

Phentyoin MOA and Ind:

Answer 10

MOA: Na channel inhibition
Ind: GTCS, PS, SE

Question 11

Carbamezapine MOA and Ind:

Answer 11

MOA: Na channel inhibition
Ind: CPS, GTCS

Question 12

Carbamezapine AE:

Answer 12

HEPATOTOXICITY, RASH, dizziness, diplopia, SIADH, osteopenia, AA

Question 13

genetic CI for Carbamezapine?

Answer 13

HLAB1502

Question 14

Ethosuximide MOA, Ind, AE

Answer 14

MOA: inhibits T-Calcium Channel
Ind: Absence
CI: Nightmares, Sedation

Question 15

Valproic Acid MOA, Ind, AE

Answer 15

MOA: increase GABA, blocks Na-channels
Ind: broad
AE: sedation, Weight Gain, hair loss, plt aggregation, pedal edema, Parkinson sx (tremor)

Question 16

Felbamate MOA, Ind, AE

Answer 16

MOA: Na chanel blocker, NMDA receptor
AE: wt loss, AA, HA, insomnia, hepatotoxicity
Ind: GTCS, PS, refractory (LGS)

Question 17

Gabapentin Ind, AE

Answer 17

Ind: 2nd line / adjunct PS; good for elderly, few drug ixn.
AE: pedal edema, irritability

Question 18

Lamotrigine MOA, AE, Ixn, Ind

Answer 18

MOA: inhibit glutamate and Na channels
AE: dizziness, HA, RASH, visual changes
Ixn: decreases OCP, Taper slow, Preg Cat C
Ind: partial, GTCS

Question 19

Topiramate

Answer 19

MOA: Na, GABA, Glutamate, Carbonic Anhydrase
Ind: PS, GTCS. mono / adj.
AE: oligohydrosis, renal stones, concentration, word-finding, sedation, glaucoma

Question 20

Highly protein bound drugs?

Answer 20

Phenytoin, Valproic Acid, Diazepam

Question 21

Wt Gain Causing

Answer 21

Valproic Acid, Divalproex, Carbamezapine, Gapapentin

Question 22

Wt Loss causing

Answer 22

Topiramate, Felbamate, Zonisamide

Question 23

With these you need Vit D and Ca Supplements,

and Folic Acid metabolism is higher

Answer 23

Phenytoin, Phenobarbitol, Carbamezapine, Valproic Acid