EPH Flashcards
List 3 categories of food hazards and given an example of each
List 3 categories of food hazards and given an example of each
Chemical:
Lead
Arsenic
Mercury
Aflatoxin
Dioxin
Cyanide (cassava)
Allergens (peanut)
Acid (kombucha)
Pesticides
Sanitizer residue
Biological (95%):
Bacteria - C. jejuni, E. coli O157:H7, S. flexneri, S. sonnei, L. monocytogenes
Biotoxins - Paralytic shellfish poisoning toxin, botulinum toxin,
Viruses - norovirus, hepatitis A
Fungi - aspergillus
Parasites - giardia
Physical:
Glass
Metal
Plastic
Wood
Animal bones, feathers, shells
List and describe 3 federal acts related to food safety
Food and Drugs Act - establishes standards for food labeling for foods that are imported or transported between provinces,packaging, composition, advertising, additives, and pesticides
Safe Food for Canadians Act - streamlines existing food legislation (Fish Inspection Act, Meat Inspection Act, Canadian Agricultural Products Act) to safeguard against food tampering, strengthens regulations for imported foods, improves food traceability, prohibits the sale of recalled food,
Canadian Food Inspection Agency Act - established the CFIA, and provides powers to recall food
List and describe 3 surveillance systems for monitoring food borne illness in Canada.
List and describe 3 surveillance systems for monitoring food borne illness in Canada.
FoodNet - monitors foodborne illness and pathogens from 4 sentinel sites, collecting data from human, retail food, farm, and water sources
PulseNet - monitors and connects genetic data on organisms that cause foodborne illness across Canada, via NML
NESP - National Enteric Surveillance Program. Weekly reporting for detection of emerging and priority enteric disease trends. Integrates national and international data on lab-confirmed foodborne illness
List 5 principles that should be included in a food safety plan
List 5 principles that should be included in a food safety plan
HACCP:
Hazard analysis
Identifying critical control points
Establishing critical limits for each critical control point
Establishing monitoring procedures for critical control points
Establishing corrective actions
Record keeping
Establishing verification procedures
List and describe the roles of 4 stakeholders involved in an inter-provincial food-borne illness outbreak investigation
List and describe the roles of 4 stakeholders involved in an inter-provincial food-borne illness outbreak investigation
CFIA – inspection of food, livestock, feed, plants, seeds; food safety investigations (tracing), recalls
Health Canada – health risk assessments to the CFIA and P/T, public communication
PHAC – coordinates the outbreak response
NML – reference services for strain identification and characterization, surveillance, disseminate information via PulseNet Canada and the National Enteric Surveillance Program (NSEP)
CNPHI – facilitate communication, early notification for potential outbreaks
P/T governments and associated agencies – food safety investigations, foodborne illness investigations
FNIHB – food safety investigations, foodborne illness investigations on reserve
Define “cluster”
higher than expected incidence of a disease for a defined group of people, in an area for a given time period
Steps in a cluster investigation (4)
Initial contact
Assessment - significantly more cancer than expected? Standardized incidence ratio (observed/expected)
Feasibility study - hypothesis, likelihood,
Etiologic investigation - draw epidemiologic association between the hazard and cancer incidence
List 5 limitations and challenges of cancer cluster investigations
Small samples
Forced case definitions
Unclear geographic boundary
Migration
Long latency period
Poor exposure data- Poorly characterized, heterogeneous, low in concentration
Recall bias
List 3 functions of the Canadian Environmental Protection Act
Describe the difference between bioaccumulation, biomagnification, and biotransformation
Bioaccumulation: the progressive increase in amount of a chemical in an organ or organism as the rate of uptake exceeds the rate of excretion
Biomagnification: the sequence of processes in an ecosystem by which higher concentrations of a chemical are attained in organisms at higher levels of the food chain
Biotransformation: intermediary metabolism; biochemical changes that occur when a chemical reaches human cells to decrease (detox) or increase (activation) toxicity
What is the difference between the reference dose and tolerable daily intake (TDI) for a substance?
Tolerable Daily Intake (TDI): the estimate of total daily exposure that is unlikely to result in adverse health effect in a lifetime to a human population, usually expressed as mg/kg/day
Reference dose (RfD): estimate of total daily exposure that is likely to be without appreciable risk over a defined period of time, usually a lifetime. This term has replaced TDI and ADI (acceptable daily intake)
Define the precautionary principle
A small rural community has raised concerns that a nearby smelter is releasing large amounts of heavy metals into the air.
List and describe 4 steps of a risk assessment.
- Hazard identification: identify the agent, health effects, population impacted, and identify possible data sources
- Dose response - determine the LOEL and risk threshold (zero, de minimis, de manifestos, ALARA etc.)
- Exposure assessment - estimate exposures along the source to human pathway (soil/water/air, location, population, route of exposure (dermal, ingestion, inhalation), magnitude, duration)
- Risk characterisation - summary of the risk (quantitative or qualitative), make sure to acknowledge assumptions
Provide 6 examples of mitigation measures against an environmental hazard using the agent-path-receptor framework
- Remove the hazard
- Remediation
- Containment
- Block transmission
- Relocate people
- Change the land use
List 5 IARC group 1 heavy metals and the cancers they cause
- Arsenic - lung, skin
- Cadmium - lung
- Aluminum - bladder
- Iodine - thyroid
- Nickle - nasal cavity
List 5 outrage factors and 5 safe factors to consider when communicating risk
General principles: be first, be credible, be right.
