Enzyme Linked Receptors (RTKs)

Question 1

Basic mechanism of RTKs

Answer 1

Receptors dimerise upon ligand binding.
Autophosphorylation of tyrosine molecules is seen.
Proteins bind via their SH2 domains to the phosphorylated tyrosine.
Allows a protein complex to form which then conveys cellular signals.

Question 2

Example RTK

Answer 2

Insulin receptor (via IRS)