Enzymes to Know

Question 1

What is p450scc aka
2 alpha hydroxylase aka
cholesterol desmolase?

Answer 1

Converts Cholesterol to Pregnenolone
Often a rate limiting step
Activated by ACTH

Question 2

What is 3 beta hydroxysteroid dehydrogenase?

Answer 2

Pregnenolone to Progesterone
17-hydroxyprenelone to 17 hydroxyprogesterone
Dehydroepiandrosterone to Androstenendione
Androstendiol to Testosterone

Question 3

What is 21 Beta Hydroxylase aka

CYP21A?

Answer 3

Progesterone to Deoxycorticosterone (DOC)
17 hydroxyprogesterone to deoxycortisol
the most common deficiency in CAH

Question 4

What is 11 Beta Hydroxylase aka

CYP11B1?

Answer 4

DOC to Corticosterone

Deoxycortisol to Cortisol

Question 5

What is 18 hydroxysteroid aka
Aldosterone Synthase aka
CYP11B2?

Answer 5

Corticosterone to Aldosterone

RAAS activates?

Question 6

What is 17 alpha hydroxylase?

Answer 6

Pregnenolone to 17 hydroxypregnenolone

Progesterone to 17 hydroxyprogesterone

Question 7

What is 17, 20 Lyase?

Answer 7

17 hydroxypregnenolone to dehydroepiandrosterone

17 hydroxyprogesterone to androstenedione

Question 8

What is 11 BHSD2?

What is 11 BHSD1?

Answer 8

2) Cortisol to Cortisone

1) Cortisone to Cortisol