Epilepsy Flashcards

1
Q

what questions must you ask to asses an episode of collapse?

A
Patient account
History preceding events-stimulus, context
Context/timing
Posture
History of event itself
Warning symptoms-feel lightheaded
Level of awareness/recollection
Afterwards
First recollection
Seizure markers- prolonged disorientation, tongue biting, incontinence, muscle pains
Witness account (ALWAYS TRY AND GET THIS)
How were they before?
Context
Description of episode
Eyes open or closed
Description of abnormal movements
Pallor, alteration in breathing pattern, pulses
Duration of LOC
Time to recovery
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2
Q

what are the 3 categories of syncope, and what are each of their causes?

A

Reflex (neuro-cardiogenic):
Taking blood/medical situations
Cough, Micturation

Orthostatic:
Dehydration, medication related (anti-hypertensive)
Endocrine, autonomic nervous system

Cardiogenic:
Arrhythmia, aortic stenosis

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3
Q

What assessments must be completed if a patient has had syncope?

A
Examination
Heart sounds, pulse
Postural BPs
Must have ECG
Look for heart block
QT ratio
May need 24hr ECG
May need to see cardiology if recurrent (5 day recordings, reveal devices)
Consider Tilt table
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4
Q

what is the patients account for a cariogenic syncope>

A
History preceding events
On exertion
History of event itself
Chest pain, palpitations, SOB
Afterwards
Chest pain, palpitations, SOB
Came round fairly quickly
Recovery may be longer
	Clammy/sweaty
Witness account (ALWAYS TRY AND GET THIS)
Description of episode
Suddenly went floppy
Looked grey/ashen white
Seemed to stop breathing
Unable to feel a pulse
There may have been a few brief jerks
Variable duration of LOC
Rapid recovery
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5
Q

how to assess a patient with cariogenic syncope?

A
Family history important
Examination
Heart sounds, pulse
Must have ECG
Look for heart block
QT ratio
Refer to cardiology urgently/admission for telemetry
May need 24hr ECG/ECHO/prolonged monitoring
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6
Q

what is epilepsy?

A

Epilepsy is the tendency to recurrent seizures

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7
Q

what can cause a provoked seizure?

A
Alcohol withdrawal
Drug withdrawal
Within few days after a head injury
Within 24hrs of stroke
Within 24hrs of neurosurgery
With severe electrolyte disturbance
Eclampsia
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8
Q

what are the 2 classifications of seizure?

A

generalised seizures and focal seizures

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9
Q

what are the subtypes in generalised seizures?

A
Absence seizures
Generalised tonic-clonic seizures
Myoclonic seizures
Juvenile myoclonic epilepsy
Atonic seizures
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10
Q

what are the subtypes in focal seizures?

A

Simple partial seizures

Complex partial seizures

Secondary generalised

Or by localisation of onset (temporal lobe, frontal etc

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11
Q

symptoms on primary generalised

A
No warning
< 25 years
May have history of absences and myoclonic jerks as well as GTCS e.g in juvenile myoclonic epilepsy
Generalised abnormality on EEG
May have family history
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12
Q

symptoms of focal/partial>

A

May get an “aura”
Any age – cause can be any focal brain abnormality
Simple partial and complex partial seizures can become secondarily generalised
Focal abnormality on EEG
MRI may show cause

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13
Q

Generalised Tonic clonic seizure- history and patient account?

A

Patient account
History preceding events
Unpredictable, tend to cluster
PMH- complications at birth, Feb conv, trauma, menigitis, brain injuries
History of event itself
May have vague warning
Irritability before them
Afterwards
Lateral (severe) Tongue biting, incontinence
First recollection in ambulance or hospital
Muscle pain

Witness account (ALWAYS TRY AND GET THIS)
Groaning sound
Tonic (rigid phase)
Then generalised jerking in all four limbs
Eyes open
Staring/ roll upwards
Foaming at the mouth
Jerking for a few minutes and then groggy for 15-30mins

May be agitated afterwards
May have a cluster of episodes, stopping and starting

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14
Q

who can get absence seizures? can they be provoked? what are the notable features?

A

Often in children (unaware of them)
May be provoked by hyperventillation/ Photic stimulation (light through trees while in car)
Sudden arrest of activity for a few seconds
Brief staring
May have eye-lid fluttering
Re-start what they were doing

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15
Q

juvenile cyclonic epilepsy?

A
Adolescence/early adulthood
Provoked by alcohol, sleep deprivation
Can have absence and GTC seizures
Will often have early morning myoclonus
Drop things in the mornings
Brief jerks in limbs
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16
Q

patient account of complex partial seizures? witness account?

A
Patient account
History preceding events
Rising feeling in stomach, Funny smell/taste
De ja vu (familiar experience)
History of event itself
No recollection
Afterwards
Disorientated for a spell
witness:Sudden arrest in activity
Staring blankly into space
Automatisms
Lip smacking
Repetitive picking at clothes

May be disorientated for a spell afterwards

17
Q

how to do a clinical assessment of a seizure?

