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Neurology > Epilepsy drugs > Flashcards

Epilepsy drugs Flashcards

1
Q

DOC for tonic-clonic seizures

A

Phenytoin, Carbamazepine, Valproate

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2
Q

DOC for absence seizures

A

Ethosuximide

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3
Q

DOC for prophylaxis of tonic-clonic seizures

A

Phenytoin

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4
Q

DOC for acute status epilepticus

A

Benzos (diazepam or lorazepam)

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5
Q

Phenytoin

A

MOA: blocks Na channels
SE: Gingival hyperplasia, hirsutism, megaloblastic anemia, nystagmus, ataxia, teratogenic (fetal hydantoin syndrome), P450 induction, zero-order kinetics

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6
Q

Carbamazepine

A

MOA: blocks Na channels
SE: Diplopia, ataxia, blood dyscrasias (agranulocytosis, aplastic anemia), teratogen, liver toxicity, P450 inducer, SIADH, SJ syndrome

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7
Q

DOC for trigeminal neuralgia

A

Carbamazepine

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8
Q

Lamotrigine

A

MOA: blocks V-gated Na channels
SE: SJ syndrome

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9
Q

Gabapentine

A

MOA: GABA analogue; inhibits HVA Ca channels
SE: sedation, ataxia

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10
Q

Topiramate

A

MOA: blocks Na channels, potentiates GABA
SE: sedation, ataxia, anomia, renal stones, weight loss

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11
Q

Phenobarbital

A

MOA: increases duration of GABAa receptor opening
SE: sedation, tolerance, dependance, P450 inducer

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12
Q

Valproic acid

A

MOA: blocks Na channels, inhibits GABA transaminase
SE: GI distress, hepatotoxic (rare, but fatal), teratogen (neural tube defects)
CI: preggos

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13
Q

Ethosuximide

A

MOA: blocks T-type Ca channels (thalamus)

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14
Q

Benzodiazepines

A

MOA: Increase frequency of GABAa receptor opening

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15
Q

DOC for seizures of eclampsia

A

MgSO4

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16
Q

Tiagabine

A

MOA: inhibits GABA re-uptake

17
Q

Vigabatrin

A

MOA: irreversibly inhibits GABA transaminase
SE: sedation, fields defects, psychosis

18
Q

Levetiracetam

A

MOA: unknown (may modulate GABA and glutamate release)
SE: Neuropsychiatric effects, sedation

19
Q

Felbamate

A

SE: aplastic anemia, hepatotoxicity

Neurology (9 decks)

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