Enzymes

Question 1

Streptokinase can be used for what kind of treatment?

Answer 1

stroke and heart attack
- dissolve insoluble fibrin

Question 2

Asparaginase can be used for what kind of treatment?

Answer 2

some paediatric leukemias
- remove asparagine (nutrients for the cancer) from the cancer

Question 3

Rifampicin makes oral contraceptives inactive. T or F.

Answer 3

T cuz it induces the CYP3A4 needed for COC metabolism

Question 4

Grapefruit juice while on warfarin can cause excessive bleeding. T or F.

Answer 4

T cuz it inhibits the CYP3A4 needed for warfarin metabolism (toxic levels of warfarin)

Question 5

Give 2 egs of protease inhibitors.

Answer 5

• captopril: inhibits angiotension-converting enzyme; used for hypertension
• retrovir: inhibits HIV protease; used for HIV

Question 6

Give 4 egs of enzyme deficiency diseases.

Answer 6

• Tay-sachs disease: beta-hexosaminidase A; build up of GM2 ganglioside
• Phenylketonuria: phenylalanine hydroxylase; build up of phenylalanine
• Lesch-nyhan syndrome: hypoxanthine-guanine phosphoribosyltransferase; build up of uric acid
• Hereditary orotic aciduria: uridine monophosphate synthase; build up of orotic acid