Epilepsy I Takeda Flashcards
Inhibition synapse
Increases Cl- current inward and neurotransmitter is GABA
Excitation synapse
Increases Na, Ca currents inward and neurotransmitter is glutamate
Absence seizures
Brief staring spells with sudden onset and resolution
Myoclonic seizures
Brief, shock-like jerk of a muscle or group of muscles
Atonic seizures
Sudden loss of postural tone
Tonic seizures
Symmetric, tonic muscle contraction of extremities with tonic flexion of waist and neck
Carbamazepine enzymes induced
CYP3A4, CYP2C8, CYP1A2
Lamotrigine enzymed induced
UGT1A4
Phenytoin enzymes induced
CYP2C9, CYP2C19
Phenobarbital enzymes induced
CYP3A4
Lamotrigine and carbamazepine cautions
SJS and rash with HLA-B*1502
Caution with asian decent
Labs for monitoring
CBC, chemistry, LFTs, ammonia levels, vitamin D
Absence seizures treatment
Ethosuximide
Generalized seizure treatment
Lamotrigine Keppra Rufinamide Topiramate Valproic acid Zonisamide
Focal seizure treatment
Cabramazepine Gabapentin/Pregabalin Lamotrigine Levetiracetam Oxcarbazepine Phenytoin Topiramate Valproic acid Zonisamide