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MEDSCI 313 > Enzymes for steroidogenesis > Flashcards

Enzymes for steroidogenesis Flashcards

1
Q

Converts cholesterol to pregnenolone.

A

Cholesterol Desmolase

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2
Q

Another name for cholesterol desmolase.

A

CYP11A

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3
Q

What hormone is the rate limiting step of cholesterol to pregnenolone?

A

LH

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4
Q

What does 3B-hydroxysteroid dehydrogenase do?

A

Converts pregnenolone to progesterone

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5
Q

What converts pregnenolone to progesterone?

A

3B-hydroxysteroid dehydrogenase

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6
Q

What are the substrates in the steps of producing testosterone?

A 
Cholesterol
Pregnenolone
17-OH Pregnenolone
Dehydroepi-androsterone
Androstenedione
Testosterone
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7
Q

What enzyme converts pregnenolone to 17-OH pregnenolone?

A

17a - hydroxylase

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8
Q

17-OH Pregnenolone -> dehydroepi-androsterone

A

17,20 Lyase

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9
Q

Dehydroepi-androsterone -> androstenedione

A

3B - hydroxysteroid dehydrogenase

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10
Q

Androstenedione -> Testosterone

A

17B - hydroxysteroid dehydrogenase

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11
Q

What are the substrates in the steps of producing oestradiol?

A 
Cholesterol
Pregnenalone
17-OH pregnenalone
Dehydroepi-androsterone
Androstenedione
 -> Testosterone -> Estradiol
 -> Estrone -> Estradiol
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12
Q

Testosterone -> Estradiol

A

Aromatase

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13
Q

Androstenedione -> Estrone

A

Aromatase

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14
Q

Estrone -> estradiol

A

17B - hydroxysteroid dehydrogenase

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15
Q

What enzyme produces 5a-DHT from androgens?

A

5a-reductase

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16
Q

What two androgens can produce 5a-DHT?

A

Testosterone and androstenedione

MEDSCI 313 (3 decks)

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