A

Refer to first seizure clinic
Do an ECG, routine bloods (Glc)
A+E will often arrange a CT

From Neurology clinic
May arrange an MRI for focal lesion
May arrange EEG (Usually in <40yrs)
Discuss Anti-epileptic drugs
Refer to Epilepsy nurse (post diagnostic information)
Discuss driving (inform DVLA)
18
Q

incidence and prevalence of Epilepsy?

A

Incidence: 50 - 120 per 100 000 per year
“J-shaped” curve
3 - 5% of the population will experience at least one seizure in their lifetime
Prevalence: 5 – 8 per 1000 (Aberdeen 0.9%)
22% of patients with LD have Epilepsy
There are over 300 000 people in the UK with active epilepsy

19
Q

investigations to do for a seizure?

A

EEG for primary generalised epilepsies including hyperventilation and photic stimulation: sometimes sleep deprivation
MRI for patients under age 50 with possible focal onset seizures: CT usually adequate to exclude serious causes over this age
Video-telemetry if uncertainty about diagnosis

20
Q

what are the factors influencing seizure risk?

A

Missed medications (most common)
Sleep disturbance, fatigue
Hormonal changes
Drug/alcohol use, drug interactions
Stress/Anxiety
Photosensitivity in a small group of patients
Other rarer reflex epilepsies (patterns, noise)

21
Q

First line of treatment for epilepsy?

acutely?

A

Sodium Valproate, Lamotrigine, Levetiracetam for primary generalised epilepsies
Lamotrigine, Carbamazepine, Levetiracetam for focal and secondary generalised seizures
Ethosuximide for absence seizures

Acutely
Lorazepam, midazolam (diazepam) first line:
Valproate or phenytoin second line for status epilepticus

22
Q

second line of treatment of generalised epilepsy?

A

Topiramate
Zonisamide
Clobazam

23
Q

second line of treatment for partial seizure?

A
Sodium valproate
-Topiramate
-Gabapentin
-Pregabilin
-Zonisamide
-Lacosamide
-Perampanel
Long acting Benzodiazepines (Clobazam)
Vigabatrin
24
Q

side affect of therapy?

A

Phenytoin – Arrythmia, hepatitis, medication interactions
Sodium Valproate - tremor, weight gain, ataxia, nausea, drowsiness, hepatitis
Try and avoid in women of childbearing age
Carbamazepine - ataxia, drowsiness, nystagmus, blurred vision, low serum sodium levels, skin rash.
Lamotrigine –skin rash, difficulty sleeping
Levetiracetam – irritability, depression

25
Q

what are the driving regulations?

A

After a single seizure, a patient may drive a car after 6 months if their investigations are normal and they have had no further events
They may drive an HGV or PSV after 5 years if their investigations are normal, they have no further events and they are not on anti-epileptic medication
Patients with epilepsy can drive a car once they have been seizure free for a year or have only had seizures arising from sleep for a year.
If they have ever had a day time seizure but then the pattern becomes noctural, this must be established for three years before they can drive
They can only hold a HGV or PSV licence if they have been seizure free for 10 years and are not on anti-epileptic medication

26
Q

what is status epileptics?

what is the mortality and demographics?

A

Prolonged or recurrent tonic-clonic seizures persisting for more than 30 minutes with no recovery period between seizures
9 000 - 14 000 cases /year in the U.K.
usually occurs in patients with no previous history of epilepsy (stroke, tumour, alcohol)
Mortality : 5-10%
Be wary of non-convulsive status epilepticus
Prolonged unresponsiveness following a seizure

27
Q

first line of treatment for status epileptics?

A

Midazolam: 10mg by buccal or intra-nasal route, repeated after 10mins if necessary
Lorazepam: 0.07mg/kg, usually 4mg bolus repeated once after 10 mins
Diazepam: 10 - 20mg iv or rectally, repeated after 15 mins if necessary

28
Q

second line of treatment for Status epileptics?

A

Second line
Phenytoin - slow infusion of 15 – 18mg/kg at 50mg/min
Valproate – 20 -30mg/kg iv at 40mg/min
? Leviteracetam 30mg/KG
Third line
Anaesthesia usually with propofol or thiopentone

29
Q

what is the outcome for status epileptics?

A

Mortality greatest in very young and very old (29% of those < 1 year)
Mortality is highest secondary to strokes, encephalitis, mass lesions and trauma
90% of deaths are a result of the underlying cause
Avoid secondary damage
neurological problems reported in 24% of children following episode of status.

30
Q

what is the patient account for non epileptic attack/ pseudo seizure?

A

History preceding events
Events may occur at times of stress or while at rest
Will often give lots of detail of others reaction and little of events themselves
History of event itself
May recall what people said during episode
May be prolonged episode, waxing and waining
May describe dissociation
Afterwards
Others reactions

31
Q

pseudo seizure witness account?

A

Witness account (ALWAYS TRY AND GET THIS)
Description
May recognise stress as a trigger (even if patient doesn’t)
May report signs of patient retaining awareness
Tracking eye movements, still some verbalisation during episodes
Movements not typical of seizures
Pelvic thrusting
Asynchronous movements, tremor
Episodes waxing and waining
Ideally we try and capture a typical episode on EEG
-Important to make diagnosis to avoid iatrogenic harm