Epilepsy I Takeda Flashcards

1
Q

Inhibition synapse

A

Increases Cl- current inward and neurotransmitter is GABA

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2
Q

Excitation synapse

A

Increases Na, Ca currents inward and neurotransmitter is glutamate

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3
Q

Absence seizures

A

Brief staring spells with sudden onset and resolution

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4
Q

Myoclonic seizures

A

Brief, shock-like jerk of a muscle or group of muscles

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5
Q

Atonic seizures

A

Sudden loss of postural tone

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6
Q

Tonic seizures

A

Symmetric, tonic muscle contraction of extremities with tonic flexion of waist and neck

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7
Q

Carbamazepine enzymes induced

A

CYP3A4, CYP2C8, CYP1A2

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8
Q

Lamotrigine enzymed induced

A

UGT1A4

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9
Q

Phenytoin enzymes induced

A

CYP2C9, CYP2C19

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10
Q

Phenobarbital enzymes induced

A

CYP3A4

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11
Q

Lamotrigine and carbamazepine cautions

A

SJS and rash with HLA-B*1502

Caution with asian decent

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12
Q

Labs for monitoring

A

CBC, chemistry, LFTs, ammonia levels, vitamin D

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13
Q

Absence seizures treatment

A

Ethosuximide

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14
Q

Generalized seizure treatment

A
Lamotrigine
Keppra
Rufinamide
Topiramate
Valproic acid
Zonisamide
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15
Q

Focal seizure treatment

A
Cabramazepine
Gabapentin/Pregabalin
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenytoin
Topiramate
Valproic acid
Zonisamide
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16
Q

Pregnancy other recommendations

A

Folic acid before and after pregnancy.

Avoid Valproic acid

17
Q

Menstrual cycle epilepsy treatment

A

Progesterone po or vaginally
Topiramate, zonisamide, acetazolamide
Clobazam