Epidemiology Final Exam Flashcards
Incidence Proportion
of new cases of disease during specified time interval / Population at risk at start of time interval
Synonyms for Incidence Proportion
1) Attack Rate. 2) Risk 3) Probability of developing disease 4) Cumulative incidence
Secondary Attack Rate
of new cases among contacts / (# of people at risk-primary cases)
Incidence Rate
of new cases of disease during specified time interval/ summed person-years of observation or average population during time interval
Point prevalence
of current cases (new and preexisting) at a specified point in time / Population at the same specified point in time
Period Prevalence
of current cases (new and preexisting) over a specified period of time/Average or mid-interval population
Crude Death Rate (Crude Mortality Rate)
Total # of deaths during a given time interval/Mid-interval population
Cause-Specific Mortality Rate
of deaths assigned to a specific cause during a given time interval/Mid-interval population
Proportionate Mortality
of deaths assigned to a specific cause during a given time interval/Total # of deaths from all causes during the same time interval
Death-to-case Ratio
of deaths assigned to a specific cause during a given time interval/# of new cases of same disease reported during the same time interval
Neonatal mortality rate
of deaths among children< 28 days of age during a given time interval/# of live births during the same time interval
Postneonatal mortality rate
of deaths among children 28-364 days of age during a given time interval/# of live births during the same time interval
Infant mortality rate
of deaths among children< 1 year of age during a given time interval/# of live births during the same time interval
Maternal mortality rate
of deaths assigned to pregnancy-related causes during a given time interval/Number of live births during the same time interval
Age-Specific Mortality Rate
of deaths of people in a particular age group/# of people present in the age group
Sex-Specific Mortality Rate
of deaths males OR females/ # of males OR females
Race-Specific Mortality Rate
of deaths among people in particular race category/# of people in particular race category
Case Fatality Rate
of cause specific deaths among incident cases/ total # of incident cases
infectivity
of people infected/ # of people exposed
Pathogenicity
of people who develop clinically apparent disease/ # of people infected
Virulence
of people who die/ # of people who develop clinically apparent disease
Attributable Risk % (AKA attributable risk reduction ARR)
(# case in exposed/total # exposed) - (#cases unexposed/total # unexposed)
Control Group Rate/Risk (CGR)
of events in control group/total # of control participants
Experimental Group Rate/Risk (EGR)
of events in experimental group/total # of experimental participants
Attributable Risk Reduction
Control Group Rate (CGR) - Experimental Group Rate (EGR)
Relative Risk
EGR/CGR
Relative Risk Reduction (RRR)
1) (CGR-EGR)/CGR
2) 1-(EGR/CGR)
3) 1-RR
*Note: all 3 formulas should give you the same result
Epidemiology
The study of the distribution and determinants of health-related states or events in specified populations and the application of this study to control of health problems
Etiology
The cause of a disease
Primary Prevention
Action taken to prevent the development of a disease in people who do not have the disease Examples: Vaccines, healthy behaviors, etc.
Secondary Prevention
Identifying people in whom a disease process has already begun but who have not yet developed clinical signs or symptoms of the disease (preclinical phase) Examples: Cancer screening, mammograms, etc.
Tertiary Prevention
Preventing complications in those who have already developed signs and symptoms of an illness and have been diagnosed (those in the clinical phase of illness) Examples: Cancer treatment, physical therapy, etc.
Direct Transmission
Disease is transmitted from person to person by direct contact. Examples: STIs
Indirect Transmission
Disease is transmitted from person to person by a common vehicle like contaminated air or water or a vector. Examples: yellow fever (mosquitos), Lyme Disease (ticks), etc.
Disease
any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury. A diseased organism commonly exhibits signs or symptoms indicative of its abnormal state. There is subclinical or non-clinical (change from normal structure or function) vs. clinical disease (change from normal structure or function expressed via signs/symptoms)
Clinical Disease
Characterized by signs and symptoms
Nonclinical (inapparent) disease
Signs and symptoms have not developed. Includes preclinical, subclinical, persistent, and latent disease.
Preclinical disease
Disease is not clinically apparent but is destined to progress to clinical disease
Subclinical disease
Disease is not clinically apparent and is not destined to become clinically apparent. Diagnosed by serologic response or culture of the organism
Persistent (chronic) disease
Disease or infection that can last for many years or even life
Latent disease
Infection with no active multiplication of the agent, only the genetic message is present, not the viable organism
Carrier
Person who harbors the organism but is not infected as measured by serologic studies or shows no evidence of clinical illness
Endemic
The habitual presence of a disease within a given geographic area
Epidemic
The occurrence in a community or region of a group of illnesses of similar nature, clearly in excess of normal expectancy and derived from a common or a propagated source
Pandemic
A worldwide epidemic
Common-vehicle exposure
Cases arise from the same exposure; Example: food poisoning outbreak from bad chicken at a buffet
Herd immunity
The resistance of a group of people to an attack by a disease to which a large proportion of the members of the group are immune
Incubation period
The interval from infection to the time of onset of clinical illness. Often measured as the time from exposure until the onset of clinical disease as it is difficult to determine the exact time of infection.
