Epigastric Pain Flashcards
What are the 5 most likely differentials for a 60 year old man with acute epigastric pain?
Acute pancreatitis Gastritis/duodenitis Peptic ulcer disease (perforated) Biliary colic Acute cholecystitis
What other symptoms are important to ask about in patients with epigastric pain?
Nausea/Vomiting?
Fever?
Dyspepsia?
Changes in their stool?
Cough?
In the absence of abdominal symptoms other than abdominal pain, cough and/or productive sputum raises the likelihood of what?
Basal pneumonia
What is of particular relevance in past medical history in a patient with epigastric pain?
Biliary disease
- Prone to recurrence
Peptic ulcer disease
- Perforated ulcer until proven otherwise
GORD
- High rates of recurrence
Vascular disease
- Mesenteric ischaemia
Which drugs are associated with acute pancreatitis?
Sodium valproate
Steroids
Thiazides
Azathioprine
What is Cullen’s or Grey Turner’s sign?
Discoloration due to extravasated blood in the retroperitoneum, around the umbilicus, flank respectively
These may be seen in acute haemorrhagic pancreatitis but are, non-specific, and late signs
What are the signs of bowel obstruction?
A distended abdomen
Absent or tinkling bowel sounds
What does severe, generalised tenderness and guarding suggest?
Peritonitis
What are the causes of pancreatitis?
I GET SMASHED
Idiopathic (10-20%) Gall stones Ethanol Trauma Steroids Mumps/HIV/Coxsackie infection Autoimmune Scorpion bite Hyperlipidaemia ERCP Drugs
What are the most common causes of acute pancreatitis?
Gallstones and ethanol
What is the scoring mechanism used to assess the severity and prognosis of pancreatitis?
Glasgow scale
What are the components of the Glasgow scale?
How many criteria are required to be positive for the patient to be considered to have severe pancreatitis
PANCREAS
PaO2: 55
Neutrophilia: >15x10^9 cells/L (WCC)
Calcium: 16mM
Enzyme: LDH >600 U/L or AST >200 U/L
Albumin: 10mM (non diabetics)
How is H. pylori infection detected?
13C-urea breath test
Anti-Helicobacter blood serology
H pylori-positive endoscopic biopsy
What are the NICE guidelines for the treatment of H. pylori?
7-day, twice daily course of full dose PPI
Metronidazole 400mg and clarithromycin 250mg
OR Amoxicillin 1g and 500mg clarithromycin
What are the signs of duodenal perforation on CXR/abdo Xrays?
Air under the diaphragm
Supine abdominal Xray shows the ‘football sign’ (a large bubble of air, in the abdomen)