Outrage factors: MUSIC
- morally relevant, memorable
- unfair
- scary or dreaded
- industrial hazard (vs. natural)
- catastrophic (vs. chronic)
Safe factors: VICTOR
- voluntary
- control
- trusted source
- old threat vs new
- responsive
Where do heavy metals come from and why are they an issue of public health importance?
Typically released from natural sources (the Earth’s crust) or industrial sources (mining, smelting0
Issue of public health importance because they can be toxic at low doses and tend to persist for long periods without degrading
What is the MAC and blood limit for for lead?
MAC 0.005mg/L
BLL 10 micrograms/dL
What is the MAC and blood limit for mercury?
MAC 1 microgram/L
Blood mercury limit 5.8 microgram/L
What is the recommended limit for fish consumption to avoid mercury toxicity?
150g/week for the general population
150g/ month for pregnant people
125g/month for children 5-11
<75g/month for children 1-4
List 2 acute and 2 chronic health effects from lead
Acute: nausea/vomiting, abdominal pain, drowsiness, encephalopathy, death
Chronic: developmental delay, motor deficits, anemia, hypertension, miscarriage
List 2 acute and 2 chronic health effects from mercury
Acute: parenthesis, dysarthria, weakness, minimata disease, AKI
Chronic: acrodynia, Mad Hatter disease, developmental delay
List 2 acute and 2 chronic health effects from arsenic
Acute: cardiotixicity, encephalopathy, cramping, nausea/vomiting/diarrhea
Chronic: neurotoxicity, peripheral neuropathy, bone marrow suppression, diabetes mellitus, bladder cancer, lung cancer, SCC
List 2 acute and 2 chronic health effects of cadmium
Acute: headache, weakness, pneumonitis, Itai-Itai disease
Chronic: COPD, nephrotoxicity, lung cancer
What are endocrine disruptors and why are they of public health importance?
Endocrine disruptors are a group of synthetic chemicals that impact the synthesis, transportation, binding, or metabolism of endogenous human hormones.
They are of public health importance because they can lead to growth failure/short stature, developmental disabilities, impaired sexual development, infertility, increase susceptibility to cancer, and disruptions in the immune and nervous systems
List 2 routes through which people could be exposed to BPA and 2 risk mitigation measures.
Routes: ingestion, inhalation (usually from polycarbonate plastics in food containers)
Mitigation measures: ban products with BPA, check the components in food containers, microwave food in glass only
Additional info:
BPA is categorised as an endocrine disruptor and can lead to fertility with a possible role in obesity and metabolic disease
List 2 routes through which people could be exposed to phthalates and 2 risk mitigation measures
Routes: Ingestion (water), inhalation
Mitigation measures: choose phthalate-free personal care products, wear a mask if working with construction materials that could contain phthalates
Additional info:
Phthalates are a group of endocrine disruptors that are found in plastics such as PVC and construction materials as well as personal care products like perfume, hair gel, and lotion. Most phthalates have no known health effects but DEHP is IARC 2B for HCC and adenomas. There is a possible link between phthalates and disruptions in the reproductive system
What are volatile organic compounds and why are they a threat to health?
VOC’s are chemicals that easily evaporate (volatile); precursors to ground level ozone, from natural and anthropogenic sources such as forest fires, animals, cigarettes, crude oil, coal, industrial solvents, and dry cleaning products.
Health effects include drowsiness/ altered level of consciousness, anemia, neurotoxicity, hepatotoxicity, skin irritation, leukemia, and renal cancer
List 2 sources of benzene, the usual route of exposure, and 2 examples of risk mitigation measures.
Sources: crude oil seepage, incomplete combustion of organic materials, coal, industrial solvents, gasoline evaporation, industrial intermediates (plastics, acetone, rubber, detergents, dyes)
Route of exposure: inhalation
Mitigation: Avoid indoor gas heating, don’t store benzene-containing products inside the home, no smoking inside
Note: IARC Group 1 for AML
List 2 sources of trichloroethylene, the usual route of exposure, and 2 examples of risk mitigation measures.
Sources: Pain remover, grease remover, dry cleaning products
Exposure: inhalation, ingestion in water or food
Mitigation: Regulation of the use and disposal of trichloroethylene-containing products, stop manufacturing trichloroethylene-containing products in Canada
Note: IARC Group 1 for renal cancer
What are Persistent Organic Pollutants (POP’s) and what are their health impacts?
POP’s are synthetic substances from industrial production that last int he same environment for a long time. They can biomagnify in the food chain. Health effects include disruptions in the immune system, nervous system, and endocrine system.
List 2 health effects of polychlorinated biphenyls, 2 common sources, and 2 mitigation measures
Health effects: skin discolouration, hepatotoxicity, disruption in immune system, endocrine, and nervous systems
Sources: electrical capacitors/transformers, flame retardant, adhesives, lubricants, plasticisers.
Mitigation: Regulation to restrict the use in Canada (the Stockholm Convention global treaty to decrease or eliminate use), avoid burning treated/painted wood
Note: route of exposure is usually ingestion through contaminated water or food. Accumulates in fatty tissues in animals e.g. fish
List 2 sources of dioxins or furans, and 2 mitigation measures
Sources: iron and steel production, wood burning, burning solid and liquid fuels, smoking
Mitigation: Avoid burning garbage, avoid burning treated wood or plastic, trim the fat before eating meat or fish
Note: route of exposure is usually ingestion from milk, meat, or fish living in contaminated environments, inhalation from cigarettes are another route/source.
TCDD is IARC Group1 for all sites combined