Epilepsy Drugs Flashcards
DOC for absence seizures?
Ethosuximide (3Hz spike)
Ethosuximide ADRs
“EFGHIJ- Ethosuximide causes Fatigue, GI distress, HA, Itching, steven-Johnson Sx”
1st line for acute status epilepticus?
Benzos (Diazepam, Lorazepam, Midazolam)- incr GABA(A) action
1st line in neonates, incr GABA(A) action
Phenobarbital
for Tx of tonic-clonic, simple and complex seizures,
1st line for Px of status epilepticus,
Phenytoin, Fosphenytoin
Phenytoin, Fosphenytoin: ADRs?!***
Nystagmus, Gingival hyperplasia, Neuropathy, Hirsutism, Megaloblastic anemia, DRESS Sx, steven-Johnson Sx, diplopia, ataxia
1st line for simple and complex seizures and for Trigeminal neuralgia, blocks Na+ channels
Carbamazepine
lots of ADRs! FA pg 500
1st line Tx for tonic-clonic and 2nd line for absence seizures..
also for other seizures, bipolar disorder, migraine Px
Valproic acid
Valproic acid: ADRs
rare but fatal HEPATOTOXICITY (check LFTs),
GI distress, neural tube defects (CI in preg), tremor, weight gain
increases Na+ channel inactivation, incr GABA conc by inhibiting GABA transaminase?
Valproic acid
incr GABA conc by irreversibly inhibiting GABA transaminase, for simple/cmplx seizures?
Vigabatrin
incr GABA action and blocks Na+ channels,
ADRs: kidney stones!!, sedation, mental dulling?
Topiramate
Blocks voltage-gated Na+ channels; Must be titrated slowly to avoid steven-Johnson Sx
Lamotrigine
for simple/cmplx seizures, Incr GABA by inhibiting reuptake
Tiagabine
what 4 epilepsy drugs predispose to steven-johnson Sx?
Carbamazepine, phenytoin, ethosuximide, and lamotrigine
