Epilepsy Flashcards

1
Q

What is epilepsy?

A

A recurrent tendency to spontaneous intermittent abnormal electrical activity in part (or all) of the brain manifesting as seizures

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2
Q

What is a prodrome?

A
  • A change in mood or habit lasting hours or days that may precede a seizure
  • It is not part of the seizure
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3
Q

What is the aura?

A
  • A feeling that a seizure is about to come on. The patient is aware of this preceding the seizure
  • It is part of the seizure
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4
Q

What does post-ictal mean?

A

Afetr the seizure

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5
Q

What symptoms are associated with post-ictal patients?

A
  • Headache
  • Confusion
  • Myalgia
  • Sore tounge
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6
Q

What are the causes of epilepsy?

A
  • 2/3 are idiopathic (often familial)
  • Structural → Cortical scarring, developmental, space occupying leision, stroke, hippocampal scleriosis, vascular formations, vascular malformations.
  • Other→ Tuberous sclerosis, SLE, Sarcoidosis
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7
Q

What is the major differential diagnosis to a seizure that needs to be ruled out?

A

Syncopal attack → Reflex anoxic convulsions give a seizure like appearance but with no post-ictal symptoms.

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8
Q

What is a partial seizure?

A
  • Has a focal onset
  • Each focal area has symptoms associated with it.
  • Temporal, frontal, Parietal, Occipital
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9
Q

What are the associated symptoms of a temporal lobe focal seizure?

A

Post-ictal confusion is common

  • Automatism → Complex motor phenomena with impaired awareness and little recollection afterwards
  • Abdominal rising sensation or pain
  • Dysphasia
  • Memory phenomena → De javue or jamais vue (everything seems strange)
  • Hippocampal involvment→ Emotional involvment (eg. sudden terror)
  • Uncal involvment → Hallusination of smell or taste
  • Delusional behaviour
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10
Q

What are the associated symptoms of a frontal lobe focal seizure?

A

characterised by rapid recovery and little post-ictal symptoms

  • Motor features → Posturing, versive movements of the head and eyes, peddeling of the legs
  • Jacksonian march → spreading focal motor seizure with retained awareness
  • Motor arrest
  • Subtle speach disturbance
  • Aphasia
  • Post-ictal todds palsy → transient neurological defecit (paresis)
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11
Q

What are the associated symptoms of a occipital lobe focal seizure?

A

• Visual phenomena → spots, lines, flashes

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12
Q

What are the associated symptoms of a parietal lobe focal seizure?

A
  • Sensory disturbance → Tingling, numbness, pain

* Motor disturbance

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13
Q

What are the 2 main types of epileptic seizure?

A

Generalised and partial

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14
Q

What are the 3 types of partial seizure?

A
  • Simple partial → Aweareness is unimpaired. No post-ictal symptoms
  • Complex partial → Awareness is impaired. Commonly start in temporal lobe.
  • Partial seizure with secondary generalisation → Focal start to seizure (simple or complex) that then becomes general
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15
Q

What are the 5 types of generalised seizures?

A
  • Absence seizure → Stops mid sentence and then continuos where they left off. Presents in childhood
  • Tonic clonic seizure → Loss of consciouness with (tonic) limb stiffness followed by (clonic) jerks. post-ictal confusion and drowsiness
  • Myoclonic seizures → Sudden jerk of limb face or trunk → Violent
  • Atonic seizures Sudden loss of muscle tone causing a fall. No LOC
  • Infantile spasms → Commonly assoc. with tuberous sclerosis
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16
Q

What drugs should be advised after 1 fit?

A

NONE! psych! unless risk of reccurence is high → Structural brain leision etc.

17
Q

What drugs are prescribed for generalised tonic-clonic seizures?

A
  • 1st line → Sodium valporate and lamotrogine
  • 2nd line → Carbemazepine or topiramate
  • 3rd line → levetiracem, oxcarbazapine, clobazam
18
Q

What drugs are prescribed for absence seizures?

A

• sodium valporate, Lamotrigine, ethosuxamide

19
Q

What drugs are prescribed for tonic, atonic and myotionic seizures?

A

Avoid Carbemazepine or oxcarbazapine!!!

  • 1st line → Sodium valporate and lamotrogine
  • 2nd line → topiramate
  • 3rd line → levetiracem, clobazam
20
Q

What drugs are prescribed for partial and secondary generalised seizures?

A

1st line → Carbemazipine

2nd line → Sodium valporate, lamotrigine

21
Q

What is a non-epileptic attack disorder associated with?

A
  • Traumatic childhood experience
  • biting tip of tounge
  • Essentially faking it.
22
Q

What is the leading cause of generalised idiopathic epilepsy thought to be?

A

Febrile convulsions causing scarring of the hippocampus

23
Q

What is status epilepticus?

A
  • A seizure lasting more than 30 mins or repeat seizures without regaining consciousness.
  • Aim to terminate seizures in <20 mins
24
Q

What is a differential diagnosis for a pateint with status epilepticus if they are pregnant?

A

Eclampsia

25
Q

What is the 1st step in treating status epilepticus?

A

Basic life support!

26
Q

What is the 1st treatment oriented step in treating status epilepticus?

A
  • IV lorazepam

* if IV is not possible then buccal medazolam

27
Q

What is the 2nd treatment oriented step in treating status epilepticus if fits continue?

A

• IV phenytoin

28
Q

What is the 3rd treatment oriented step in treating status epilepticus if fits continue?

A

• IV Diazapam

29
Q

What is the 4th treatment oriented step in treating status epilepticus if fits continue?

A

• IV dexamethasone

30
Q

What is the 5th treatment oriented step in treating status epilepticus if fits continue?

A

• General anaethesia