Ephedrine Flashcards
1
Q
What is the pharmacologic category/class of ephedrine?
A
- synthetic non-catecholamine sympathomimetic
- direct & indirect acting alpha/beta agonist
2
Q
What is the mechanism of action of ephedrine?
A
- Direct: stimulation of both alpha and beta receptors
- Indirect: causes release of endogenous norepinephrine
Similar effects as epi, but less potent and longer lasting
3
Q
What is the adult bolus dose range of ephedrine for hypotension during anesthesia?
A
- 5-10 mg, repeat as needed for max cumulative dose of 50 mg
Some sources say single dose range is up to 25 mg
4
Q
What is the pediatric bolus dose range of ephedrine for hypotension during anesthesia?
A
- 0.1-0.3 mg/kg, repeat as needed for max cumulative dose of 50 mg
5
Q
What is the onset of action for ephedrine?
6
Q
What is the duration of action for ephedrine?
A
- 15-90 minutes
Epi is only ~5 minutes
7
Q
What organ(s) are responsible for ephedrine’s clearance (metabolism/elimination)?
A
- Metabolism: Liver (P450)
- Elimination: Kidneys
8
Q
True or false:
Ephedrine is the preferred sympathomimetic for administration to parturients experiencing hypotension related to anesthesia
A
- False - it is more likely to cause fetal acidosis than phenylephrine
