enzyme inhibitors

Question 1

explain a competitive inhibitor

Answer 1

-molecules of similar shape to a substrate which competes with substrate blocking the active site so no ESC can be formed
-most are reversible
-reduce its effect by increasing the substrate concentration
-maximum rate of reaction can be reached
-doesn’t affect tertiary structure

Question 2

draw a graph for a competitive inhibitor

Question 3

explain a non-competitive inhibitor

Answer 3

-molecule which binds to enzymes allosteric site= active site changes shape = substrate can’t fit= reduces rate of reaction
-affects tertiary structure of enzyme
-most are irreversible
-increasing substrate concentration has no effect
-maximum rate can’t be reached

Question 4

draw a graph for a non-competitive inhibitor

Question 5

explain end product inhibition and what the advantage of it is to the cell

Answer 5

-the end product of a metabolic pathway (sequence of enzyme controlled reactions) inhibits the first enzyme in the pathway by binding to its allosteric site

-prevents too many wasteful products to be made in cell

Question 6

what is negative feedback

Answer 6

-mechanism that reverses the change and brings conditions back to normal