Epigastric Pain Flashcards

1
Q

What are the 5 most likely differentials for a 60 year old man with acute epigastric pain?

A
Acute pancreatitis
Gastritis/duodenitis
Peptic ulcer disease (perforated)
Biliary colic
Acute cholecystitis
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2
Q

What other symptoms are important to ask about in patients with epigastric pain?

A

Nausea/Vomiting?

Fever?

Dyspepsia?

Changes in their stool?

Cough?

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3
Q

In the absence of abdominal symptoms other than abdominal pain, cough and/or productive sputum raises the likelihood of what?

A

Basal pneumonia

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4
Q

What is of particular relevance in past medical history in a patient with epigastric pain?

A

Biliary disease
- Prone to recurrence

Peptic ulcer disease
- Perforated ulcer until proven otherwise

GORD
- High rates of recurrence

Vascular disease
- Mesenteric ischaemia

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5
Q

Which drugs are associated with acute pancreatitis?

A

Sodium valproate
Steroids
Thiazides
Azathioprine

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6
Q

What is Cullen’s or Grey Turner’s sign?

A

Discoloration due to extravasated blood in the retroperitoneum, around the umbilicus, flank respectively

These may be seen in acute haemorrhagic pancreatitis but are, non-specific, and late signs

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7
Q

What are the signs of bowel obstruction?

A

A distended abdomen

Absent or tinkling bowel sounds

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8
Q

What does severe, generalised tenderness and guarding suggest?

A

Peritonitis

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9
Q

What are the causes of pancreatitis?

A

I GET SMASHED

Idiopathic (10-20%)
Gall stones
Ethanol
Trauma
Steroids
Mumps/HIV/Coxsackie infection
Autoimmune
Scorpion bite
Hyperlipidaemia
ERCP
Drugs
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10
Q

What are the most common causes of acute pancreatitis?

A

Gallstones and ethanol

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11
Q

What is the scoring mechanism used to assess the severity and prognosis of pancreatitis?

A

Glasgow scale

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12
Q

What are the components of the Glasgow scale?

How many criteria are required to be positive for the patient to be considered to have severe pancreatitis

A

PANCREAS

PaO2: 55

Neutrophilia: >15x10^9 cells/L (WCC)

Calcium: 16mM

Enzyme: LDH >600 U/L or AST >200 U/L

Albumin: 10mM (non diabetics)

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13
Q

How is H. pylori infection detected?

A

13C-urea breath test

Anti-Helicobacter blood serology

H pylori-positive endoscopic biopsy

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14
Q

What are the NICE guidelines for the treatment of H. pylori?

A

7-day, twice daily course of full dose PPI

Metronidazole 400mg and clarithromycin 250mg

OR Amoxicillin 1g and 500mg clarithromycin

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15
Q

What are the signs of duodenal perforation on CXR/abdo Xrays?

A

Air under the diaphragm

Supine abdominal Xray shows the ‘football sign’ (a large bubble of air, in the abdomen)

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16
Q

What are the indications for endoscopic investigation if dyspepsia?

A

Persistent vomiting

Chronic GI bleeding

Weight loss

Progressive dysphagia

Iron-deficiency anaemia

Epigastric mass

Suspicious barium meal

Age >55 with unexplained and persistent, recent-onset dyspepsia

17
Q

How does the breath test for H. pylori work?

A

The patient is given a drink of 14C or 13C-unlabelled urea

This is metabolised by the bacteria, if present, into CO2

Breath test is conducted 15 minutes later, and will detect the labelled CO2 if H. pylori

18
Q

What are the complications of peptic ulcers?

A

Haemorrhage

Perforation

Penetration

Scarring

Malignancy

19
Q

How can the complications of pancreatitis be organised?

A

Local (pancreatic and other) or Systemic

20
Q

What are the local complications of pancreatitis?

A

Pancreatic

  • Necrosis of the pancreas
  • Abscess formation
  • Pseudocyst (accumulation of fluid in the lesser peritoneal sac)

Other

  • Paralytic ileus
  • Duodenal stress ulceration
  • Fistula formation to colon
  • Obstructive jaundice
21
Q

What are the systemic complications of pancreatitis?

A

Sepsis

Shock

Acute renal failure

Respiratory compromise

Disseminated intravascular coagulation

Hypocalcaemia or hyperglycaemia

Pancreatitic encephalopathy

22
Q

What is the role of stool elastase in chronic pancreatitis management? Why?

A

Very good marker of pancreatic function

  • Only synthesised in the pancreas
  • Stable in transit through the GI tract, thus there is a direct correlation between elastase in the stool and in pancreatic fluid
23
Q

What are Cushing’s and Curling’s ulcers?

A

Both are peptic ulcers with different aetiology

Cushing’s ulcers arise after brain injury

Curling’s ulcers occur after burns

24
Q

How can the causes of elevated serum amylase be categorised?

A

Pancreatic

Other intra-abdominal pathology

Decreased amylase clearance

Miscellaneous conditions

25
Q

What are the pancreatic causes of an increased serum amylase?

A

Pancreatitis

Pancreatic trauma

Pancreatic carcinoma

26
Q

What are the other intra-abdominal pathologies that result in an increased serum amylase level?

A

Perforated peptic ulcer

Acute appendicitis

Acute cholecystitis

Ectopic pregnancy

Pelvic inflammatory disease

Mesenteric ischaemia

Leaking AAA

27
Q

What can cause an increased serum amylase through decreased amylase clearance?

A

Renal failure

Macroamylasaemia (amylase is bound to immunoglobin and cannot be renally excreted)

28
Q

What are the miscellaneous causes of a raised serum amylase level?

A

Diabetic ketoacidosis

Head injury