Epidemic curve
A graph used to characterized the two primary types of outbreaks (common source and propagated). The y-axis is the number of cases and the x-axis is the date of onset each case patient. Note not all epidemics are common source or propagated- for example with some zoonotic or vector borne diseases.
Primary case
A person who acquires the disease from a specific exposure
Secondary case
A person who acquires the disease from exposure to a primary case
Epidemiologic surveillance
The ongoing systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice closely integrated with the timely dissemination of these data to those who need to know
Passive surveillance
Surveillance in which available data on reportable disease are used, or in which disease reporting is mandated or requested by the government or the local health authority, with the responsibility for the reporting often falling on the health care provider or district health officer. Provider initiated; less resource intensive. Also known as ‘passive reporting’
Active surveillance
A system in which staff are specifically contact providers or others to carry out a surveillance program. Often more accurate than passive. Health-department initiated; more resource intensive
Rates
Tell how fast the disease is occurring in the population
Proportions
Tell what fraction of the population is affected
Cumulative incidence proportion
Incidence calculated using a period of time during which all of the individuals in the population are considered to be at risk for the outcome.
Person-time
The sum of the units of time that each individual was at risk and was observed. Often expressed in person-months or person-years.
Prevalence
The number of affected persons present in the population at a specific time divided by the number of persons in the population at that time. What proportion of the population is affected by the disease at that time?
Case fatality
What percentage of people who have a certain disease die within a certain time after the disease was diagnosed?
Direct age adjustment
A standard population is used in order to eliminate the effects of any differences in age between two or more populations being compared. Most commonly used method.
Indirect age adjustment
Used when numbers of deaths for each age-specific stratum are not available or in an occupationally exposed population.
Cohort effect
Changes seen are attributable to the characteristics of the particular ‘cohort’ under study, not the variable being studied.
Evidence-Based Medicine (EBM)
Conscientiously working with patients to help them resolve (sometimes) or cope with (often) problems related to their physical, mental, and social health
Hierarchies of evidence
A system of classifying and organizing types of evidence, typically for questions of treatment and prevention. Clinicians should look for the evidence from the highest position in the hierarchy
Evidence
Any empirical observation, whether systematically collected or not.
Evidentialism
A theory of knowledge that holds that the justification or reason of a belief is determined by the quality of the believer’s evidence for the belief
GRADE (Grading of Recommendations Assessment, development, and Evaluation)
System of rating the quality of evidence and strength of recommendations that is explicit, comprehensive, and increasingly adopted by guideline organizations. Four levels (very low-high).
Secondary evidence-based journals
A secondary journal does not publish original research but rather includes synopses of published research studies that meet prespecified criteria of both clinical relevance and methodologic quality
Background questions
These clinical questions are about physiology, pathology, epidemiology, and general management and are often asked by clinicians in training. The answers to background questions are often best found in textbooks or narrative review articles.
Foreground questions
These clinical questions are more commonly asked by seasoned clinicians. They are questions asked when browsing the literature (e.g., what important new information should I know to optimally treat my patients?) or when problem solving (e.g., defining specific questions raised in caring for patients and then consulting the literature to resolve these problems)
PICO framework
Patient, Intervention, Comparison, Outcome. A method for answering clinical questions
Therapy (foreground clinical questions)
Determining the effect of interventions on patient-important outcomes (symptoms, function, morbidity, mortality, and costs)
Harm (foreground clinical questions)
Ascertaining the effects of potentially harmful agents (including therapies from the first type of question) on patient-important outcomes
Differential diagnosis (foreground clinical questions)
In patients with a particular clinical presentation, establishing the frequency of the underlying disorders
Diagnosis (foreground clinical questions)
Establishing the power of a test to differentiate between those with and without a target condition or disease
Prognosis (foreground clinical questions)
Estimating a patient’s future course
Randomized trial/ Randomized Clinical Trial
An experiment in which individuals are randomly allocated to receive or not receive an experimental diagnostic, preventive, therapeutic, or palliative procedure and then followed up to determine the effect of the intervention
Control groups
A group that does not receive the experimental intervention. In many studies, the control group receives either usual care or a placebo