Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PK > Enzymes and stuffs for Exam 2 > Flashcards

Enzymes and stuffs for Exam 2 Flashcards

1
Q

EFV/NVP + rifampin pk result

A

Decreased [EFV/NVP]

Increase dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

EFV/NVP + statins pk result

A

Decreased [statins]

Monitor cholesterol/more aggressive statin dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

RPV + PPIs pk results

A

Decreased [RPV]

Avoid this combo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ETV + PIs pk result

A

Decreased [PI]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ETV + warfarin pk result

A

Increased [warfarin]

Monitor INR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Contraindicated with PIs

A 
Rifampin
St. John's Wort
Pimozide
Lovastatin/simvastatin
Triazolam/midazolam
Ergots
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PI + rifampin pk results

A

Decreased PI

Increased RIF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

PI + St. John’s Wort

A

Decreased PI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PI + triazolam/midazolam

A

Increased triazolam/midazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PI + pimozide

A

Increased pimozide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PI + ergots

A

Increased ergots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PI + lovastatin/simvastatin

A

Increased Lovastatin/simvastatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ATV + PPIs

A

Decreased ATV
Avoid use in experience pts w/ resistance
Always boost with RTV
Max omeprazole 20mg/d or equivalent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PIs + amiodarone, lidocaine, quinide, bepridil

A

Increased anti-arrhythmics

Avoid if possible; TDM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

PIs + trazodone

A

Increased trazodone

Use lowest dose possible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

PIs + immunosuppressants

A

Increased immunosuppressants

TDM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

PIs + statins

A

Increased statins

Prava/atorv preferred (+/- rosuv)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

PIs + fluticasone

A

Increased fluticasone

Use alternative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

MVC + inhibitor

A

Increased MVC

Halve MVC dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

MVC + inducer

A

Decreased MVC

Double MVC dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

RAL + rifampin

A

Decreased RAL

Double RAL dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

RAL + phenytoin/phenobarbital

A

Potentially decreased RAL

Use caution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

EVG

A

Coformulated with cobi - follow cobi guide

Similar to ritonavir - similar interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

DTG + dofetilide

A

Increased dofetilide

Contraindicated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

DTG + rifampin

A

Decreased DTG

Increase DTG dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

DTG + cations

A

Take DTG 2 hours before/6 hours after cations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Cobi contraindications

A 
Rifampin
St. John's Wort
Sildenafil
ergot
lovastatin/simvastatin
triazolam/midazolam
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

SOF

A

NS5B nucleotide polymerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

LDV

A

NS5A inhibitor

30
Q

Absorption of Harvoni

A

Tmax = 4 hours

31
Q

Distribution of SOF

A

65%

32
Q

Distribution of LDV

A

> 99%

33
Q

Metabolism of SOF

A

Hydrolysis and phosphorylation/dephosphorylation to an active metabolite

34
Q

Elimination of SOF

A

Renal (80%)

35
Q

Elimination of LDV

A

Biliary/feces

36
Q

Metabolism of LDV

A

Via oxidative metabolism

37
Q

Half-life of SOF

A

25

38
Q

Half-life of LDV

A

47

39
Q

Absorption of Epclusa

A

Tmax: 3 hours

40
Q

Distribution of VEL

A

> 99%

41
Q

Metabolism of VEL

A

2B6
2C8
3A4

42
Q

Elimination of VEL

A

Biliary/feces

43
Q

Half-life of VEL

A

15 hours

44
Q

Ombitasvir

A

NS5A inhibitor

45
Q

Paritapravir

A

NS3/4A protease inhibitor

46
Q

Dasabuvir

A

NS5B non-nucleoside polymerase inhibitor

47
Q

Absorption of Viekira XR

A

Tmax = 4-8 hours

Food enhances absorption

48
Q

Distribution of Viekira XR

A

> 97%

High apparent Vd for all 4 components

49
Q

Ombitasvir metabolism

A

Amide hydrolysis, followed by oxidative metabolism

50
Q

Paritaprevir metabolism

A

3A4

51
Q

Ritonavir metabolism

A

Mostly 3A4

To lesser extent by 2D6

52
Q

Dasabuvir metabolism

A

Mostly 2C8

To lesser extent 3A4

53
Q

Elimination of Viekira XR

A

Predominantly feces

Minimal renal elimination

54
Q

Ombitasvir half-life

A

21-25 hours

55
Q

Paritaprevir half-life

A

5.5 hours

56
Q

Ritonavir half-life

A

4 hours

57
Q

Dasabuvir half-life

A

5.5-6.0

58
Q

Elbasvir

A

NS5A inhibitor

59
Q

Grazoprevir

A

NS3/4A protease inhibitor

60
Q

Elbasvir absorption

A

Tmax: 3-6 hours

61
Q

Grazoprevir absorption

A

Tmax: 0.5-3 hours

62
Q

Zepatier distribution

A

> 97%

High Vd

63
Q

Zepatier metabolism

A

3A

- only drug approved for patients with all CrCl

64
Q

Zepatier elimination

A

Predominantly via feces

Minimal renal elimination

65
Q

Elbasvir half-life

A

24 hours

66
Q

Grazoprevir half-life

A

31 hours

67
Q

Ritonavir and CYP

A

inhibitor of 3A4

68
Q

Contraindications with Viekira XR

A

Anticonvulsants: carbamazepine, phenytoin, phenobarbital
Antimycobacterial: rifampin
Herbal: St. John’s Wort
Statins: lovastatin/simvastatin

69
Q

Contraindications with Zepatier

A

Anticonvulsants: phenytoin, carbamazepine
Antimycobacterial: rifampin
Herbal: St. John’s Wort
Immunosuppressants: CsA

70
Q

Drugs not recommended with Harvoni/Epclusa

A

Amiodarone
P-gp inducers: rifampin, St. John’s wort
Anticonvulsants

71
Q

Drugs not recommended with Zepatier

A

3A4 inducers: nafcillin

3A4 inhibitors: ketoconazole, cobi

PK (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions